Sentences with phrase «in particular cell types»

While the genetic code carried in our DNA provides instructions for cells to manufacture specific proteins, it is a second code that determines which genes are in fact activated in particular cell types.

These specialised processes involve proteins that are mainly expressed in this particular cell type throughout the body, which are often modulated in vascular disease.

By counting the number of enterocytes along the a / p axis, bands of GFP expression were approximately mapped to subregions (Figure 1F — G, dashed lines) in each particular cell type (Figure 1 — figure supplement 2).

Not exact matches

Embryonic cells are pluripotent, having the full genetic code enabling them to become any type of cell; they differentiate into particular cells in their later development.

«When someone has a problem — whether they need to find a particular cell line or need to understand the formulation of a particular type of culture medium — they're coming to you and they're in a crisis.

«The problem with plasma cell - free liquid biopsy in particular is that the amount of wild - type [DNA] can be very, very high, and so keeping that really rare signal from being swamped out by the wild - type... is key,» says Dawne Shelton, R&D manager for in vitro diagnostic products at Bio-Rad in Hercules, California.

«Each area of the brain is different with distinct cell types and connectivity, so if we can confirm that one area of circuitry is more involved in a particular symptom than another, we may eventually be able to treat a depression patient more efficiently than treating everyone the same way.»

In the presence of Acinetobacter and Akkermansia, they became a particular type of T helper cell, which trigger inflammation and help the immune system kill off invaders or infected cells, the researchers report today in the Proceedings of the National Academy of Sciences (PNASIn the presence of Acinetobacter and Akkermansia, they became a particular type of T helper cell, which trigger inflammation and help the immune system kill off invaders or infected cells, the researchers report today in the Proceedings of the National Academy of Sciences (PNASin the Proceedings of the National Academy of Sciences (PNAS).

Among patients who have this type of lung cancer, nearly one in three will carry a particular genetic mutation on their cancer cells.

The volunteers, ranging in age from 20 to 88, received injections under their retina of a particular type of eye cell, retinal pigment epithelium (RPE) cells, which were derived from hESCs in the lab.

Scientists are hopeful that ultimately these cells could be transformed in the laboratory to yield specific cell types needed for a particular treatment, or to cross the «blood - brain barrier» by expressing specific therapeutic agents that are released directly into the brain.

The company's goal is to create a comprehensive source of stem cells that could be of particular use for treating people of Middle Eastern descent, whose tissue types are often underrepresented in the public tissue banks such as those in the U.S. and elsewhere.

Living in overcrowded conditions appears to protect children and young adults against developing a particular type of Hodgkin lymphoma (HL), a cancer that originates from the lymphocytes (white blood cells).

New technologies are coming to the fore that allow interrogation of the types of cells interacting with tumors, in particular providing intelligence on the broad variety of complex associations between tumor cells and the immune system.

While studying why some mice resist HSK, a team led by immunologist Harvey Cantor of Harvard Medical School in Boston found that possession of a particular variant of one type of antibody renders T cells incapable of attacking tissue in the cornea, the transparent covering of the iris and pupil.

Knocking out a particular gene in muscle lets mice run twice as far as normal; knocking out the same gene in fat cells allows the animals to put on weight without developing type - 2 diabetes.

Too much of one particular type of fat, or lipid, in a membrane shifts and turns K - Ras, shoving its active portion away from the membrane and into the cell, where it can transmit cancer - causing signals.

Harvard School of Public Health (HSPH) researchers have discovered that a particular type of protein (hormone) found in fat cells helps regulate how glucose (blood sugar) is controlled and metabolized (used for energy) in the liver.

Dogs can do that because their noses contain 900 different types of olfactory receptors, chemical detectors in cells that respond to many different kinds of odor molecules in particular ways.

Cancer stem cells, a type of self - renewing cell found in tumors, are of particular interest because they are the main cell type responsible for tumor progression and for resistance to chemotherapy and radiotherapy, and therefore a major cause of tumor recurrence after treatment.

«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.

Yet in other cases, a missing cell type is responsible for causing a particular disease.

Understanding how a particular DNA sequence gives rise to a particular protein provides us with some insight into that protein, but a deeper investigation of how the protein is made, where it is located, and how much of it is present in different cell types is required to enable a true understanding of its function.

In lymph nodes, a particular type of stromal cells that forms a scaffold for lymphocytes to crawl around within the node normally secretes an enzyme called autotaxin, which is responsible for the production of the lipid signaling molecule, lysophosphatidic acid (LPA).

Previous studies have demonstrated that particular cell types, such as those that constitute the retina or cornea, can be created in the laboratory from pluripotent stem cells.

Agata Smogorzewska, head of the Laboratory of Genome Maintenance, wants to understand how cells repair interstrand cross-links, a particular type of DNA damage in which the two strands of the double helix that normally twine about each other become physically linked.

This research reveals a new type of cell fusion that is initiated to destroy a particular cell, and enlightens the evolution of sexual reproduction in flowering plants.

The screening revealed coibamide A to be capable of killing many types of cancer cells, but Ishmael decided to focus subsequent studies on two types in particular — brain tumors, or glioblastomas, and a breast cancer subtype known as triple negative breast cancer.

«To build tissues, we need to be able to take stem cells and use them to make many different cell types which are grouped together in particular spatial patterns,» explained Andres M. Bratt - Leal, the paper's first author and a former graduate student in McDevitt's lab.

In the present study, the researchers carried out a large - scale analysis of sympathetic nerve cells, from which they were able to demonstrate that there are many different types of sympathetic neurons and that the different types are associated with a particular functions.

These latter two cell types can mount effective immune responses to viruses and tumors; whereas, exhausted T cells fail and memory T cells, in particular, for long - lasting durable effects.

A particular type of macrophage known as microglia are found throughout the brain and spinal cord — in progressive forms of MS, they attack the CNS, causing chronic inflammation and damage to nerve cells.

They also found that the disruption of the connectivity of these cells during brain development causes alterations in brain oscillatory activity and disturbs the function of place cells, a type of pyramidal neuron that becomes active when an animal is located in a particular place in its environment.

Early in cerebellar development, particular cell types come to be distributed unevenly from top to bottom, creating a dorsal - ventral separation.

A particular type of stem cell found in muscle can give rise to new muscle tissue, so a team led by geneticist Luis Garcia of Généthon, a nonprofit biotechnology firm in Évry, France, investigated whether these cells could be used to reverse the dystrophin problems.

Their study in aged mice indicates that high folic acid intake causes lowered immune function because natural killer (NK) cells, a particular type of immune cell, are less effective.

The research provides more evidence for how these lncRNAs, which were once thought to be a type of «junk DNA» of no particular value or function, may instead play a critical role in triggering cells to become malignant and spread.

«We were interested in the origins of lamprey gut neurons because in other vertebrates they arise from a particular embryonic cell type, called neural crest cells,» says Stephen Green, postdoctoral scholar in biology and biological engineering and co-first author on the paper.

In research published this week in the Journal of Neuroscience, University at Buffalo scientists and colleagues focused on a particular protein, called a transcription factor, that regulates gene activity necessary for the development of one type of retinal neuron, the horizontal cellIn research published this week in the Journal of Neuroscience, University at Buffalo scientists and colleagues focused on a particular protein, called a transcription factor, that regulates gene activity necessary for the development of one type of retinal neuron, the horizontal cellin the Journal of Neuroscience, University at Buffalo scientists and colleagues focused on a particular protein, called a transcription factor, that regulates gene activity necessary for the development of one type of retinal neuron, the horizontal cells.

The findings suggested that different types of blood cells produce vastly different amounts of protein per hour, and stem cells in particular synthesize much less protein than any other blood - forming cells.

The researchers counted the numbers of a particular type of immune cell, known as microglia, in the samples and found that these were more numerous in the brains with Alzheimer's disease.

And next - generation sequencing, in particular, RNA sequencing, allows researchers to delineate changing patterns of gene expression as new cell types form.

Although both cell types come from cells known as myeloid progenitors, each type relies on its own set of functionally active genes to carry out its particular role in fighting infection.

The Hippocampal Formation contains several types of cells which code for different aspects of space: the animal's current location within the environment, its heading direction, the distance over which it travels in a particular direction, and the location of environmental boundaries.

The things that we have demonstrated — such as the fact that the vertical nanowires can deliver any biological effector to any cell type in a spatially selected fashion — have drawn interest from many different people, and we have been working with stem cell institutes and others to demonstrate the unique utility of this particular platform.

We need to modify brain activity in humans to test whether particular brain regions contribute to perception and behavior, and we need to do the same in animals to modify activity in particular cell - types to understand the molecular basis of these processes.

In particular, they are now looking for expertise in molecular biology, especially in virus - based techniques for introducing new genes into specific cell types in the grid - cell circuiIn particular, they are now looking for expertise in molecular biology, especially in virus - based techniques for introducing new genes into specific cell types in the grid - cell circuiin molecular biology, especially in virus - based techniques for introducing new genes into specific cell types in the grid - cell circuiin virus - based techniques for introducing new genes into specific cell types in the grid - cell circuiin the grid - cell circuit.

In one of the experiments, for example, activation of a particular signal at the correct time elicits the appearance of the mesoderm, endoderm and ectoderm — the precursors of all cell types — with a spatial organization similar to that of an embryo.

Certain small molecules in particular have affinity for particular types of cells.

The approach involves reprogramming skin cells into pluripotent stem cells, or cells that can give rise to any other fetal or adult cell type, and then inducing them to differentiate, or transform, into cells that perform a particular function — in this case, secreting insulin.