Monitoring Healing Progression and Characterizing the Mechanical Environment
in Preclinical Models for Bone Tissue Engineering.
«Stem cell - based therapy for targeting skin - to - brain cancer: Stem cells loaded with oncolytic viruses show promising results
in preclinical models for targeting skin cancer metastases in the brain.»
Combining their strategy with an existing immunotherapy treatment that works by releasing the «brakes» on immune cells, they found they could shrink melanoma tumors, and prolong survival
in preclinical models for melanoma.
Not exact matches
Research
in recent years has covered both
preclinical basic research and the transfer of the results generated from studies of mouse
models to clinically applicable techniques
for treating female infertility.
The other study — Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents
in preclinical models of glioblastoma — published March 30, shows how drugs targeting PI3K and MAPK could represent promising candidates
for glioblastoma therapy.
In a study of
preclinical models of colorectal cancer, the researchers identified an underlying mechanism
for the activation of p53 by FL118.
«The
model for preclinical studies to predict with great accuracy which drugs would work
in the clinic was developed a decade ago,» says Dr. Chesi.
Long - awaited breakthroughs
in developing
preclinical animal
models are signaling a new era
for liver - targeted viruses and beyond
Overall, this work illustrates that better understanding the basic biology of the immune system
in preclinical models may open up a window
for the development of novel treatments
for human autoimmune disease.
«Novel imaging
model helps reveal new therapeutic target
for pancreatic cancer: Antisense treatment
in preclinical models shows effectiveness against deadly tumors.»
«This study
for the first time shows increased expression of IL - 33
in AMD and further demonstrates a role
for glia - derived IL - 33
in the accumulation of myeloid cells
in the outer retina, loss of photoreceptors, and functional impairment of the retina
in preclinical models of retina stress,» the authors note.
Our finding of similarity
in clinical progression between human patients and Huntington's disease monkeys suggests monkeys could become a
preclinical, large animal
model for the development of new treatments.»
Katherine W. Klinger, PhD, Senior Vice President
for Genetics and Genomics at the Genzyme Corporation, and Assistant Clinical Professor
in the Department of Pediatrics at the University of Connecticut School of Medicine suggested that
for an orphan disease it may be necessary to use multiple animal
models in the
preclinical research stage, because one animal
model may not fully recapitulate the human disease.
W. Bogers: PhD
in immunology and 20 years of experience with NHP
models for the
preclinical evaluation of HIV vaccine candidates as well as testing antivirals.
«The
preclinical results
in our animal
models are really exciting and have provided the momentum
for me to continue on this project, even after Novartis indicated that it no longer wished to maintain this collaboration.»
Together, this translational program is developed within the National Cancer and Cognition Platform (CNO / Ligue Nationale contre le cancer), with the aim to collaborate
in a structured way with French oncology groups, research teams as well as pharmaceutical industry, by providing
preclinical models and guidance on standard operating procedures
for ancillary or future studies
in identified population at risk.
EOS100850 is currently being evaluated
for safety and efficacy
in preclinical models.
In order to efficiently evaluate the newly designed vaccine candidates before testing them in clinical trials there is a need for development of reliable preclinical model
In order to efficiently evaluate the newly designed vaccine candidates before testing them
in clinical trials there is a need for development of reliable preclinical model
in clinical trials there is a need
for development of reliable
preclinical models.
This
model offers unique capabilities
for preclinical assessment of thrombosis risk
in a patient - specific manner, including efficacy testing of anti-thrombotic agents, elucidation of mechanism of action, and, potentially, biomarker identification, all providing a much - needed platform
for drug discovery and development.
The comprehensive information presented
for each cell therapy includes: an overview of the therapy, a list of therapeutic cells utilized
in the specific treatment, mode and regimen of cell delivery, mechanism of action, formulation,
in vitro data, animal
models,
preclinical data and related clinical trials.
Both recent experience with immunotherapy
for clearance of Aβ
in AD, and their own (and Prothena's) experience with AS - clearing immunotherapies
in animal
models, indicate that
in order to be effective as disease - modifying agents when administered alone, therapies that remove proteinaceous aggregates from the brain must be initiated
in the early clinical or even
preclinical stages of the disease, before the burden of other forms of aging damage becomes entrenched.
«Nutrient scavenging by autophagy is a process that tumors hijack to meet their energetic requirements and to provide the necessary cellular building blocks
for growth
in a stressed tumor micro-environment» said White, «
Preclinical models have demonstrated a critical role
for autophagy
in multiple cancer types.»
It is currently being evaluated
for safety and efficacy
in preclinical models with a Phase I trial expected to begin
in 2019.
The phenotyping platforms of PHENOMIN - ICS area, adapted to study genetically modified mouse
models, can also be used
for preclinical studies, including the validation of therapeutic targets, as well as pharmaceutical and toxicological studies
in mice.
AFF 1:
Preclinical Efficacy Data AFF 1 was then tested for preclinical efficacy in two models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a model with closer neuropathological and metabolic resemblance to L
Preclinical Efficacy Data AFF 1 was then tested
for preclinical efficacy in two models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a model with closer neuropathological and metabolic resemblance to L
preclinical efficacy
in two
models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a
model with closer neuropathological and metabolic resemblance to LBD than PD.
We have recently identified which cells are uniquely responsible
for the metastasis formation
in OSCC, and they exhibit the following characteristics: i) they are exclusive
in their ability to generate metastases; ii) they express the fatty acid translocase CD36, and express a unique lipid metabolic signature; iii) they directly link metastasis predisposition to dietary fat content; iv) they increase their metastatic initiation potency when treated with palmitic acid; v) they are highly sensitive to CD36 inhibition, which almost completely abolishes their metastatic potential
in preclinical models (Pascual et al., Nature 2016).
With our anti-TIGIT antibody program, we saw anti-tumor efficacy and reactivation of T - cells
in preclinical models which is encouraging
for the potential of this product as a monotherapy
Previously we reported the development of liposome - based vaccines and their efficacy and safety
in preclinical mouse
models for tauopathy.
Such
models will allow
for further understanding of critical genes and microRNAs involved
in sarcoma development, progression and metastasis and can be utilized as
preclinical models for therapeutic testing and efficacy.
Then,
in preclinical models of MYCN leukemia, the researchers tested a strategy of knocking out the gene
for the safety - valve protein.
and affinity of antibody ACI - 5400 were characterized by a panel of methods: (i) measuring the selectivity
for a specific phospho - Tau epitope known to be associated with tauopathy, (ii) performing a combination of peptide and protein binding assays, (iii) staining of brain sections from mouse
preclinical tauopathy
models and from human subjects representing six different tauopathies, and (iv) evaluating the selective binding to pathological epitopes on extracts from tauopathy brains
in non-denaturing sandwich assays.
The diverse group of experts has developed a biorepository of patient - derived tissues, which will be used
for testing investigational drugs
in preclinical models.
Now, three papers published concurrently
in Science have shown CRISPR can treat a genetic disease
in a postnatal mouse
model, an important proof of concept
for future
preclinical and clinical work.
Such
models will allow
for further understanding of critical genes and microRNAs involved
in sarcoma development, progression and metastasis and utilized as
preclinical models for therapeutic testing and efficacy.
His research group actively collaborates with several pharmaceutical companies to provide valuable
preclinical data
in animal
models for their targeted drugs.
The endocannabinoid system regulates energy homeostasis through G protein — coupled cannabinoid - 1 receptors5, 6 located
in the central nervous system and in various peripheral tissues, including adipose tissue, muscle, the gastrointestinal tract, and the liver.7 While peripheral cannabinoid - 1 receptor activation decreases adiponectin production in adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorder
in the central nervous system and
in various peripheral tissues, including adipose tissue, muscle, the gastrointestinal tract, and the liver.7 While peripheral cannabinoid - 1 receptor activation decreases adiponectin production in adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorder
in various peripheral tissues, including adipose tissue, muscle, the gastrointestinal tract, and the liver.7 While peripheral cannabinoid - 1 receptor activation decreases adiponectin production
in adipocytes, 8 central cannabinoid - 1 receptor activation in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorder
in adipocytes, 8 central cannabinoid - 1 receptor activation
in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorder
in preclinical studies stimulates eating, decreases muscle, and stimulates hepatic and adipose tissue lipogenic pathways
in animal models of obesity.9 In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorder
in animal
models of obesity.9
In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy for the treatment of obesity and related cardiometabolic disorder
In genetic and diet - induced obesity, rimonabant, a selective cannabinoid - 1 receptor blocker, reduces overactivation of the central8, 10 and peripheral11, 12 endocannabinoid system8, 10,13 and prevents weight gain and associated metabolic disorders, thus revealing a novel strategy
for the treatment of obesity and related cardiometabolic disorders.
Over 170 carefully curated, well - characterized patient - derived xenograft tumor
models are available
for use
in your facility, or use Horizon's comprehensive
preclinical in vivo efficacy service.
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Preclinical Drug Development, Drug Discovery,
In Vivo efficacy
models,
Preclinical R&D, ELISA, Cardiovascular, Cellular, Injections, Oncology, Research, Pharmaceutical, Business Development Manager, Cancer, Applications, Automation, Field Applications Scientist, Cell based assays