Sentences with phrase «in plasma cells»

Myeloma — also referred to as multiple myeloma or plasma cell myeloma — is a cancer that originates in plasma cells, a type of white blood cell that make antibodies.

Myeloma is a bone marrow cancer that starts in the plasma cells.

Myeloma — also referred to as multiple myeloma or plasma cell myeloma — is a cancer that originates in plasma cells, a type of white blood cell that makes antibodies.

These 2 transitions are coordinated by 2 transcriptional repressors: Bcl - 6, the master regulator of the germinal center, and Blimp - 1, which regulates the transcriptional program in plasma cells.»

In vitro experiments and high - throughput RNA sequencing revealed that CTCF deletion profoundly altered the B lymphocyte transcriptional program, shifting cells from a gene expression profile typical of the germinal center to one more similar to that seen in plasma cells.

Analysis of microbial sequences in plasma cell - free DNA for early - onset breast cancer patients and healthy females — Yu - Feng Huang — BMC Medical Genomics

In lymphoma, the cancerous cells are less mature than those in plasma cell tumors.

Not exact matches

Those who ate the diet higher in fiber had lower levels of both plasma glucose (blood sugar) and insulin (the hormone that helps blood sugar get into cells).

** The immunological defense system of the soft mucosa, which may produce antibacterial and antiviral proteins such as lysozyme, also found in mothers milk, and plasma cells, which secrete immunoglobulin antibodies.

Cells in mom's gut watch what's coming through and if there's an infectious cell, a special cell in mom's gut called a plasma cell heads to the breast and helps the breast make SIgA in the milk to protect the baby.

Differences in release of insulin and other pancreatic and gut hormones have also been observed between breastfed and formula - fed infants, with formula feeding leading to higher plasma levels of insulin which in turn would stimulate fat deposition and early development of adipocytes, the cells that store fat (18).

Some studies are now showing that children with ADHD may have lower concentrations of polyunsaturated fatty acids (PUFAs), particularly Omega - 3 fatty acids in their red blood cells and plasmas, and that supplementing with Omega 3 may relieve some of the symptoms and behaviors that cause them the most trouble.

The composition of your blood also changes, creating a higher ratio of plasma to red blood cells than in non-pregnant women.

A growing body of research indicates that the B2M - MHC I complex, which is present in all cells in the body except red blood cells and plasma cells, can act in the brain in ways not obviously related to immunity — guiding brain development, shaping nerve cell communication, and even affecting behavior.

Plasma membrane Ca2 + - ATPases (PMCAs) are present in virtually all types of cells and transport Ca2 + to the extracellular space.

«The problem with plasma cell - free liquid biopsy in particular is that the amount of wild - type [DNA] can be very, very high, and so keeping that really rare signal from being swamped out by the wild - type... is key,» says Dawne Shelton, R&D manager for in vitro diagnostic products at Bio-Rad in Hercules, California.

Thus, transport of peptide — MHC II complexes by DCs not only accomplishes transfer from late endocytic compartments to the plasma membrane, but does so in a manner that selectively concentrates TCR ligands and costimulatory molecules for T cell contact.

An isoform of amphiphysin 2 concentrated at T - tubules induced tubular plasma membrane invaginations when expressed in nonmuscle cells.

But in multiple myeloma, plasma cells grow out of control in the bone marrow, crowding out healthy cells.

Healthy plasma cells produce antibodies that fight infection in the body, but myeloma cells produce high levels of abnormal antibodies that, when the cancer cells accumulate, they crowd out production of other important blood cells, both red and white.

The study, «Lenalidomide (LEN) maintenance (MNTC) after high - dose melphalan and autologous stem cell transplant (ASCT) in multiple myeloma (MM): A meta - analysis (MA) of overall survival (OS),» is ASCO 2016 abstract no. 8001 and will be discussed during the Hematologic Malignancies — Plasma Cell Dyscrasia oral abstract session Friday, Juncell transplant (ASCT) in multiple myeloma (MM): A meta - analysis (MA) of overall survival (OS),» is ASCO 2016 abstract no. 8001 and will be discussed during the Hematologic Malignancies — Plasma Cell Dyscrasia oral abstract session Friday, JunCell Dyscrasia oral abstract session Friday, June 3.

Dr. Jiang found that LPCAT3 deficiency significantly reduces polyunsaturated PC levels in the plasma membrane of the cells that line the intestines, which in turn reduces lipid absorption and decreases levels of lipids (cholesterol, triglyceride, and phospholipid) in circulation.

Being overweight or obese has been known to increase the risk of multiple myeloma, a cancer of the plasma cells in the blood and bone marrow that develops more often after age 60.

In multiple myeloma, normal plasma cells transform into malignant myeloma cells and produce large quantities of toxic abnormal immunoglobulin called monoclonal protein that can damage multiple organs.

Multiple myeloma is preceded by a blood disorder called monoclonal gammopathy of undetermined significance (MGUS) in which abnormal plasma cells produce many copies of an antibody protein.

Multiple myeloma is a cancer of plasma cells in the blood that causes tumor growths in bone marrow.

They gave DON and an altered derivative, dubbed 5c, intravenously to two monkeys and, 30 minutes later, measured the amount of the drugs in the monkeys» cerebrospinal fluid and circulating plasma, which is the liquid portion of blood that remains after blood cells, platelets and other cellular components are removed.

Here they used the UK - developed EPOCH «particle - in - cell» code, where particles are modeled as «chunks» that describe the bigger reality of the dynamics of the plasma system.

They also gave old mice infusions of young blood plasma (the liquid component of blood containing proteins and hormones but no cells), which significantly improved their performance in learning and memory tests.

To simulate the results from a hypervelocity impact plasma, researchers used a method called particle - in - cell simulation that allows them to model the plasma and the electromagnetic fields simultaneously.

In a new paper, he and colleagues reveal that host cells sequester viral proteins away from the plasma membrane within the cell, thus preventing viruses from spreading.

Epidermal growth factor receptor (EGFR) mutations found in the circulating free tumor DNA (ctDNA) from the plasma of advanced non-small cell lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient - matched tumor tissue DNA.

The Brain Trauma Indicator measures blood plasma levels of the UCH - L1, a protein scientists believe helps dispose of cellular waste in the brain, and GFAP, a structural protein found in non-neuronal cells called astrocytes.

However, this change was not overtly related to stress in beta cells, since plasma insulin levels were not lower following acute lack of sleep.

Other plasma - activated solutions have previously been shown to induce reactive oxygen species within cells, but these were not detected in plasma - activated Lactec (PAL)- treated cells, suggesting an alternative mechanism triggered cell death.

Previous work by the researchers developed plasma - activated cell culture medium as a form of chemotherapy, but selected Ringer's solution in the present work because of its simpler composition and likelihood of forming less complex reaction products.

We show that β - arrestins coordinate both processes by recruiting PDEs to activated β2 - adrenergic receptors in the plasma membrane of mammalian cells.

In a related editorial, Niklhil C. Munshi, M.D., of the Dana - Farber Cancer Institute, Boston, writes: «The study by Landgren et al has brought clarity to the risk of AO [Agent Orange] exposure and plasma cell disorder.

In addition, adds Dr. Ramiro, «after completing this program, the B lymphocytes can differentiate into plasma cells, which no longer proliferate but instead secrete large amounts of antibodies.

Multiple myeloma is a cancer of the infection - fighting plasma cells, part of the immune system found mainly in bone marrow.

Low energy electrons are ubiquitous and are known to play important role in variety of phenomena relevant to astrochemistry (where they participate in synthesis of new molecules), in radiation biology (where they cause chemical changes in living cell, plasma chemistry), atmospheric chemistry, radioactive waste management and nanolithography — to name but a few.

Research suggests that very scarce chemical cues can trigger physical changes in the cell, including remodeling the plasma membrane and recruiting cytoskeletal machinery, to transform the dichty from a fat, happy cell to an elongated cell with a distinct front and rear end, ready to migrate.

They demonstrated that in the absence of SERT, antidepressants accumulate gradually in the plasma membrane microdomains of glioma cells.

In the final step in bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systemIn the final step in bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systemin bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systemin so doing have uncovered a novel class of pattern - forming mechanism in biological systemin biological systems.

The coordinated assembly and disassembly of actin in the cell cortex, which lies just beneath the plasma membrane, generates cortical actin waves that are crucial for important cell functions including migration and cell polarity.

Gαs went from lipid rafts to nonraft regions of the plasma membrane in the glioma cells, which enhanced its signaling ability.

In the 1990s the U.S. Food and Drug Administration approved its use in the treatment of both multiple myeloma (a form of cancer that affects plasma cells) and the complications of leprosIn the 1990s the U.S. Food and Drug Administration approved its use in the treatment of both multiple myeloma (a form of cancer that affects plasma cells) and the complications of leprosin the treatment of both multiple myeloma (a form of cancer that affects plasma cells) and the complications of leprosy.

Plasma from old mice didn't have a strong effect when injected into young mice genetically engineered to lack VCAM1 in certain blood - brain barrier cells.

In the process, the plasma membrane receptor Fas (CD95) is key; this cell receptor occurs in almost all human cells and is involved in programmed cell death (apoptosisIn the process, the plasma membrane receptor Fas (CD95) is key; this cell receptor occurs in almost all human cells and is involved in programmed cell death (apoptosisin almost all human cells and is involved in programmed cell death (apoptosisin programmed cell death (apoptosis).

«There was some skepticism about whether a CD19 - directed therapy would work in this disease, since nearly all of these patients» cancerous plasma cells do not express CD19,» said the study's senior author, Edward Stadtmauer, MD, chief of Hematologic Malignancies and a professor of Hematology / Oncology in Penn's Abramson Cancer Center and Perelman School of Medicine.