Not exact matches
Mutations
in these genes have been associated with one of the deadliest types of
ovarian cancer, called clear cell
carcinoma.
For the new study, described
in the October 23rd issue of Nature Communications, scientists at the Johns Hopkins Kimmel Cancer Center and Dana Farber Cancer Institute
in Boston collected tissue samples containing normal cells,
ovarian cancers, metastases that had spread elsewhere, and small cancers found
in the fallopian tubes, which included single cell layers of cancer called «p53 signatures» and serous tubal intraepithelial
carcinoma, or STIC lesions.
In another set of experiments, the team implanted human
ovarian carcinoma cells into mice.
The class of compounds that includes GDC - 0449 could also help contain other cancers, such as
ovarian and colorectal cancers, that are not triggered
in the same way as medulloblastoma or basal cell
carcinoma but that are still partly driven by aberrant Hedgehog signaling.
Hodi FS, Mihm MC, Soiffer RJ, Haluska FG, Butler M, Seiden MV, Davis T, Henry - Spires R, MacRae S, Willman A, Padera R, Jaklitsch MT, Shankar S, Chen TC, Korman A, Allison JP, Dranoff G. Biologic activity of cytotoxic T lymphocyte - associated antigen 4 antibody blockade
in previously vaccinated metastatic melanoma and
ovarian carcinoma patients.
Major Discovery
in Ovarian Cancer Investigators linked mutations in two genes to ovarian clear cell carcinoma, one of the most aggressive and treatment - resistant forms of ovarian
Ovarian Cancer Investigators linked mutations
in two genes to
ovarian clear cell carcinoma, one of the most aggressive and treatment - resistant forms of ovarian
ovarian clear cell
carcinoma, one of the most aggressive and treatment - resistant forms of
ovarian ovarian cancer.
Most
ovarian cancers are serous
carcinomas, which develop
in the tissue lining the ovaries and are subtyped into high - grade and low - grade.
We demonstrated that the other MAP3K, MAP3K8, accumulates
in high - grade
ovarian carcinomas and is a new prognostic marker for these tumours.
ab51608 staining HIF -1-alpha
in Human
ovarian carcinoma tissue sections by Immunohistochemistry (IHC - P - paraformaldehyde - fixed, paraffin - embedded sections).
Women are generally
in this group if they have multiple cases of breast or
ovarian cancer
in the family, a positive result on the BRCA breast cancer gene - mutation test, a personal history of the disease, or a biopsy showing atypia or lobular
carcinoma in situ.
Thaker PH, Han LY, Kamat AA, et al: Chronic stress promotes tumor growth and angiogenesis
in a mouse model of
ovarian carcinoma.
Also, when the liver can not properly detoxify estrogen, the hormone goes back into the bloodstream
in a more toxic form, raising the risk for breast cancer, endometriosis, premenstrual syndrome, fibrocystic breasts,
ovarian cysts, cervical dysplasia, endometrial cancer, prostate
carcinoma and hyperplasia, and menopause.