Sentences with phrase «in phase i trials»

Juno is developing its immunotherapy product candidate, JCAR017, which is in a Phase I trial, studying patients with B - cell Non-Hodgkin Lymphoma [NHL].

It tells the story of «the guinea pigs»» the people most likely to be research subjects in Phase I trials, which test the safety of a drug under development by giving it to healthy subjects and examining any side effects they experience.

«Results in Phase I trial targeting cancer stem cells.»

In phase I trials, researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.

NewLink Genetics of Ames, Iowa, has a second vaccine in a phase I trial that consists of a crippled vesicular stomatitis virus (VSV), which infects livestock, with the gene for the Ebola virus surface protein.

«RNA interference drug demonstrated activity and safety in phase I trial.»

Through CRI's Clinical Accelerator program, two new checkpoint inhibitor drugs, MEDI4736 (anti-PD-L1) and tremelimumab (anti-CTLA-4), are being tested in a phase I trial for patients with six different cancer types, including colorectal cancer, cervical cancer, head and neck cancer, kidney cancer, lung cancer, and ovarian cancer.

[27] Besides BMS - 936558 (Nivolumab), another humanized anti-PD1 antibody, MK - 3475 (Lambrolizumab), has shown activity and acceptable toxicity in a phase I trial with metastatic melanoma.

A combination of the indoleamine 2,3 - dioxygenase 1 (IDO1) inhibitor epacadostat with the anti — programmed death ligand 1 (PD - L1) antibody durvalumab was well tolerated in a phase I trial of patients with multiple solid tumor types.

The multikinase angiogenesis inhibitor pazopanib was well tolerated and exhibited some responses in pediatric patients with soft - tissue sarcomas and other refractory solid tumors in a phase I trial.

Not exact matches

The drug, with the unwieldy name ceftolozane / tazobactam, has completed Phase 3 clinical trials and could prove particularly effective in dealing with pseudomonas — bacteria usually acquired in hospitals that cause serious interabdominal and urinary tract infections, ultimately resulting in death in some cases.

In a research and strategy update, Novo said it will initiate a phase 3 clinical trial program with once - weekly subcutaneous semaglutide in obesity in the first half of 201In a research and strategy update, Novo said it will initiate a phase 3 clinical trial program with once - weekly subcutaneous semaglutide in obesity in the first half of 201in obesity in the first half of 201in the first half of 2018.

During the sentencing phase of Tsarnaev's trial in federal court in Boston, his lawyers have been trying to paint him as a mostly normal American kid who fell under the spell of his now - deceased older brother, ultimately joining him in the 2013 bombing of the Boston Marathon.

The jury spent a total of just 14 hours in the penalty phase of the trial after finding Tsarnaev guilty on all 30 criminal counts, but an automatic appeal means his case will drag on.

The startup is in the midst of several clinical trials and completed a 52 - week Phase II clinical trial of an osteoarthritis treatment in July.

Acceleron is also advancing its neuromuscular franchise with two distinct Myostatin + agents, ACE - 083 and ACE - 2494, and a pulmonary program with a Phase 2 trial of sotatercept planned in pulmonary arterial hypertension.

Inovio's vaccine against HPV is currently in Phase II clinical studies, and Kim says «about 50 percent» of the subjects in that trial are defeating the disease.

«You look at a lot of ideas, rejecting most of them, flirting with a few, and then — hopefully — settling in for a trial phase with the most attractive and well - rounded option,» he writes in his book.

In November, the company announced that the results of a Phase III trial of solanezumab «were not what we had hoped for.»

Regeneron has 11 experimental treatments in Phase II or Phase III clinical trials.

The case is now in the discovery phase of trial and likely to be settled; he has denied wrongdoing.

The combo is being used in phase III clinical trials.

According to PhRMA, there are more than a dozen experimental treatments that are still in phase 3, the latest stage of clinical trials before companies present their data to the FDA.

Trimel expects to complete Phase 2 trials in the first half of the year.

This year that newsworthy moment, in my view, had nothing to do with the latest Phase III drug trial, pharma merger, or biotech discovery.

Early phase clinical trials in Australia are 28 % cheaper than the USA before tax incentives, and 60 % cheaper after tax incentives.

More than 4,000 individuals have voluntarily received the rVSV - ZEBOV vaccine as part of the Phase 3 trial which began in March, according to Merck.

Two out of the six obesity projects currently in Phase 1 trials are expected to move to Phase 2 next year, Novo said.

In a research and strategy update, Novo said it planned to start a final phase 3 clinical trial program with once - weekly subcutaneous semaglutide in obesity in the first half of 201In a research and strategy update, Novo said it planned to start a final phase 3 clinical trial program with once - weekly subcutaneous semaglutide in obesity in the first half of 201in obesity in the first half of 201in the first half of 2018.

Ms. Albarus testified in both phases of Malvo's trial.

Amicus has a drug in phase 2 trials that leverages their advanced enzyme replacement chaperone platform.

Omecamtiv mecarbil is the subject of GALACTIC - HF, an international Phase 3 clinical trial in patients with heart failure.

The company's lead product candidate, dilanubicel (NLA101), is currently being evaluated in two ongoing Phase 2 clinical trials in adult and pediatric patients with hematologic malignancies undergoing an allogeneic transplant and adult patients receiving high dose chemotherapy for Acute Myeloid Leukemia.

Cassidy said in the next phase of the trial they hope to get up to 300 balloons forming a ring on the 40th parallel south from New Zealand through Australia, Chile, Uruguay, Paraguay and Argentina.

The drug, lefamulin, is in phase three trials, with some results coming later this year.

And now, Lundbeck and partner Otsuka's experimental treatment for improving cognition in Alzheimer's patients has failed two more phase 3 trials, likely ending any remaining hopes for the drug.

Allergan and Paratek Pharmaceuticals are celebrating the success of sarecycline, an experimental acne treatment that met the primary endpoints in a pair of crucial phase 3 clinical trials.

«The positive efficacy results observed in the pivotal phase 3 clinical trials indicate that sarecycline can be an effective treatment option for patients with moderate to severe acne,» said Allergan R&D chief David Nicholson in a statement.

The results, which mirror those of similar, small - scale studies of the illegal drug in recent years, come as MDMA is about to enter larger, Phase 3 trials this summer.

MSDC - 0602K is currently being evaluated in a Phase 2b clinical trial.

The company's lead program, now in phase I clinical trials, is a differentiated PPAR gamma agonist (MIN - 102) that has potential in multiple CNS indications.

Cambridge, MA — March 30, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that it has enrolled and dosed the first patient in its Phase 1b clinical trial of light - activated AU - 011, an investigational, first - in - class targeted therapy in development for the treatment of ocular melanoma, a rare and life - threatening disease.

Otezla, meanwhile, showed that it could hit its own 20 mark in a Phase IIIb trial.

Defense attorneys pointed to Tamerlan's relationship with his wife to demonstrate his ability to influence his younger brother Dzhokhar, as they began their case Monday in the sentencing phase of Dzhokhar's trial.

For the second time in 5 months, Juno Therapeutics has put a clinical hold on a Phase II trial of JCAR015 in adult patients with relapsed or refractory B - cell acute lymphoblastic leukemia due to patient deaths.

One of Juno's rivals, Kite Pharma, yesterday said it had completed its enrollment of 72 patients with diffuse large B - cell lymphoma in the Phase II portion of the ZUMA - 1 trial, designed to assess KTE - C19.

Downside appears limited after the secondary and validation of their technology, while advancement of their pipeline (IgG4 - RD phase 3 trial initiation, data from phase 2 study in SLE and phase 1 study in AML) should keep Wall Street interested.

Dr. Newman added that rival CAR T cell therapy developer Kite Pharma was still likelier to generate more revenue than Juno with KTE - C19, which last week completed patient enrollment in the Phase II portion of the ZUMA - 1 trial in patients with diffuse large B - cell lymphoma.

Competitive advantages, including scale, existing patents on blockbuster drugs (such as Enbrel), broad geographical and product diversification, R&D, and a strong pipeline of drugs (16 compounds in Phase III trials) give this firm the strengths it needs to fight risks like competition, litigation, and regulation.

In a March 16 research note, Andrew Fein, an analyst at H.C. Wainwright & Co., reported that OvaScience (OVAS: NASDAQ) shifted its focus back to research and development, after interim data from the first 20 patients in its Phase 1 trial of OvaPrime showed no signs of efficacy despite indicating safety and tolerabilitIn a March 16 research note, Andrew Fein, an analyst at H.C. Wainwright & Co., reported that OvaScience (OVAS: NASDAQ) shifted its focus back to research and development, after interim data from the first 20 patients in its Phase 1 trial of OvaPrime showed no signs of efficacy despite indicating safety and tolerabilitin its Phase 1 trial of OvaPrime showed no signs of efficacy despite indicating safety and tolerability.