«We ought to suspend judgement on the test until it has been
replicated in other labs using very careful controls,» he says.
Q: Coming back to alternative careers, what advice would you give to young
scientists in other labs who want to start exploring their options?
Before MolProbity, validation tools
developed in other labs, such as PROCHECK, first available in 1993, and WHATCHECK, developed in 1997, provided statistical evaluations of solutions, applying Ramachandran and rotamer distributions, for example, to flag problem areas.
Even Andrew Jukes, who conducted the pepper tests at Warwick on which Guinness based the Naga Viper and Infinity records, concurs: «I am surprised that all record values are not verified on additional
samples in other labs.
Soon after arriving there last fall, Muller started working in Richardson's group while doing
rotations in other labs.
«An investment of only # 1 million a year could accommodate the expertise that is already in place and generate more
interest in other labs,» says Gale.
Xie points out that
studies in other labs have revealed that Bam also suppresses the expression of the protein Nanos.
A large, thorough hunt for a mouse retrovirus known as XMRV in people who have chronic fatigue syndrome (CFS)-- including in patients who tested positive for the
virus in other labs — has come up empty - handed, further deflating the hope that a cause for this baffling disease has been found.
One virus he selected for his experiments, known as an adeno - associated virus, proved to be promising in human gene - therapy
trials in other labs.
The finding, published in the current issue of Genes and Development1 represents a different approach to cultivating specialized cells for transplant therapy than that being
pursued in other labs.
While it is exciting, the full potential of this research will be unknown until the results can be
duplicated in other labs and replicated with older tissues and within other species, including humans.
While
investigators in other labs have suggested that raised rather than lower levels of cholesterol may be linked to brain disorders, «we think our model may be more clinically relevant,» she says.
The researchers plan to continue improving the technique, which will also benefit from future
work in other labs, and monitoring Zhong Zhong and Hua Hua for their physical and intellectual development.
The team has made all the information needed to create this system freely available, so that plant
scientists in other labs can use ACME in their own research.
Her lab is also working on adding features to the ROSETTA and ERRASER programs, both
developed in other labs, to allow ERRASER to do RNA structure corrections.
In other labs, researchers harnessed the technique to create a growing menagerie of genetically engineered animals and plants: extramuscular beagles, pigs resistant to several viruses, and wheat that can fend off a widespread fungus.
In other labs, some intriguing differences between male and female mice test subjects have already begun to emerge.
«There were more women in her lab than
in other labs,» says Casper.
Some scientists say these early findings from the Reproducibility Project: Cancer Biology, which appear tomorrow in eLife, bolster concerns that too many basic biomedical studies don't hold up
in other labs.