Sentences with phrase «in plasma membrane»

Triggered micropatterning of IFNAR1 (green) in the plasma membrane of living cells followed by ligand - induced association of IFNAR2 (red)(8).

A part of the explanation might be the changes in plasma membrane lipid composition that accompany the secretion process and lead to changes in signaling properties of the receptors present at the plasma membrane (IGF - 1R, IR).

PLC - beta is a 150 kDa enzyme that catalyzes the hydrolysis of phosphoinositide PtdIns (4,5) P2 located in the plasma membrane into diacylglcyerol (DAG) and Ins (1,4,5) P3.

It is ideal for studying events in the plasma membrane of living cells with high axial resolution.

«If one protein is present in the nucleus but also in the plasma membrane, it might have different functions in those compartments.»

Rothman immediately realised the importance of the result, and proposed the «SNARE hypothesis» for vesicle transport and exocytosis as a general process in all cell types: vesicle proteins specifically bind to target proteins in the plasma membrane to form a «v - t» complex which is necessary for vesicle and membrane fusion to proceed.

Only three proteins stuck: VAMP / synaptobrevin, syntaxin and a third called SNAP - 25 (which dwells mainly in the plasma membrane).

I was studying a molecule involved in plant immunity that affected lipid fluidity in the plasma membrane.

Decreased amounts of the lipid family of phosphoinositides (PIPs) in the plasma membrane have been shown to cause cytokinesis defects.

Recent successful steps in this direction were for example identifying that hydrophobic mismatch and electrostatic interaction with the lipid PIP2 are driving the formation of active complexes of the SNARE protein synatxin - 1 in plasma membrane.

When efr3 was knocked out in S. pombe, PIP levels were reduced in the plasma membrane.

Probing protein heterogeneity in the plasma membrane using PALM and pair correlation analysis.

For the type I interferon (IFN) receptor (IFNAR) as a paradigm for functional plasticity, we have, within the first funding period, established single molecule imaging techniques for monitoring receptor assembly and dynamics in the plasma membrane of living cells.

These events occur when specific extracellular molecules bind to receptor proteins in the plasma membrane known as receptor tyrosine kinases and heterotrimeric G - protein - coupled receptors.

The scientists observed that these proteins move extremely slowly in the plasma membrane of the yeast and discovered how they travel through the membrane to reach the islands.

New HIV - 1 particles assemble at specialized sites in the plasma membrane that are enriched in PIP2, a phospholipid component of the membrane that recruits a viral protein called Pr55Gag (Gag) that directs HIV - 1 assembly.

Unfolded proteins create stress on the cell, and you potentially create situations where you now put less assembled proteins in the plasma membrane.

They demonstrated that in the absence of SERT, antidepressants accumulate gradually in the plasma membrane microdomains of glioma cells.

We show that β - arrestins coordinate both processes by recruiting PDEs to activated β2 - adrenergic receptors in the plasma membrane of mammalian cells.

«We found that neratinib triggers a seismic event in the plasma membrane where not only are ERBB family receptors such as EGFF and HER2 degraded, but other related receptors in the membrane are brought along for the ride,» said Dent.

Dr. Jiang found that LPCAT3 deficiency significantly reduces polyunsaturated PC levels in the plasma membrane of the cells that line the intestines, which in turn reduces lipid absorption and decreases levels of lipids (cholesterol, triglyceride, and phospholipid) in circulation.

These findings support the concept that glucagon exerts its regulatory action in the liver by stimulating adenyl cyclase activity in the plasma membrane.

This protein goes by the name of BvSUT1 and is found in the plasma membranes of companion cells.

Not exact matches

Of course, if it's a fat - soluble drug they can get more into breast milk than in plasma because they can get and cross that fatty membrane.

So far, «in my view, his most important achievement [s] were his initial demonstration and further exploration of the centrosome as a critical hub on the route followed by retroviruses between the plasma membrane and the nucleus.

Plasma membrane integrity and the display of phosphatidylserine on the plasma membrane's extracellular face are both hallmarks of apoptosis, and are used in this kit to distinguish apoptosis from necPlasma membrane integrity and the display of phosphatidylserine on the plasma membrane's extracellular face are both hallmarks of apoptosis, and are used in this kit to distinguish apoptosis from necplasma membrane's extracellular face are both hallmarks of apoptosis, and are used in this kit to distinguish apoptosis from necrosis.

Plasma membrane Ca2 + - ATPases (PMCAs) are present in virtually all types of cells and transport Ca2 + to the extracellular space.

In the worm, only harmless concentrations of hydrogen peroxide are generated and this process occurs at different rates at both sides of the plasma membrane.

Thus, transport of peptide — MHC II complexes by DCs not only accomplishes transfer from late endocytic compartments to the plasma membrane, but does so in a manner that selectively concentrates TCR ligands and costimulatory molecules for T cell contact.

An isoform of amphiphysin 2 concentrated at T - tubules induced tubular plasma membrane invaginations when expressed in nonmuscle cells.

«In order to avoid other interfering species present in plasma, the bead surface was chemically modified with an antibody that recognizes and binds with a specific target protein — for example, a protein receptor — present on the exosome membranIn order to avoid other interfering species present in plasma, the bead surface was chemically modified with an antibody that recognizes and binds with a specific target protein — for example, a protein receptor — present on the exosome membranin plasma, the bead surface was chemically modified with an antibody that recognizes and binds with a specific target protein — for example, a protein receptor — present on the exosome membrane.

In a new paper, he and colleagues reveal that host cells sequester viral proteins away from the plasma membrane within the cell, thus preventing viruses from spreading.

Research suggests that very scarce chemical cues can trigger physical changes in the cell, including remodeling the plasma membrane and recruiting cytoskeletal machinery, to transform the dichty from a fat, happy cell to an elongated cell with a distinct front and rear end, ready to migrate.

In the final step in bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systemIn the final step in bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systemin bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systemin so doing have uncovered a novel class of pattern - forming mechanism in biological systemin biological systems.

The coordinated assembly and disassembly of actin in the cell cortex, which lies just beneath the plasma membrane, generates cortical actin waves that are crucial for important cell functions including migration and cell polarity.

Gαs went from lipid rafts to nonraft regions of the plasma membrane in the glioma cells, which enhanced its signaling ability.

Here we used this approach to show that newly synthesized connexin43 was transported predominantly in 100 - to 150 - nanometer vesicles to the plasma membrane and incorporated at the periphery of existing gap junctions, whereas older connexins were removed from the center of the plaques into pleiomorphic vesicles of widely varying sizes.

In the process, the plasma membrane receptor Fas (CD95) is key; this cell receptor occurs in almost all human cells and is involved in programmed cell death (apoptosisIn the process, the plasma membrane receptor Fas (CD95) is key; this cell receptor occurs in almost all human cells and is involved in programmed cell death (apoptosisin almost all human cells and is involved in programmed cell death (apoptosisin programmed cell death (apoptosis).

The predictors include «Online Mendelian Inheritance in Man» (OMIM, a list of genetically caused diseases), receptors, kinases, growth factors, transcription factors, tissue specific, plasma membrane localization, nuclear localization and conversation index.

In most cases, newly synthesised proteins destined for the plasma membrane are synthesised in the ER and use the classical secretory pathway (ER > ER exit sites > Golgi > PM)(14In most cases, newly synthesised proteins destined for the plasma membrane are synthesised in the ER and use the classical secretory pathway (ER > ER exit sites > Golgi > PM)(14in the ER and use the classical secretory pathway (ER > ER exit sites > Golgi > PM)(14).

We choose this comparative approach because in contrast to yeast, where the active, assembled holoenzyme in the vacuolar membrane is the default state, the insect plasma membrane V - ATPase is normally inactive and is activated by hormone - induced reassembly.

This project aims to elucidate the role of membrane recycling for the lateral segregation of integral membrane proteins into dynamic microcompartments in the budding yeast plasma membrane (PM).

On the other hand, we focus on in vivo / in situ studies using the yeast V - ATPase in the vacuolar membrane as well as the insect plasma membrane V - ATPase.

«Creating a realistically complex neuronal plasma membrane mixture was quite challenging and highlighted a number of gaps in the current understanding of membrane biology,» Ingolfsson said.

Proteomic identification of protein targets for 15 - deoxy - d - prostaglandin j (2) in neuronal plasma membrane.

Delivery of newly synthesized proteins to the plasma membrane and the extracellular medium takes place in the membrane organelles of the secretory pathway.

The extracellular leaflet of the plasma membrane is not characterized by unique molecular targets but by overexpressed antigens that are relatively down regulated in healthy cells.

Junctophilin - 4, a component of the endoplasmic reticulum — plasma membrane junctions, regulates Ca2 + dynamics in T cells.

Possible role of deep tubular invaginations of the plasma membrane in MHC - I trafficking.

Altered cGMP Dynamics at the Plasma Membrane Contribute to Diarrhea in Ulcerative Colitis.