Do you want the top rheumatologist in the country who specializes
in psoriatic arthritis, or are you ok with a rheumatologist who treats a variety of conditions?
As of early this year, they're competing
in psoriatic arthritis, too — and each drugmaker made its case this week with new data in that disease.
But Novartis, Celgene, and Pfizer are now duking
it in the psoriatic arthritis space, unveiling positive clinical trial data for inflammatory drugs Cosentyx, Otezla, and Xeljanz (respectively) during the American College of Rheumatology's (ACR) annual meeting.
Three biopharma giants jockey for market share
in psoriatic arthritis with new data.
Not exact matches
The play for
psoriatic arthritis indications makes sense because it would add some depth to the companies» market penetration
in the psoriasis - related disease space, which already has plenty of available options.
The company blamed slowing growth
in both the psoriasis and
psoriatic arthritis markets
in the U.S. due to reimbursement challenges from insurers.
One drugmaker is skipping the crowded psoriasis track altogether and going straight to
psoriatic arthritis: Pfizer, whose Xeljanz also came up big
in studies presented at ACR.
Novartis this week presented data showing that patients on Cosentyx achieved long - term improvements
in the signs and symptoms of
psoriatic arthritis.
Meanwhile,
in the private sector, Japan has also become the first nation to approve commercialization of a first - line drug for psoriasis vulgaris and
psoriatic arthritis from the Swiss pharmaceutical company Novartis.
«For many years, the rheumatology and dermatology communities have been trying to understand which patients with psoriasis go on to develop
psoriatic arthritis and how we might detect it earlier
in the disease course,» explained senior investigator Cheryl Barnabe, MD, MSc, of the McCaig Institute for Bone and Joint Health and the O'Brien Institute for Public Health, Cumming School of Medicine, at the University of Calgary, Alberta, Canada.
«The Food and Drug Administration (FDA) has announced the approval of Inflectra (infliximab - dyyb), the first biosimilar to receive approval
in the U.S. for the treatment of rheumatic diseases, including rheumatoid
arthritis and
psoriatic arthritis.
Guselkumab, a fully human monoclonal antibody targeting IL - 23,
in this Phase 2 study for the treatment of PsA, was well tolerated with no unexpected safety findings
in this patient population.2 Guselkumab is now being pursued
in a Phase 3 development programme for
psoriatic arthritis.
Researchers led by the
Arthritis Research UK Centre for Genetics and Genomics at The University of Manchester have identified genetic variants that are associated with psoriatic arthritis (PsA) but not with psoriasis, in the largest study of PsA ever p
Arthritis Research UK Centre for Genetics and Genomics at The University of Manchester have identified genetic variants that are associated with
psoriatic arthritis (PsA) but not with psoriasis, in the largest study of PsA ever p
arthritis (PsA) but not with psoriasis,
in the largest study of PsA ever published.
The findings could,
in future, lead to the identification of people with psoriasis who are at risk of developing
psoriatic arthritis.
«Although anti-TNF treatments have revolutionised the management of
psoriatic arthritis, new next - generation therapies are needed
in the treatment of this disease,» he added.
Until recently opinion was divided as to whether
psoriatic arthritis was a disease
in its own right, or psoriasis combined with rheumatoid
arthritis.
In a recent study of almost 1,500
psoriatic arthritis sufferers, smokers didn't respond to medication as well as non-smokers and they didn't stick with treatment very long.
Turmeric, a spice used liberally
in Indian cuisine, has both anti-inflammatory and antioxidant effects that may help control flares
in both psoriasis and
psoriatic arthritis, according to the National Psoriasis Foundation.
Mornings are especially hard if you have
psoriatic arthritis, as you may wake up stiff and
in pain, says Dr. McKown.
Taming the beast «I describe psoriasis to my patients as a wild animal
in a room — and the room is their life,» says dermatologist Andrew Blauvelt, MD, who sees a variety of complex cases as the research director of the Center of Excellence for Psoriasis and
Psoriatic Arthritis at Oregon Health & Science University
in Portland.
Like
psoriatic arthritis, debilitating pain and stiffness from inflammation usually occur
in the morning or after resting, but symptoms can also last all day.
It's not clear which comes first — the weight or the disease — but extra weight stresses your joints, and ups your risk for heart disease, diabetes, and metabolic disorder (all of which are already a risk
in people with
psoriatic arthritis).
In the case of rheumatoid arthritis and psoriatic arthritis, for example, «control [ling] inflammation is the goal of treatment,» says Dr. Askanase, although she notes that other pain management methods are usually used in addition to therapies aimed at controlling inflammation, such as non-steroidal anti-inflammatory drugs (NSAIDs
In the case of rheumatoid
arthritis and
psoriatic arthritis, for example, «control [ling] inflammation is the goal of treatment,» says Dr. Askanase, although she notes that other pain management methods are usually used
in addition to therapies aimed at controlling inflammation, such as non-steroidal anti-inflammatory drugs (NSAIDs
in addition to therapies aimed at controlling inflammation, such as non-steroidal anti-inflammatory drugs (NSAIDs).
Curious about other things you should avoid
in order to keep your
psoriatic arthritis symptoms
in check?
In an effort to get the word out about how people in pain can get assistance, Goen rode his motorcycle across the lower 48 states talking about his psoriatic arthriti
In an effort to get the word out about how people
in pain can get assistance, Goen rode his motorcycle across the lower 48 states talking about his psoriatic arthriti
in pain can get assistance, Goen rode his motorcycle across the lower 48 states talking about his
psoriatic arthritis.
Uveitis, a painful inflammation of the eye, is more common
in people with
psoriatic arthritis.
These drugs have been approved for use
in treating some or all types of psoriasis or
in some cases, just
psoriatic arthritis, a type of
arthritis that occurs
in 6 % to 40 % of people with psoriasis.
Researchers have noted vitamin D deficiencies are more common
in people with
psoriatic arthritis than the rest of the population.
The warmth really seems to soothe my sore joints — I do not know how my friends with
psoriatic arthritis who live
in New York and northern climates do it!
In a matter of weeks, I went from essentially spending three years on the couch to traveling 14,600 miles across the country on my Harley Ultra Classic, all because of my
psoriatic arthritis.
For some patients, certain triggers may cause
psoriatic arthritis symptoms to flare up — stress, cold or damp weather, and quick weather changes
in general are big ones for Quinn.
John Montemarano, a 55 - year - old retired director for the New York City public transportation system, put the pieces together that he might have
psoriatic arthritis after being diagnosed with mild psoriasis
in his mid-40s.
Up to 30 % of psoriasis patients will eventually develop
psoriatic arthritis, which causes pain, swelling, and stiffness
in the joints.
Both psoriasis and
psoriatic arthritis are autoimmune diseases, meaning the immune system attacks parts of the body (
in the case of
psoriatic arthritis, the joints).
People with
psoriatic arthritis often experience pain, swelling, and stiffness
in their joints and tendons, as well as fatigue, eye irritation, changes to the skin and nails, and reduced range of motion.
For Sarah Truman, a 40 - year - old manager of a corporate payroll department who was diagnosed with
psoriatic arthritis in 2010, staying healthy is a constant battle, especially because she takes public transportation to work everyday.
Although
psoriatic arthritis patients usually develop the disease
in their 20s or between 50 and 60, children can have it as well, says Dr. Lebwohl.
«Many of these supplements or vitamins may ease some of the symptoms of
psoriatic arthritis, but none have been shown to prevent damage,» says Guy Fiocco, MD, assistant professor of internal medicine at Texas A&M Health Science Center College of Medicine,
in Bryan.
In 2003, I also decided to start a support group in Pittsburgh, because I had never met anyone else who had psoriatic arthriti
In 2003, I also decided to start a support group
in Pittsburgh, because I had never met anyone else who had psoriatic arthriti
in Pittsburgh, because I had never met anyone else who had
psoriatic arthritis.
Clinics that offer a broader, team - based approach to treating psoriasis are also beginning to emerge, says dermatologist Andrew Blauvelt, MD, a professor at Oregon Health & Science University
in Portland and the research director of the universitys Center of Excellence for Psoriasis and
Psoriatic Arthritis, which combines the efforts of dermatologists, rheumatologists, and psychiatrists.
In the midst of intense pain, hospitalization, and joint replacement surgery, she felt isolated and alone; she had never met anyone else with
psoriatic arthritis.
I have
Psoriatic Arthritis and am taking immune suppressing medications and to make a long story short due to some rounds of antibiotics ended up with thrush
in my mouth and esophagus, also yeast on my skin.
Psoriatic arthritis is an autoimmune disease, which means the body's immune system turns on itself,
in this case leading to inflammation of the joints.
And because extra pounds put added pressure on joints — potentially worsening
psoriatic arthritis symptoms and leading to deterioration of the joints over time — patients should make it a goal to maintain a healthy weight, says Marie Jhin, MD, a board - certified dermatologist
in the Bay Area who cares for patients with disease.
In other words, limiting your sugar intake is a smart strategy for everyone, but it's especially important for those with
psoriatic arthritis.
And although
psoriatic arthritis can occur
in childhood, most people are first diagnosed when they are between 30 and 50 years old.
More than 7 million people
in the United States have psoriasis, and 30 % of them may eventually develop
psoriatic arthritis.
Those who were obese
in their teens may also have a greater risk of developing
psoriatic arthritis later.
«You want more foods that have been shown to be high
in antioxidants [if you have
psoriatic arthritis],» says Dr. Jhin.
Although
psoriatic arthritis can affect any joint
in your body, it's often
in the fingers and toes, the ankles, knees, wrists, lower back, or spine.