Sentences with phrase «in outer segment»

The RPE serves a critical role in outer segment (OS) renewal.

Mfrprd6 mice demonstrate abnormal RPE microvilli development, a delay in outer segment development, an impaired ability to phagocytize shed OSs, and potentially, an impairment of adhesion between RPE and outer segments.

Reduction of all - trans retinal to all - trans retinol in the outer segments of frog and mouse rod photoreceptors.

Microfluorometric Measurement of the Formation of All - Trans - Retinol in the Outer Segments of Single Isolated Vertebrate Photoreceptors.

Conservation of visual acuity in the iPS - RPE transplanted eyes was associated with the preservation of photoreceptors in the host outer nuclear layer (ONL — Fig. 7A), identified by the expression of rhodopsin in the outer segments of photoreceptors (Fig. 7A inset, Dystrophic + transplant).

Not exact matches

The rod outer segment is made up of stacked discs each containing many types of proteins, in particular rhodopsin, a light - sensitive pigment.

Optical Coherence Tomography (OCT) imaging revealed the loss of outer segments in foveal cone cells in the «optical gap» of a patient with ATF6A defects.

The active cryptochrome 1 is found in the light - sensitive outer segments of the cone cells.

In wild - type, retinal ganglion cell layer (GCL), inner nuclear layer (INL), inner plexiform layer (IPL), and nuclear layers of rod and cone photoreceptors are distinct, and rod outer segment (OS) is observed at the outer-most layer of the retina.

Oil droplets, outer, and inner segments were observed in cells expressing photoreceptor specific markers (Figure 7B and 7C).

Rapid formation of all - trans retinol after bleaching in frog and mouse rod photoreceptor outer segments.

In this well - studied model of autosomal recessive retinitis pigmentosa and secondary photoreceptor degeneration, a MERTK mutation in the RPE compromises their ability to phagocytose shed photoreceptor outer segments [35]--[37In this well - studied model of autosomal recessive retinitis pigmentosa and secondary photoreceptor degeneration, a MERTK mutation in the RPE compromises their ability to phagocytose shed photoreceptor outer segments [35]--[37in the RPE compromises their ability to phagocytose shed photoreceptor outer segments [35]--[37].

The progression of retinal dystrophy in the RCS rat is such that by 13 weeks post-graft most of the ONL has disappeared [33] and the photoreceptor outer segment layer is reduced to a debris zone [40], a finding we observed in dystrophic controls.

iPS - RPE were able to phagocytose fluorescently labelled porcine photoreceptor outer segments (POS) in co-culture.

(E) Rhodopsin - positive material (red) is present within the cell membrane of human specific marker (HSM)- labelled iPS - RPE (green) 8 days post-transplantation and in the tips of the host outer segment (OS) layer.

(A) Confocal images showing phagocytosis of isolated FITC - labelled porcine photoreceptor outer segments (POS — green) by iPS - RPE in culture.

Labelled outer segments were washed, resuspended in human foetal RPE medium and seeded onto iPS - RPE cells cultured on gelatin - coated 35 mm dishes.

Phagocytosis of fluorescently labelled photoreceptor outer segments (green) by iPS - RPE cells in vitro.

Importantly, akin to HESC - RPE in vivo, cells at the outside edge of the iPS - RPE cell bolus could phagocytose photoreceptor outer segments from the RCS rat, as indicated by the presence of rhodopsin - positive photoreceptor material within the cellular membrane of iPS - RPE labelled with HSM (Fig. 5E).

Immunocyctochemistry was also used to assess phagocytosis of host outer segments in vivo.

The director has done long scenes before — a seven - minute segment in «Children of Men» is especially memorable — but he's never pulled one off with all the built - in barriers of working in a facsimile of outer space.

Their outer segments are upholstered in black Nappa leather; anthracite - coloured Nappa leather («Light Anthracite») is used towards the inner surfaces in the area of the lateral seat supports and towards the head section.

The gene product's precise role is not currently understood but it is thought to anchor regulatory complexes at the photoreceptor connecting cilium, which acts as a bridge between the inner and outer segments of photoreceptor cells [43] as well as having functions in disk morphogenesis [42] and in the structure of the ciliary axoneme [44].

Previous studies have shown the requirement of CNGB1 for normal targeting of CNGA1 to the rod outer segment [16] and indeed the authors were able to demonstrate a lack of detectable CNGA1 protein in the rod outer segments of the affected Papillons homozygous for the mutation [15].

In RCD3 affected dogs normal rod - mediated ERG responses fail to develop, photoreceptor outer segments do not reach maturity and rod cells are lost by apoptosis [5].

The stadium - wave «wheel» is divided into segments (from center to perimeter): the light gray ring identifies the segment number; the dark gray ring indicates key hemispheric indices; sea ice indices are in the yellow ring; and the outer green ring provides peak dates for the segment.

Rather, they sit loosely in the outer ear with the inner segment locking behind the tragus.