Sentences with phrase «in preclinical studies»

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

The lab used MRS in a preclinical study of SAPAP3 knockout mice — which model aspects of human obsessive compulsive and related disorders (OCRD)-- to determine whether these mice exhibit neurochemical abnormalities found in humans with OCRD.

NeuroPhage's NPT088 Universally Targets Misfolded Proteins in Preclinical Studies Highlighted in Oral Session at the Alzheimer's Association International Conference

NeuroPhage's NPT088 Universally Targets Misfolded Proteins in Preclinical Studies Highlighted in Oral Session at the Alzheimer's Association International Conference July 19, 2015

They have shown in a preclinical study that intrapleurally administered mesothelin - targeted CAR T cells were able to effectively eradicate mesothelioma and lung cancer with 30-fold greater efficacy than intravenously administered CAR cells.

We have developed a novel form of the naturally occurring growth factor gastrin, which in preclinical studies demonstrated its ability to significantly improve the survival of beta cells.

A missed milestone, particularly in preclinical studies, hardly signals a catastrophe, says Eric Schmidt, a biotech analyst at Cowen Group in New York City.

Most troubling, however, is the fact that every single late - phase clinical trial for Alzheimer's drugs — even those that held promise in preclinical studies — has failed.

SapC - DOPS (saposin - C dioleoylphosphatidylserine), is a nanovesicle drug that has shown activity in glioblastoma, pancreatic cancer and other solid tumors in preclinical studies.

The issue of sex is particularly acute in preclinical studies of Rett syndrome, a disorder caused by mutations in a gene located on the X chromosome.

«The next steps are to develop tau - lowering therapeutics that could be used in humans and to evaluate their safety and efficacy in preclinical studies,» said Dr. Mucke, «objectives we are pursuing actively.»

The researchers intend to make use of their new method in preclinical studies in the future and continue to develop it — for example, applying it to infections and to rheumatological and arthritic diseases.

In the preclinical study reported in Science Translational Medicine, 50 percent of mice treated with two doses of the vaccine — mice that would have otherwise died from melanoma within about 25 days — showed complete tumor regression.

An experimental drug has shown promise in treating influenza, preventing lung injury and death from the virus in preclinical studies, according to University of Maryland School of Medicine researchers publishing in the journal Nature on May 1.

No one is saying allow all animal experiments, but some are needed for fundamental research in preclinical studies that will ultimately translate into medical practice.

The researchers plan to intensively study the immune responses generated by therapeutic vaccines, broadly neutralizing antibodies, and latency reversing agents in both acutely infected individuals and also in preclinical studies.

It worked better in humans than it did in our preclinical studies where we made CAR T cells in mice with leukemia.

Previosly in a preclinical study BRAF inhibitor - resistant mutated BRAF melanoma cells were developed as an experimental model system to mimic BRAF inhibitor - resistant melanoma patients and to study the mechanisms of resistance.

The potential of Tumor Paint is not limited to brain tumors; it has been found in preclinical studies to light up prostate, colon, breast and other cancers.

Several ZIKV vaccine candidates using different platforms have shown promising results in preclinical studies.

MSCs have been widely tested in preclinical studies.

This announcement coincides with the presentation of data for SRK - 015 in preclinical studies, including a genetic model of SMA, being presented at the Cure SMA Annual Conference on June 29 - July 2, 2017 in Orlando, Florida.

Penn Medicine and CHOP researchers show that drug also maintains growth and limb motion in preclinical study of orphan disease

In this study, we clinically tested a therapeutic platform that we have previously described in preclinical studies [12] in which B cells from NHL dogs are expanded in vitro using CD40L transfected K562 cells (KtCD40L) and then loaded with autologous tumor RNA to generate a cell - based vaccine.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia, a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS One from the Perelman School of Medicine at the University of Pennsylvania.

DG041 is a novel, first - in - class, orally - administered small molecule which has been shown in preclinical studies to be a selective and potent antagonist of the EP3 receptor for prostaglandin E2 (PGE2), inhibiting human platelet aggregation in a dose - dependent manner.

In preclinical studies, oncolytic herpes simplex viruses seemed especially promising, as they naturally infect dividing brain cells.

«In preclinical studies, we've shown that when a MEK inhibitor was combined with an Akt inhibitor, which affects another cancer - related pathway, the results were better than when using MEK alone,» he said.

In preclinical studies, hypothermia and anti-oxidant treatment with N - acetylcysteine (NAC) are neuroprotective following neonatal hypoxic ischemia in females, but less so in males.

In a preclinical study, the scientists paired vagus nerve stimulation (VNS) with a physical therapy task aimed at improving the function of an upper limb in rodents.

In the preclinical study, WRAIR and the Beth Israel Deaconess Medical Center tested two Zika virus vaccine candidates: a DNA vaccine developed at Harvard based on a Zika virus strain isolated in Brazil, and a purified inactivated virus vaccine developed at WRAIR based on a Zika virus strain isolated in Puerto Rico.

In preclinical studies, Professor Stein and her colleagues are already testing new substances which inhibit both the expression and the activity of the MACC1 gene.

The US National Institutes of Health (NIH) will require grant applicants to report the gender of animals and cells used in preclinical studies, officials said today.

PHILADELPHIA — In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in

PHILADELPHIA — In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS One from the Perelman School of Medicine at the University of Pennsylvania.

In preclinical studies, the combination of epacadostat and immune checkpoint inhibitors was shown to be effective against cancer.

The UNC Lineberger researchers demonstrated in preclinical studies they could successfully design nanoparticles to capture mutated proteins released by tumors.