Not exact matches
Women with
precancer or cancer were most likely to have particular versions of the viral gene E7, which researchers are now interested
in targeting.
To address this gap
in knowledge, Mirabello and Schiffman teamed up with co-senior author Robert Burk of Albert Einstein College of Medicine to sequence the whole genomes of 5,570 HPV16 - infected cell and tissue samples from women around the world and to identify associations between HPV16 genetic variants and the risk of cervical
precancer and cancer.
Screening histories preceding cervical cancers (n = 623) and
precancers (n = 5,369) were examined to assess the relative contribution of the Pap test and HPV test components
in identifying cases.
An HPV test,
in which doctors test a cervicovaginal specimen for the presence of the nucleic acids of carcinogenic types of HPV, is more sensitive than the Pap test (a microscopic examination of exfoliated cells) for detection of
precancers.
However, the researchers determined that two proteins can play a significant role
in ruling out
precancer and cancer.
More than a dozen experimental clinical therapies and vaccines have been developed from research from the Weiner laboratory, including the first Zika vaccine
in clinical trials, as well as a novel immunotherapy for HPV - associated cancer and
precancer.
«We understand that people get infections, we understand that people develop low - grade abnormalities, but we also understand that the amount of
precancer is very low
in these populations,» says Wheeler, who has conducted extensive research on HPV infection and cervical cancer.
Any woman with a uterus who takes systemic estrogen of any type, such as a cream, patch, or pill, must counterbalance the estrogen with progesterone, delivered orally as a pill, to prevent buildup of excess tissue
in the uterine lining, which may turn into
precancer or cancer.
delivered orally as a pill, to prevent buildup of excess tissue
in the uterine lining, which may turn into
precancer or cancer.