Sentences with phrase «in other cell lines»

To determine whether the reactivation of methylation - silenced genes by EGCG is a general phenomenon that also occurs in other cell lines, we studied the effects of EGCG treatment on the methylation status and mRNA levels of p16INK4a or RARβ in three other human cancer cell lines (Fig. 3C) ⇓.

It should be emphasized, however, that only after 2009 was XMRV known to be present in 22Rv1 cells or in any other cell line [35].

Not exact matches

The bottom line and then I'll shut up: in a healthy conversation, with no one trying to WIN THE ARGUMENT, this cartoon should be both cell colors freely mixing with each other — not «converting» or merging with one another.

Modern psychosomatic medicine has made some progress in analyzing along these lines; for example, it seems quite possible that the emotional tone of my soul may directly alter the patterns of physical feeling in my stomach.4 Still, we should not suppose too quickly that the aims of a human personality have any very effective direct influence on the molecules of body cells, other than those in the brain.

Also, the NCM460 cell line that Dr. Ebert and the carrageenan lobby criticize is derived from normal colonic mucosa and is useful to model effects on colonic cells, in the same way that other intestinal cell lines, such as Caco2 and HT29, are useful.

But when I asked this question yesterday at our Food Services Parent Advisory Committee meeting, I learned that not only does stigma remain a real issue at some schools, there's now a troubling, modern - day twist on the problem: on some campuses, hapless kids standing in the federally reimbursable meal line are having their pictures taken by other students» cell phones, with the photos then uploaded to Facebook and / or texted around the school along with disparaging messages about the child's economic status.

Endometriosis occurs in women when cells from the lining of the womb grown in other areas of the body.

That is because such a storm acts like a train, with individual storm cells rapidly reforming behind each other in a line, following a narrow path as if on rails.

The scientists also generated a panel of (reconstructed) ancestral and existing TRIM5 genes (19 total), expressed them in cultured cell lines, and exposed the cells to 16 different retroviruses (lentiviruses and others) to see which TRIM5 versions conferred resistance to which viruses.

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

The unaltered hemagglutinin is akin to a key that unlocks a so - called receptor molecule in cells lining the upper airways of humans and other mammals.

As other researchers asked for samples, the cells replicated, grew, and proliferated so wildly that they often took over and wiped out cell lines of any kind with which they happened to come in contact.

In 2012, Korch, Masters and 16 other scientists formed the International Cell Line Authentication Committee (ICLAC).

The researchers also want to see what other proteins and mRNAs are involved in the relationship, and why some cancer cell lines they tested did not show the same increased ALKBH5 levels in response to low oxygen levels.

On the other hand, the problem is, you know, with embryonic stem cells, they haven't been able to get stem cell lines from livestock animals that can proliferate in that way, without just sort of veering up in their own direction and turning into, instead of muscle, turning into brain tissue or bone tissue or something else.

According to Bolton, 8 - PN showed only a slight increase of metabolism in breast cells, while the other two compounds did not have significant effects in either cell line.

However, these poisons can also do significant harm to other dividing cells such as those found in the stomach lining and in hair and nail follicles, as well as the blood and immune stem cells in the bone marrow.

In one study, geneticist Joseph Ecker at the Salk Institute in California took various stem cell lines reprogrammed from skin, fat, and other tissues and examined each line's genome for dna methylation, chemical marks that alter how genes are expresseIn one study, geneticist Joseph Ecker at the Salk Institute in California took various stem cell lines reprogrammed from skin, fat, and other tissues and examined each line's genome for dna methylation, chemical marks that alter how genes are expressein California took various stem cell lines reprogrammed from skin, fat, and other tissues and examined each line's genome for dna methylation, chemical marks that alter how genes are expressed.

In experiments with cancer cell lines, the PIM1 inhibitors killed cells in a MYC - dependent manner, and in two different mouse models — one in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regressioIn experiments with cancer cell lines, the PIM1 inhibitors killed cells in a MYC - dependent manner, and in two different mouse models — one in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regressioin a MYC - dependent manner, and in two different mouse models — one in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regressioin two different mouse models — one in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regressioin which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regressioin which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regressioin significant tumor regression.

«The lining comprises one cell type unlike any in other species we have seen,» says Power.

Where the second type of condensin, which is present in humans and other multicellular organisms, binds during cell division is another future line of inquiry.

The toxicity of chokeberry extract on normal blood vessel lining cells was tested and found to have no effects up to the highest levels used (50 ug / ml), suggesting that the cell death effect is happening in a way other than through preventing new blood vessel formation (anti-angiogenesis), a process that is important in cancer cell growth.

In other organisms, there is instead a signaling mechanism: An embryonic cell receives chemical signals from neighboring cells that activate (or repress) the genes that allow for germ - line function.

In other words, APOBEC3A preempts a potential mutation by LINE - 1 jumping, by itself causing a mutation in the new LINE - 1 copy that the cell then destroyIn other words, APOBEC3A preempts a potential mutation by LINE - 1 jumping, by itself causing a mutation in the new LINE - 1 copy that the cell then destroyin the new LINE - 1 copy that the cell then destroys.

«Further tests conducted at the Institute for Molecular Bioscience demonstrated that this compound was more toxic to cancer cell lines than other compounds found in sea slugs.»

When Sukumar and the others depleted the HOXA5 protein in other breast cell lines in the lab, the cells became more immature, or «stem like,» as well as more mobile.

In contrast to other cultured cells, such tumor cells can divide indefinitely and a cell line can therefore be cultured for many years.

There are two - dimensional polymer - like assemblies that occur naturally, such as in cell membranes, where large molecules line up parallel to each other and are held together in a layer by electrostatic attraction.

Among other effects, immune cells disrupt the function of the endothelial layer, the lining of the blood vessels, counteracting «all the good things that the endothelial cells produce,» says physiologist Brett Mitchell of Texas A&M College of Medicine in College Station.

What Carraher and Seigmann - Louda found — but are as yet unable to explain — was that their drug - polymer mix dramatically inhibited the growth of both lines; in one, cell division was stalled by 97 percent and in the other, 80 percent.

The possibility of such cells has been debated at least since the 1950s, when researchers found single neurons in the visual cortex of cats and other animals that respond to simple stimuli, such as lines oriented at a certain angle or moving in a specific direction, or light of a particular wavelength.

When the team split this cell line into different dishes, sometimes the donor egg's mtDNA won out; but in others, the carried - over mtDNA dominated.

In other cases, the goal was to establish a line of embryonic stem cells.

In line with other known cases of Bt - resistance, resistance in Busseola fusca was expected to involve modification of the cells in the gut wall, which prevents the toxin from bindinIn line with other known cases of Bt - resistance, resistance in Busseola fusca was expected to involve modification of the cells in the gut wall, which prevents the toxin from bindinin Busseola fusca was expected to involve modification of the cells in the gut wall, which prevents the toxin from bindinin the gut wall, which prevents the toxin from binding.

One of the studies, by Johns Hopkins University scientists in collaboration with many other groups, turned up unexpected hints that biochemical signals controlling blood pressure may spring from within cells that line blood vessels themselves.

Scientists typically don't classify viruses as living organisms, but giant viruses like these, with their own protein - making machinery and other functions normally carried out in living cells, blur the lines between what's alive and what isn't.

As a result, cell phone makers do not offer many models that have adequate processing power to run video smoothly, and digital cameras in U.S. cell phones are on the opposite side from the display screen (which would make it impossible to see the person on the other end of the line while exchanging sign language).

«In the future we are hopeful that BH3 - mimetics may be a valuable new line of treatment for Legionella and other bacteria that similarly hide out within cells,» Dr Vince said.

These findings are in line with other recent reports suggesting that group B coxsackieviruses can spread to the pancreas and damage the insulin - producing cells.

In other studies, however, using cell lines either in vivo or in vitro suggest that the alpha2 beta1 integrin may serve to enhance metastasis to different organIn other studies, however, using cell lines either in vivo or in vitro suggest that the alpha2 beta1 integrin may serve to enhance metastasis to different organin vivo or in vitro suggest that the alpha2 beta1 integrin may serve to enhance metastasis to different organin vitro suggest that the alpha2 beta1 integrin may serve to enhance metastasis to different organs.

The example shown reveals that these estrogen agonists show the strongest connectivity to each other in MCF7, a human breast cancer cell line that expresses the estrogen receptor.

In analyses of the cell lines, precursor white fat cells from two subjects responded strongly to BMP7 but such cells from the other two subjects did not.

Light red or light blue regions indicate positive or negative outlier expression, respectively, of the gene relative to the other lines shown; z - score of a positive outlier in the corresponding cell line is in dark red and a negative outlier is in dark blue.

He added: «Truly naive human ES cell lines would not only help answer fundamental questions about how we are made, and be useful for drug screening and tissue therapy, but they would also provide a benchmark against which other types of stem cells could be measured in terms of their effectiveness in stem cell therapy and regenerative medicine.»

\ n \ nIn other words this is a political attempt, based on a technicality, to advance science in the field by getting the US Administration to greatly expand the number of human ES - cell lines that can be used under federal funding.

In the next decade, molecular research is going to further develop along five lines: predictive medicine, that investigates the genetic conditions predisposing to tumor risk; early molecular diagnosis; the evaluation of each patient's prognosis based on his / her genetic profile, in other words, the analysis of what kind of mutation affects the DNA of altered cells; the investigation of the individual response to drugs, based on our genetic knowledge; «smart drugs», molecules able to hit the target in a selective way, killing only the deprogrammed cells.&raquIn the next decade, molecular research is going to further develop along five lines: predictive medicine, that investigates the genetic conditions predisposing to tumor risk; early molecular diagnosis; the evaluation of each patient's prognosis based on his / her genetic profile, in other words, the analysis of what kind of mutation affects the DNA of altered cells; the investigation of the individual response to drugs, based on our genetic knowledge; «smart drugs», molecules able to hit the target in a selective way, killing only the deprogrammed cells.&raquin other words, the analysis of what kind of mutation affects the DNA of altered cells; the investigation of the individual response to drugs, based on our genetic knowledge; «smart drugs», molecules able to hit the target in a selective way, killing only the deprogrammed cells.&raquin a selective way, killing only the deprogrammed cells.»

The use of higher resolution techniques, such as array CGH and, soon, whole genome sequencing, will enhance the ability of researchers to examine stem cell lines to determine which are best — least likely to result in diseases and other problems — to use in creating therapies for use in humans.

The other 54 %, however, were hypomethylated in the cancer cell line.

The majority of gene - targeting experiments in mice are performed in 129Sv - derived embryonic stem (ES) cell lines, which are generally considered to be more reliable at colonizing the germ line than ES cells derived from other strains.

Registration of cell lines in hPSCreg will provide visibility, confidence in ethical provenance, validation of characterization data and comparability with other registered lines.