Sentences with phrase «in proliferative»

The strict limit in proliferative potential of normal human somatic cells - a process known as replicative senescence - is highly relevant to the immune system, because clonal expansion is fundamental to adaptive immunity.

Essential role for Survivin in the proliferative expansion of progenitor and mature B cells.

Future studies can now address how to maintain induced retinal cell cultures in a proliferative, multipotent state and drive them to all the retinal cell classes necessary to repair a damaged or degenerating mature retina.

A potential cause underlying this difference in the proliferative capacity of basal progenitors could be the differential expression of Pax6 between species.

Not exact matches

Comment - Spirits - Keeping an Eye on the Little Guys In the whisky category, it would appear that, while the big are getting bigger, the small are getting... more proliferative.

In this research, the group looked at two variants of miR - 21, a microRNA «oncomiR» known to target tumor suppressor genes and which is highly expressed in a number of cancers as well as other proliferative diseases such as psoriasiIn this research, the group looked at two variants of miR - 21, a microRNA «oncomiR» known to target tumor suppressor genes and which is highly expressed in a number of cancers as well as other proliferative diseases such as psoriasiin a number of cancers as well as other proliferative diseases such as psoriasis.

«This in - depth characterization of individual beta cells in different proliferative states was enabled by newer technology.

In contrast, basal progenitors in mice and manatees lack this proliferative capacity and thus produce less neurons and less folded or unfolded brainIn contrast, basal progenitors in mice and manatees lack this proliferative capacity and thus produce less neurons and less folded or unfolded brainin mice and manatees lack this proliferative capacity and thus produce less neurons and less folded or unfolded brains.

This is so because basal progenitors capable of symmetric proliferative divisions are present in the neurogenic program of these animals.

I am a medical doctor, a specialist in ophthalmology, and for my PhD research at the Medical University in Sofia I have been looking at the ultrastructural changes of the proliferative tissues in the eyes of diabetics.

This particular technology is designed for cultivating tissues (retinas, proliferative tissue, corneas, etc.) in conditions which resemble to the highest possible degree the conditions found in the human body.

Interestingly, this state appears to differ from that of quiescent fibroblasts in the uninjured heart, as it is resistant to proliferative stimuli.

Abadir and colleagues first tested 5 percent topical losartan on mice in three different phases of wound healing: group 1 treatment, for up to three days post-wound infliction to target the inflammatory phase; group 2 treatment, starting on day seven after wound infliction to target the proliferative / remodeling (later) phase of tissue healing; and group 3 treatment, starting the first day of wound infliction until closure to treat all wound healing phases.

Cell cycle protein expression and proliferative status in human corneal cells.

A microRNA network regulates proliferative timing and extracellular matrix synthesis during cellular quiescence in fibroblasts.

Wilson et al. [3,4] were able to impart proliferative ability in HCECs by transfection with simian virus 40 (SV40) large T antigen [3] and E6 / E7 human papilloma virus type - 16 oncogenes [4].

P2Y1 and P2Y13 purinergic receptors mediate Ca2 + signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells.

Evidence from these studies indicates that the use of mismatched MSC does not provoke a proliferative T cell response in allogeneic MLR, thus suggesting an immunosuppressive role for MSC 83, 84, 85, 86, 87, 88.

Consistent with these studies, Bartholomew et al 92 showed that allogeneic baboon MSC suppressed the proliferative activity of lymphocytes in vitro and prolonged graft survival.

«When TET proteins are lost, iNKT cells that lack them apparently become trapped in an immature, highly proliferative state,» explains Tsagaratou.

But if, as this study suggests, the way that cells become proliferative again is similar across many different organs, we can imagine therapies that interfere with cancer initiation in a more global way, regardless of where that cancer may appear in the body,» he explains.

The first Phase 1 study of this vaccine in a malaria - exposed population found it to have promising safety and tolerability profiles in adults in Bandiagara, Mali, and to elicit dose - dependent anti-AMA1 antibody responses [17] as well as IL - 5 production and lymphocyte proliferative responses [22].

Cancer cells are highly proliferative compared to the majority of cells in the human body.

«The best case scenario is that from this one very accessible and highly proliferative source of stem cells, we will be able to obtain multiple different cell types that can be used for a broad range of applications in regenerative medicine,» he said.

Willet, Mills, and their colleagues believe the discovery that cells in different organs go through the same process to become proliferative could lead to new potential targets for cancer treatment because the factors that initiate tumours could be the same in multiple organs.

The mission of the partnership is to advance knowledge in the field of proliferative and degenerative diseases through fundamental and applied biology research.

Retraction: The Epstein - Barr Virus - encoded miR - BART22 targets MAP3K5 to promote host cell proliferative and invasive abilities in nasopharyngeal carcinoma Ruichao Chen, Minfeng Zhang, Qiulian Li, Hanzhen Xiong, Shaoyan Liu, Weiyi Fang, Qianbing Zhang, Zhen Liu, Xuehu Xu, Qingping Jiang Journal of Cancer 2017; 8:3130 - 3130

Lange SS, Bedford E, Reh S, Wittschieben JP, Carbajal S, Kusewitt DF, DiGiovanni J, Wood RD (2013) Dual role for mammalian DNA polymerase zeta in maintaining genome stability and proliferative responses.

(ii) In addition, we have uncovered the first link between pathways that signal DNA damage and mediate DNA - repair and hypoxia - induced neovascularisation in the course of proliferative retinopathieIn addition, we have uncovered the first link between pathways that signal DNA damage and mediate DNA - repair and hypoxia - induced neovascularisation in the course of proliferative retinopathiein the course of proliferative retinopathies.

It has long been known that heart muscle cells (cardiomyocytes) actively divide and expand in the embryo, but after birth this proliferative capacity is permanently lost.

In addition, well - characterized expression profiles for melanoma cells have been identified that correlate highly proliferative cell states with increased expression for pathways regulated by the lineage - specific transcription factors SOX10 and MITF; conversely, migratory / invasive cell states have been correlated with TGFβ1 signaling pathways.

A collaboration with the Roche pharmaceutical company led to the screening of 200 000 Roche compounds on human neural stem cells in order to identify proliferative drugs.

A number of recent articles, however, have reported that hiPSCs are, in fact, notably distinct from human embryonic stem cells in terms of their gene expression, epigenetic profile, proliferative capacity and the susceptibility of their differentiated progeny to cellular senescence and apoptosis [3 — 6].

It has been shown in imatinib - resistant CML that drug resistance conferred by mutations does not necessarily correlate with proliferative advantage and increased kinase activity.34 Other, non-activating mutations or drug - resistance mechanisms, might be acquired by tumor cells.

In the other major form of diabetic eye disease, proliferative diabetic retinopathy, blood vessels grow in wrong places on the retinIn the other major form of diabetic eye disease, proliferative diabetic retinopathy, blood vessels grow in wrong places on the retinin wrong places on the retina.

The lower level of endodermal contribution we observe in chimeras suggests that even in the PrEn, V+S + ES cells may be at a proliferative disadvantage.

Modeling of PRDM16haploinsufficiency and a human truncation mutant in zebrafish resulted in both contractile dysfunction and partial uncoupling of cardiomyocytes, and also revealed evidence of impaired cardiomyocyte proliferative capacity.

Aging in humans is associated with increased infections and the reduced proliferative capacity of T cells, part of the more global phenomenon termed immune senescence.

In a commentary in the journal, Moss, Singleton and Frances Lennon, PhD, summarize results from multiple studies to argue that opioids — drugs like morphine or the body's own opioids, such as endorphins — appear to have a significant and direct proliferative effect on cancer cells, aside from their effect suppressing immunitIn a commentary in the journal, Moss, Singleton and Frances Lennon, PhD, summarize results from multiple studies to argue that opioids — drugs like morphine or the body's own opioids, such as endorphins — appear to have a significant and direct proliferative effect on cancer cells, aside from their effect suppressing immunitin the journal, Moss, Singleton and Frances Lennon, PhD, summarize results from multiple studies to argue that opioids — drugs like morphine or the body's own opioids, such as endorphins — appear to have a significant and direct proliferative effect on cancer cells, aside from their effect suppressing immunity.

Aged human SkMs show a decline in the number and proliferative potential of the SCs.

Presented in the journal PLoS ONE, the study ′ s findings shed light on the motility of myxozoa ′ s proliferative states and their reproductive process.

Parsa R, Yang A, McKeon F, Green H. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes.

In contrast, previous studies have shown that Oct4 mRNA levels can remain relatively stable during DMSO - induced differentiation of P19 cells, although this has been ascribed to undifferentiated, highly proliferative cells present in the cultures following differentiation [22], [34In contrast, previous studies have shown that Oct4 mRNA levels can remain relatively stable during DMSO - induced differentiation of P19 cells, although this has been ascribed to undifferentiated, highly proliferative cells present in the cultures following differentiation [22], [34in the cultures following differentiation [22], [34].

Their subsequent work (3) in clonal cultures revealed three distinct types of clones with profoundly different proliferative capacity.

GLD -4-mediated translational activation regulates the size of the proliferative germ cell pool in the adult C. elegans germ line.

Determination of glutathione in lymphocytes and possible association of redox state and proliferative capacity of lymphocytes.

Estrogens are known for their proliferative effects on estrogen - sensitive tissues resulting in tumorigenesis.

In mice, the administration of taurine prevented the decline in T - cell number that occurs with aging and enhanced the proliferative responses of T - cells in both young and old micIn mice, the administration of taurine prevented the decline in T - cell number that occurs with aging and enhanced the proliferative responses of T - cells in both young and old micin T - cell number that occurs with aging and enhanced the proliferative responses of T - cells in both young and old micin both young and old mice.

«In summary, [their] study observed significant inverse associations between adolescent dietary intake of fiber and nuts and risk of proliferative benign breast disease.

Diindolylmethane, or DIMÂ ® has been shown to help regulate and promote a more efficient metabolism of estrogen, by supporting the body in metabolizing estrogen into more of the protective 2 - hydroxyesterone rather than the proliferative 16 - hydroxyesterone.