Sentences with phrase «in preclinical development»

Dr Eddy Rommel joined the PDT of TBVI in 2009 as a consultant in preclinical development.

GLN - 1001 is currently in preclinical development, where it has been shown to dramatically prolong survival in patient derived xenograft animal models of glioblastoma.

His work has led to the development of two potential malaria vaccines, one of which is in clinical trials in the US and the other in preclinical development.

As per the terms of the agreement, Roche gains an exclusive worldwide license to PTC's SMA programme, which includes three compounds currently in preclinical development, as well as potential back - up compounds.

Roche (SIX: RO, ROG; OTCQX: RHHBY) and Prothena Corporation plc (NASDAQ: PRTA), announced today that they have entered into a worldwide collaboration to develop and commercialize antibodies that target alpha - synuclein, including PRX002... which is currently in preclinical development and is expected to enter Phase 1 clinical trials in patients with Parkinson's disease in 2014.

These programs, including an IDO1 inhibitor in preclinical development were licensed to Pfizer in 2014.

Not exact matches

Alder is additionally evaluating ALD1910, a preclinical product candidate also in development as a migraine prevention therapy.

Then follow up persistently, counsels Kate Stuart, founder and director of preclinical development at Symic Biomedical, a startup in the San Francisco Bay Area.

Frost and Sullivan's survey showed that in 2002, the top 20 pharmaceutical companies spent about a third of their R&D budgets on preclinical development.

«There are significant opportunities in outsourcing to China and India, particularly in respect to drug discovery, early development, and the preclinical and clinical sectors,» Burrill says.

«Collaborations with academia with renown expertise in antibiotics like the UIC team help us for this preclinical development,» said Philippe Villain - Guillot, co-founder and chief executive officer of Nosopharm.

«Improving the design, conduct, and reporting of preclinical research is of the utmost priority if we are to move ahead, with all due haste, in the development of novel treatments across a range of diseases.»

In his current role, he combines population research and functional genomics strategies to inform drug development from preclinical through phase 3 trials.

Preclinical studies suggest that Cdk5 is a gene that is important for the normal wiring of the brain during early development and may be involved in some neurodegenerative disorders, including ALS, Parkinson's and Alzheimer's disease.

Overall, this work illustrates that better understanding the basic biology of the immune system in preclinical models may open up a window for the development of novel treatments for human autoimmune disease.

The third kind of marker Perera calls «preclinical,» meaning that a medical development may be in the offing.

Hua's extensive work in Krainer's lab, in collaboration with Ionis, led to the identification and preclinical development of nusinersen, a snippet of modified RNA called an antisense oligonucleotide that intervenes in the splicing process to ensure that SMN2 expresses the full - length SMN protein.

It is currently in the preclinical stages of development.

Preclinical studies in mice and human cells suggested that the removal of SnCs significantly reduced the development of post-traumatic OA and related pain and created a prochondrogenic environment for new cartilage to grow and repair joints.

Our finding of similarity in clinical progression between human patients and Huntington's disease monkeys suggests monkeys could become a preclinical, large animal model for the development of new treatments.»

In addition, EATRIS will seek to identify inconsistencies in the national regulatory frameworks while offering consultation on preclinical vaccine development (WP16In addition, EATRIS will seek to identify inconsistencies in the national regulatory frameworks while offering consultation on preclinical vaccine development (WP16in the national regulatory frameworks while offering consultation on preclinical vaccine development (WP16).

GLP regulations and guidelines for the conduct of preclinical testing ensure the quality and integrity of data submitted in support to the development of new treatments, foster mutual acceptance of data in the international community, serves to minimise redundant testing, minimize animal use and maximise protection of human health.

Our scientists engage with you in the design and execution of your preclinical drug development program using our AAALAC approved animal facilities, proprietary animal models, and extensive capabilities.

PsychoGenics has pioneered the translation of rodent behavioral responses into robust, high throughput, high content phenotyping and its drug discovery platforms, SmartCube ®, NeuroCube ®, and PhenoCube ® have led to shared risk partnerships with major pharma companies such as Sunovion and Roche and resulted in the discovery of several novel compounds now in clinical trials or advanced preclinical development.

EATRIS involvement in TRANSVAC2 will include primarily the development of a regulatory platform for preclinical, marketing authorisation and pharmacovigilance for clinical trials.

Seres Therapeutics, Inc. (NASDAQ: MCRB) today announced that new preclinical data supporting the development of microbiome therapeutics for immuno - oncology (leveraging gut microbiota to impact tumor immunotherapy) 1 will be presented today by Sceneay et al in the late breaking poster session at the 2018 American Association for Cancer Research Annual Meeting (AACR) in Chicago.

The company delivers in situ target engagement studies to accelerate preclinical and clinical drug discovery and diagnostics development.

She is CEO of PsychoGenics Inc., a profitable preclinical CNS service company, CEO of PGI Drug Discovery LLC, a company engaged in psychiatric drug discovery with three partnered Phase II clinical programs and Adjunct Associate Professor of Neuroscience at Mount Sinai School of Medicine, Dr. Leahy has more than 25 years of experience in drug discovery, clinical develop and business development for pharmaceutical and biotechnology companies, including extensive knowledge of technology assessment, licensing, mergers and acquisitions, and strategic planning.

Non-small cell lung cancer nanoparticles pass the next stage of development in preclinical tests.

These risks and uncertainties include, among others, those relating to our ability to obtain financing and to form collaborative relationships, uncertainty regarding potential future deterioration in the market for auction rate securities which could result in additional permanent impairment charges, our ability to develop and market diagnostic products, the level of third party reimbursement for our products, risks related to preclinical and clinical development of pharmaceutical products, including the identification of compounds and the completion of clinical trials, the effect of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights for our products, dependence on collaborative relationships, the effect of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.

She graduated from Trinity with honors in chemistry and participated in a summer internship in Pharmacology and Preclinical Development at Tularik Inc. (currently Amgen) in South San Francisco.

All this information is necessary before preclinical safety testing and product development for an AMD therapy in humans can take place.

Argos has also developed an interferon - neutralizing antibody for systemic lupus and has developed a CD83 Soluble Protein for Transplant Rejection / Autoimmune Disorders in late preclinical development.

Having a strong R&D department with great experience and expertise in drug development, animal model and assay development and preclinical efficacy evaluation, the contribution of Biomedcode has been greatly valued by our partners, as documented by our participation in several collaborative research projects.

Preclinical studies suggested poor bioavailability with a consequent in vivo ineffectiveness for compound 182a [2, 97], while compound 182b entered clinical trials, unfortunately its development was soon suspended [98, 99].

Our group is specifically working on improvement of islet isolation and transplantation protocols in clinical practice and the development of novel therapeutic options in the field of beta cell replacement with a clear translational «bench to bedside» approach by linking experimental research with preclinical and clinical work:

In favorable cases, this will result in short - circuiting of the preclinical phase of the drug development [3, 4In favorable cases, this will result in short - circuiting of the preclinical phase of the drug development [3, 4in short - circuiting of the preclinical phase of the drug development [3, 4].

While the long - term safety data for the first generation CXCR4 antagonists are not yet available, several new compounds are under preclinical development in an attempt to provide safer and more efficient treatment options for HIV and cancer patients.

Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.

In order to efficiently evaluate the newly designed vaccine candidates before testing them in clinical trials there is a need for development of reliable preclinical modelIn order to efficiently evaluate the newly designed vaccine candidates before testing them in clinical trials there is a need for development of reliable preclinical modelin clinical trials there is a need for development of reliable preclinical models.

This model offers unique capabilities for preclinical assessment of thrombosis risk in a patient - specific manner, including efficacy testing of anti-thrombotic agents, elucidation of mechanism of action, and, potentially, biomarker identification, all providing a much - needed platform for drug discovery and development.

In collaboration with the University of Massachusetts Medical School (UMMS) and Auburn University (AU), Lysogene is developing IND - supporting preclinical studies using AAV gene therapy technology to translate the initial proof of concept into a viable drug development program to the benefit of patients in urgent neeIn collaboration with the University of Massachusetts Medical School (UMMS) and Auburn University (AU), Lysogene is developing IND - supporting preclinical studies using AAV gene therapy technology to translate the initial proof of concept into a viable drug development program to the benefit of patients in urgent neein urgent need.

The organoid course complements the institution's mission by helping fill in the gap between preclinical drug development and human trials.

«The initiation of the NPT088 Phase 1b trial is supported by a substantial preclinical development program and the recent successful completion of a Phase 1a study in healthy volunteers.

Scientists and vaccine developers involved in EVI projects presented project progress and research findings, highlighting one of the most important areas of EVI's activities; translation of research on diseases of poverty vaccines, focusing on early stages from preclinical to clinical development through harmonisation.

For the main conference on September 25 and 26, the event will be structured around 3 plenary sessions, introduced by keynote speakers: Session 1: The Funder, Developer and Regulator as Partners in Innovation Session 2: Novel approaches in clinical development Session 3: Developing more predictive preclinical tools to better reach proof of concept

In recent years, the lab has actively collaborated with pharmaceutical companies to obtain compounds in early stages of preclinical and clinical developmenIn recent years, the lab has actively collaborated with pharmaceutical companies to obtain compounds in early stages of preclinical and clinical developmenin early stages of preclinical and clinical development.

As the Global HIV Vaccine Product Manager for the US Army, Dr. Ake advances the development of HIV vaccine candidates in preclinical and early clinical studies.

Previously we reported the development of liposome - based vaccines and their efficacy and safety in preclinical mouse models for tauopathy.

Such models will allow for further understanding of critical genes and microRNAs involved in sarcoma development, progression and metastasis and can be utilized as preclinical models for therapeutic testing and efficacy.