According to the study, genetics and lifestyle together account in some cases for more than 50 per cent of
variations in protein levels among healthy individuals.
This conclusion differs dramatically from the previous estimates of differences in mRNA levels explaining 10 - 40 % of the
differences in protein levels in the current literature.
That is why we aimed to map some of the «normal» variation
in protein levels in our study,» says Robin Myte.
Incorporating protein and mRNA turnover data in this analysis, the results from Li et al. suggest that mRNA levels explain ~ 81 % of the
variance in protein levels, transcription 71 %, RNA degradation 10 %; translation 11 %; and protein degradation 8 %.
Protein profiles in the Dp (10) 1Yey and Dp (17) 1Yey mice predict novel pathway perturbations in the Down syndrome brain and sex - specific abnormalities in protein levels
They found that sleeping mice, compared to awake mice, had a 20 percent
drop in protein levels that indicate the weakened synapses typical of the scale - down process.
Biomarkers used for diagnosing disease should preferably indicate variations
in protein levels only for those individuals who are suffering from a particular disease.
He graduated in 2011 and moved to Boston, where he spent 2 years as a postdoc in the lab of Hanno Steen learning mass spectrometry and studying
changes in protein levels during Xenopus embryo development.
Not all proteins in puppy food are created
equally in protein level, so Merrick takes the guess work out of this important factor in selecting a dog food.
«Instead of associating a mutation with a disease, our system will learn that this mutation is creating a problem because it's causing a decrease
in the protein level, and that decrease in the protein level can lead to this disease, and that's very valuable for the diagnostician,» explains Frey.
Since the introduction of large - scale mRNA and protein measurements in the late 1990s, most studies have concluded that differences in mRNA levels explained around 40 percent of the differences
in protein levels.
The low correlation suggested that some process acting after mRNA transcription — broadly called post-transcriptional regulation — accounted for the difference
in protein levels.