Sentences with phrase «in pharmacological studies»

This is no different a result from what we find in pharmacological studies.

Now, we can use copper - catalyzed conditions which are applicable to versatile fluoroalkenes to replace fluorine atoms with boron, which opens up a huge range of potential target molecules and should boost the use of fluoroalkenes in pharmacological studies.»

Not exact matches

DHA is an omega - 3 fatty acid that is necessary for brain development and that improves your baby's learning capabilities as he grows older, according to a study in the journal «Pharmacological Research.»

Prosecuting would be a «difficult and unworkable task, as little or no evidence is available regarding [the substances»] pharmacological activities in vivo in humans and expert witnesses may be reluctant to extrapolate data from animal models, in silico or in vitro studies,» lecturer in criminal law Amber Marks told the committee.

Says DiDonato: «We are very happy that our research was able to assist in the pharmacological characterization of RG3039 and contribute to dose selection and exposure estimates for the first studies with RG3039 in human subjects.

Animal studies done in the UK and South Africa found no pharmacological effects of rhino horn — or any other animal horns.

These pharmacological effects typically mirror those originally described for the herbs by the Chinese physicians of 2000 years ago, although modern studies have in some cases revealed new pharmacological benefits that were not previously recognized by TCM doctors.

Specifically, the Mount Sinai study was designed to test whether pharmacological compounds designed to block the function of XPO1 / CRM1 could stop disease progression in mouse models that exhibit some of the characteristics of MS. Researchers found that two chemical agents (called KPT - 276 and KPT - 350) prevented XPO1 / CRM1 from shuttling cargo out of the nucleus of nerve cells, which protected them from free radicals and structural damage.

A newly characterized group of pharmacological compounds block both the inflammation and nerve cell damage seen in mouse models of multiple sclerosis, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published online this week in the journal Nature Neuroscience.

Study results suggest that pharmacological action on these epigenetic alterations may be helpful in slowing disease progression.

In a study published in the April issue of the Journal of Neuroscience, Saint Louis University scientists led by professor of pharmacological and physiological sciences Daniela Salvemini, Ph.D., discovered that drugs targeting the A3 adenosine receptor can «turn off» pain signals in the spinal cord to provide relief from chronic paiIn a study published in the April issue of the Journal of Neuroscience, Saint Louis University scientists led by professor of pharmacological and physiological sciences Daniela Salvemini, Ph.D., discovered that drugs targeting the A3 adenosine receptor can «turn off» pain signals in the spinal cord to provide relief from chronic paiin the April issue of the Journal of Neuroscience, Saint Louis University scientists led by professor of pharmacological and physiological sciences Daniela Salvemini, Ph.D., discovered that drugs targeting the A3 adenosine receptor can «turn off» pain signals in the spinal cord to provide relief from chronic paiin the spinal cord to provide relief from chronic pain.

«It's very interesting work but not practical for clinical treatment of patients,» says Denis Paré, a neuroscientist at Rutgers University in New Jersey who is also studying pharmacological approaches to manipulating fearful memories.

We are now in the process of studying the proteins in the blood - brain barrier that accept pharmacological agents instead of throwing them out.

A study published ahead of print in the The Journal of General Physiology has revealed new insights into Retigabine, a known pharmacological treatment for epilepsy.

They carried out their studies under standardised conditions in 36 different tests, to analyse the molecular pharmacological characteristics of the substances.

For example, this could support large - scale epidemiologic studies or remote pharmacological trials,» said senior and corresponding author David L. Kaplan, Ph.D., Stern Family Professor in the Department of Biomedical Engineering at Tufts School of Engineering.

The new study — published October 18, 2016 in the journal Molecular Psychiatry — combined genetic analysis of more than 9,000 human psychiatric patients with brain imaging, electrophysiology, and pharmacological experiments in mutant mice to suggest that mutations in the gene DIXDC1 may act as a general risk factor for psychiatric disease by interfering with the way the brain regulates connections between neurons.

In their study, the researcher exploited this central position of EZH2 to combat the cancer: They used a pharmacological inhibitor to suppress the activity of EZH2.

Pozzo - Miller reflects that this new research on LM22A - 4, combined with prior studies from the Katz lab, provides hope that at least some neurological and cognitive deficits in individuals with Rett could be improved by pharmacological treatment even after the onset of symptoms.

«When we had the data, we were quite surprised by the amount,» says Roberto Fanelli, one of the study's authors and head of the Department of Environmental Health Sciences at the Mario Negri Institute for Pharmacological Research in Milan.

The results, published in the current issue of Human Molecular Genetics, open the door for pursuing gene editing in nonhuman primates as models for new therapies, including pharmacological, gene - and stem cell - based therapies, said Keith Latham, MSU animal science professor and lead author of the study.

The study team then tested UNC0642, which had more favorable pharmacological features, in a mouse model of PWS.

Gozzi, A. * Schwarz, A., Reese, T., Bertani, S., Crestan, V., Bifone, A. Region - specific effects of nicotine on brain activity: A pharmacological MRI study in the drug - näve rat (2006) Neuropsychopharmacology, 31 (8), pp. 1690 - 1703

Wellman, P.J., Clifford, P.S., Rodriguez, J.A., Hughes, S., Di Francesco, C., Melotto, S., Tessari, M., Corsi, M., Bifone, A., Gozzi, A. Brain reinforcement system function is ghrelin dependent: Studies in the rat using pharmacological fMRI and intracranial self - stimulatioAddiction Biology, 17 (5), pp. 908 - 919 10.

Cell lines provides solution for manufacture of therapeutic and diagnostic protein and for applications in drug screening, pharmacological research and toxicological studies

, Lepore S, Vicentini E, Merlo - Pich E, Bifone A Differential effect of Orexin - 1 and CRF - 1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor yohimbine (2013) Neuropsychopharmacology, 38 (11), pp. 2120 - 2130 8.

Measuring the heart rate is an important read - out in toxicological, pharmacological, and other studies on the cardiovascular system using larval zebrafish.

The Institute's phenotyping platforms are adapted for the study of mutant mice and genetic reference populations but can also be used for preclinical studies including the validation of therapeutic targets as well as pharmacological and toxicological studies in the mouse.

Ease of therapeutic attack — especially the probability of finding a suitable molecule for proof - of - concept pharmacological studies in a timely manner

Freitas et al (2011) performed a systematic search of all studies using non-invasive stimulation in Alzheimer's disease (AD) and reviewed all 29 identified articles; 24 focused on measures of motor cortical reactivity and (local) plasticity and functional connectivity, with 8 of these studies assessing also effects of pharmacological agents, and 5 studies focused on the enhancement of cognitive function in AD.

«Deficient neuron - microglia signaling results in impaired functional brain connectivity and social behavior» Y. Zhan, R.C. Paolicelli, F. Sforazzini, L. Weinhard, G. Bolasco, F. Pagani, A. L. Vyssotski, A. Bifone, A. Gozzi, D. Ragozzino, C.T. Gross Nature Neuroscience 17 (3), 400-4006 (2014) «USPIO - loaded Red Blood Cells as a biomimetic MR contrast agent: a relaxometric study» A. Boni, D. Ceratti, A. Antonelli, C. Sfara, M. Magnani, E. Manuali, S. Salamida, A. Gozzi, and A. Bifone Contrast Media and Molecular Imaging 9, 229 - 236 (2014) «Distributed BOLD and CBV - weighted resting - state networks in the mouse brain» F. Sforazzini, A.J. Schwarz, A. Galbusera, A. Bifone, and A. Gozzi NeuroImage 87, 403 - 415 (2014) «Antimicrobial peptides design by evolutionary multiobject optimization» G. Maccari, M. Di Luca, R. Nifosì, F. Caldarelli, G. Signore, C. Boccardi, and A. Bifone PloS Computational Biology 9 (9): e1003212 (2013) «Differential effect of orexin - 1 and crf - 1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor yohimbine» A. Gozzi, S: Lepore, E: Merlo Pich, and A. Bifone Neuropsychopharmacology 38 (11): 2120 - 2130 (2013) «Water dispersal and functionalization of hydrophobic iron oxide nanoparticles with lipid - modified poly (amidoamine) dendrimers» A. Boni, L. Albertazzi, C. Innocenti, M. Gemmi, and A. Bifone.

Thus, Eph receptor - targeting peptides represent valuable pharmacological tools to study the functional importance of specific Eph receptors in tumors and the nervous system.

Our study aims to gain insight in its pathogenesis, by evaluating multimodal MRI studies in HIV - positive children versus healthy controls, and correlating alterations with neurocognitive, immunological and pharmacological states.

Dopaminergic dysfunction in abstinent dexamphetamine users: Results from a pharmacological fMRI study using a reward anticipation task and a methylphenidate challenge

It is, in fact, one of the most studied plants, with approximately 1,900 medical, pharmacological and chemical reports published so far on the subject of its properties.

In one study, researchers noted that «Curcumin exerts several positive pharmacological effects; these include anti-inflammatory, antioxidant, anti-hypertensive, anti-cancer, antiviral, anti-infective and wound - healing properties.»

In this study, we demonstrated that anthocyanins (cyanidin or cyanidin 3 - glucoside) have the potency of a unique pharmacological function in isolated rat adipocyteIn this study, we demonstrated that anthocyanins (cyanidin or cyanidin 3 - glucoside) have the potency of a unique pharmacological function in isolated rat adipocytein isolated rat adipocytes.

«Given the long and established history of curcumin as a spice and herbal medicine, its demonstrated chemopreventive and therapeutic potential, and its pharmacological safety in model system, curcumin, the bioactive extract of curcumin, promises a great future in human clinical studies designed to prevent and / or delay age - related diseases,» explained the authors of a review on these and other animal studies involving curcumin.

By 1984 Russian scientists had published in excess of 1,500 pharmacological and clinical studies on adaptogenic herbs.

Although the endocannabinoid system regulates the autonomic nervous system, microcirculation, and immunity in the periphery, «Studies to date indicate that the main pharmacological function of the endocannabinoid system is in neuromodulation: controlling motor functions, cognition, emotional responses, homeostasis and motivation» (11, p. 2).

Kubo, M et al; Pharmacological Study on Kefir: a Fermented Milk Product in Caucasus.

Magnesium deficiency can cause important health issues According to a new study in Pharmacological Research, researchers have demonstrated that magnesium (Mg) supplementation significantly improves important health markers.

A 2003 study published in the Journal of Pharmacological Sciences examined the anxiety - abolishing effects of both Ginkgo biloba and Asian ginseng, finding that while both were effective in reducing acute stress, supplementing with Asian ginseng was the most effective in significantly lowering chronic stress.

It has been extensively researched in Europe through chemical analysis, study of pharmacological properties and clinical experimentation.

About Blog The Journal of Neuropsychology publishes original contributions to scientific knowledge in neuropsychology including clinical and research studies with neurological, psychiatric and psychological patient populations in all age groups, behavioural or pharmacological treatment regimes, cognitive experimentation and neuroimaging.

The new generation of pharmacological treatment approaches to dementia attract most attention, but this study is a timely reminder that simple, early, psychosocial interventions with caregivers can be cost effective in maintaining patients at home, while not increasing strain on relatives.

However, when stratified by quality of studies, the Cochrane review found no statistically significant evidence in methodologically robust RCTs that exercise was more effective than psychological or pharmacological therapies.46 Nevertheless, we still found that depressive symptoms are associated with lower PA levels in individuals at high risk of CVD, which highlights the importance of screening and optimising conventional depression management48 to reduce depressive symptoms, which could help lower CVD risk.3 4