Sentences with phrase «in preclinical work»

Russell Kern, chief scientific officer of the International Stem Cell Corporation in Carlsbad, California, which is providing the cells for and managing the Australian trial, says that in preclinical work, 97 % of them became dopamine - releasing cells.

«She had worked at Immunex's law department, was one of the co-discoverers of Enbrel and was listed on multiple original Immunex patents, and had been involved in preclinical work on compound discovery,» says Ruth Kunath, who managed Vulcan's biotech portfolio from 1992 to 2003 and hired Beckmann.

«What we discovered in our preclinical work is evidence of how groups of neurons coordinate and cooperate with each other in a very particular way that gives us deeper insight into how the brain is controlling the arm,» Shenoy said.

Not exact matches

Laura holds degrees in Chemistry and currently works as a bioanalytical chemist in a preclinical pharmaceutical laboratory.

Worked in preclinical research for 12 years and now a Medical Assistant / Phlebotomist and chicken farmer.

Researchers believed that galeterone could be effective against CRPC because it disrupts the androgen receptor signalling pathways that are involved in the cancer, and preclinical work has shown it is active against the AR - V7 variant.

The scientists are now trying to identify antibodies that would be effective in humans, and a company has been formed to move the work towards translation and determine which models are most useful in a preclinical setting.

«Even though they're inactivating the virus, it's still there,» says Ross, whose laboratory worked with Novavax during its preclinical studies, when the start - up was in need of laboratory facilities.

«The new compounds would need to work effectively in mice and pass preclinical benchmarks before they can be tried in humans,» Zimmerman said.

In the University of Toronto MD / PhD Program, the majority of students complete the preclinical courses of medical school (i.e., the first year and a half) and then pursues full - time graduate work, completes the PhD, and only then returns to medical school to complete the clinical component.

«To better understand safety issues, we are making efforts to employ more modern investigational, molecular approaches to safety assessment — and increase our safety testing work force by about 10 percent,» says Phil Bentley, vice president and global head of preclinical safety at Novartis Institutes for BioMedical Research in New York City.

Combining their strategy with an existing immunotherapy treatment that works by releasing the «brakes» on immune cells, they found they could shrink melanoma tumors, and prolong survival in preclinical models for melanoma.

But in preclinical research — work with animals and cells — the preference for males has remained steadfast.

«The model for preclinical studies to predict with great accuracy which drugs would work in the clinic was developed a decade ago,» says Dr. Chesi.

The group plans to continue exploring the mechanics of SF3B1 while also pushing forward with the preclinical work needed to form the rational basis for targeting this gene in patients with advanced mucosal melanoma.

Overall, this work illustrates that better understanding the basic biology of the immune system in preclinical models may open up a window for the development of novel treatments for human autoimmune disease.

The study, which lays the foundation for future preclinical work, appears June 14 in Stem Cell Reports, a publication of the International Society for Stem Cell Researchers.

If you had to pick an area of the brain that you can fix, the memory area is the most obvious because motor - task memory is really pretty well - worked out in preclinical models.

Hua's extensive work in Krainer's lab, in collaboration with Ionis, led to the identification and preclinical development of nusinersen, a snippet of modified RNA called an antisense oligonucleotide that intervenes in the splicing process to ensure that SMN2 expresses the full - length SMN protein.

Janssen GPH will also prioritise work with the International Partnership for Microbicides developing the investigational drug dapivirine for use as a monthly vaginal microbicidal ring designed to prevent sexual transmission of HIV and continue its pact with Drugs for Neglected Diseases initiative for the preclinical research of a reformulated form of flubendazole for lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), Janssen GPH is also developing a new, chewable formulation of Vermox (mebendazole) that will facilitate treatment of intestinal worms in younger children.

And there are a lot of treatments, or let's say potential treatments, that are working wonderfully in preclinical models that are ready to make the leap to human testing, and some of these have begun to make that transition to bridge from the laboratory to human - patient testing.

A major asset of the OMC platform is the tight integration of preclinical scientists with physicians, who work side by side to comparatively assess pathogenic, diagnostic and therapeutic issues raised in patients with the mouse model counterpart.

Faulty mitochondria contribute to a range of diseases and a research group working towards the use of mitochondrial donation techniques for women at risk of passing on those diseases to their children have described their preclinical work in the journal Nature.

Our group is specifically working on improvement of islet isolation and transplantation protocols in clinical practice and the development of novel therapeutic options in the field of beta cell replacement with a clear translational «bench to bedside» approach by linking experimental research with preclinical and clinical work:

But while substantial data (including AFFiRiS» [15] and Prothena's [20,22] preclinical work) give good reason to think that early clearance of AS neuropathology will decelerate the rate of SN DA neuronal loss, astrocytosis, and possibly accumulation of senescent glial cells in PD, there is no reason to think that doing so will prevent these phenomena entirely, if for no other reason than because many other factors also contribute to their occurrence.

«The preclinical work being done by the McDonald lab has been extremely informative in helping us understand that Pexa - Vec is working like a vaccine to sensitize the immune system to attack cancer,» said James Burke, CMO of SillaJen Biotherapeutics.

Jörg has a proven ability of managing small companies, directing preclinical drug research and discovery, external collaborations and working in multinational environments in the biotech and pharmaceutical industry.

Our researcher received a proof - of - concept grant from the Washington Life Sciences Discovery Fund, and worked with Washington State University and Malignext to conduct preclinical trials that produced results that will be helpful in future preclinical and clinical trials.

His work has led to the development of two potential malaria vaccines, one of which is in clinical trials in the US and the other in preclinical development.

This preclinical work led to the development of a novel anti-androgen ARN - 509, a small - molecule inhibitor discovered in collaboration with UCLA chemist Michael Jung, which targets the increased levels of androgen receptor found in hormone - refractory disease.

Now, three papers published concurrently in Science have shown CRISPR can treat a genetic disease in a postnatal mouse model, an important proof of concept for future preclinical and clinical work.

In parallel, we are going to finish the preclinical work for our modular mono - or multispecific targeting systems.

Dr. Lui has seven years of experience working in preclinical drug development and target validation in academia and industry.

At Sanofi I worked in a preclinical group, working with a team to develop a novel mouse model.

The past century has unveiled a plethora of preclinical data that has suggested the potential of a ketogenic diet as an aid in cancer treatment.7, 8 The benefits of a ketogenic diet, and dietary manipulation in general, may be a potent adjunct to current cancer treatments by synergistically working with chemotherapy and radiation therapy to starve cancer cells, leaving them more susceptible to damage from these treatments.7 - 10

Best Friends Animal Society headquartered in Kanab, Utah, and Pets Alive Animal Sanctuary, based in Middletown, N.Y., and Elmsford, N.Y., worked together on rescuing the beagles, who had been left locked in the facility operated by Aniclin Preclinical Services in Warren County, N.J.

AGTC plans to use the net proceeds of the offering to fund preclinical investigation and Phase 1/2 trials of potential product candidates for treatment of wet AMD; to expand its manufacturing capabilities and create a pilot manufacturing group; to in - license, acquire or invest in complementary gene therapy, technologies, products or assets; and for working capital and other general corporate purposes.

About Blog Helps you in every step of your research: publication of your work, preclinical development, preparation of regulatory documents.

Work experiences listed on sample resumes of Planning Managers include skills like providing recommendations regarding market potential for new targets including, but not limited to, indication prioritization and fast - to - market strategies, and providing commercial analysis in order to gain partnering opportunities for preclinical stage compounds.

My objective to restart working in preclinical pharmaceutical clinical pathology laboratory; however, I would consider working as GLP QA entry position.