Sentences with phrase «in regulating cell growth»

mTOR is a biological pathway in the body which plays an important role in regulating cell growth and proliferation that may also have an influence over cancer growth (6).

Vitamin D - 3 also plays an important role in regulating cell growth, insulin levels, and bone formation.

In preclinical experiments using human prostate cancer cell lines, Fu's team showed that increased PLK1 expression activated an oncogene known as c - RAF, which has previously been shown to play a role in regulating cell growth and division.

Not exact matches

Eicosonoids from Omega - 3's are hormone - like compounds that help regulate blood pressure, blood clotting, aid in growth and development of cells, needed for vision and brain development, and maturation of nerves.

Hydrolyzed Collagen is the missing link in supplying amino acids like glycine, proline and lysine that are required by the body to build connective tissue to regulate cell growth.

To get more cells, researchers from Advanced Cell Technology in Worcester, Mass., grew clusters of human embryonic cells in a precise cocktail of growth factors and other cell - regulating chemicals that took several years to work out, says Robert Lanza, the firm's vice president of research and scientific developmCell Technology in Worcester, Mass., grew clusters of human embryonic cells in a precise cocktail of growth factors and other cell - regulating chemicals that took several years to work out, says Robert Lanza, the firm's vice president of research and scientific developmcell - regulating chemicals that took several years to work out, says Robert Lanza, the firm's vice president of research and scientific development.

They cross the blood - brain / blood - tumor barrier, and accumulate within brain tumor sites, where they target oncogenes, regulate cell growth and differentiation, reduce tumor burden and prolong survival in our mouse models.»

«CRKII most likely regulates the stability of mutated epidermal growth factor receptors and drives cancer growth by promoting signaling, or communication, within cancer cells,» said Julia Petschnigg, lead author on the paper and a postdoctoral fellow at U of T. «We found that a combinatorial chemotherapy that inhibits those mutated receptors and CRKII could be beneficial in treating lung cancer.»

In cancer, these switches inappropriately activate or silence important genes, such as those that regulate cell growth and life cycle, ultimately leading to tumors.

In this study, the scientists have examined how Dpp regulates growth and analysed how cells behave when Dpp levels are manipulated.

These play a key role in controlling gene expression and, thereby help regulate the cell's development, growth and function.

The publication, «Androgens Regulate Prostate Cancer Cell Growth via an AMPK - PGC - 1α - Mediated Metabolic Switch,» featured online in Oncogene, illuminates a known metabolic pathway as a potential novel therapeutic target.

About ten years ago, research results showed that things are not quite as simple as that: «Under most conditions, H2O2 is not an undesired side product but rather an essential chemical messenger that plays an important role in regulating the way in which body cells respond to signals from outside such as hormones and growth factors,» says Dr. Tobias Dick of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ).

According to Beg, NF - κB proteins regulate key genes involved in immune response, inflammation, cell death and cell growth.

Still, by identifying the human hairless gene as an important master switch in regulating cell death in a hair follicle — a discovery that could lead to gene therapies for unwanted hair growth — Christiano emerged as a new star in the field, and a glamorous one.

Dr. Doug Zochodne and his team have discovered a key molecule that directly regulates nerve cell growth in the damaged nervous system.

AMPK responds to energy deficits in the cell by down - regulating energy consuming processes, which are often associated with cell growth, and up - regulating energy producing processes.

Research from Rutgers Cancer Institute of New Jersey shows that the RUNX2 protein, which regulates the transcription of genetic messages responsible for the different functions of cells, may play a role in melanoma cell growth and spread and could serve as a therapeutic target for the disease.

Her work described the regulatory link between the metabolic enzyme ATP - citrate lyase and histone acetylation levels in mammalian cells, and established that glucose utilization in the hexosamine biosynthetic pathway regulates growth factor receptor signaling.

IGFBP3, a direct KDM6A / EZH2 / H3K27me3 target, was up - regulated by EZH2 inhibition and contributed to the observed EZH2 - dependent growth suppression in KDM6A - null cell lines.

She notes that stem cells normally divide and reproduce in a very regulated way, «but these signals get hijacked during cancer formation and may promote cancer growth.»

By performing experiments in petri dishes and with mice, they found that panobinostat, a drug designed to change the way cells regulate genes, may be effective at inhibiting DIPG growth and extending survival rates.

His lab studies a particular signaling pathway, the RAS / RAF / MEK / ERK pathway, which regulates cell growth and survival in several cancers.

The inhibition is regulated by different molecules in animals and plants,» explains NAIST Professor Masaaki Umeda, who studies the role of stem cells in plant growth.

Apart from advancing our understanding of how plants regulate their growth and shape, this research presents new questions for stem cell researchers in regards to cell size checkpoints and their importance during organism development.

In particular, his laboratory focuses on the regulation of key signaling networks that regulate cancer cell growth and survival.

It is well known that ribosome biogenesis is a key component of the cell cycle as it regulates cell size and growth and the IBS team has uncovered that SSUPs play a critical role in maintaining induced pluripotent stem cell integrity.

P53 is a tumor suppressor gene, a protein that regulates cell growth, and it is the most frequently mutated suppressor gene in cancer.

How cells regulate their size and how cell size affects organism growth are among the remaining mysteries in cell biology.

The protein mTOR helps monitor nutrient levels in cells and regulates cell movement, protein production, and cell growth and survival.

Jasper says researchers at the Buck are also testing homologues of rapamycin that are more specifically aimed at TOR Complex 1 — a key complex containing TOR that regulates cell growth and metabolism in all complex organisms.

Several anti-cancer drugs attempt to halt the growth of tumors by blocking mTOR, a key part of a growth - regulating network that is often disrupted in cancer cells.

The protein mTOR regulates cell growth and metabolism and thus plays a key role in the development of human disorders.

Several drugs, some used clinically today, have been found to be effective in regulating the growth of neural stem cells, including cancer cells

Proteasomes play an important role in the degradation of proteins that regulate the cell cycle, thereby regulating cell growth.

The ROBO family of signaling proteins — best known for their role in guiding the growth of developing neurons — regulates the cytoskeleton, and may therefore help cells sense and respond to such changes in their environment.

One of the key metabolic alterations that takes place during EMT is that of the epidermal growth factor receptor (EGFR) which is a pathway that regulates growth, survival, proliferation, and differentiation in mammalian cells.

Subsequent tests revealed that the retrovirus used to ferry the corrective gene into the DNA of blood - making cells in the bone marrow had lodged in or near a gene that regulates T cells, possibly prompting their uncontrolled growth.

University of California, Berkeley researchers have now found a promising new drug target within that pathway that is appealing, in part, because it appears to control production of only a few percent of the body's many proteins, those critical to regulating the growth and proliferation of cells.

They found that BET proteins regulate the growth of heart muscle cells and activate a broad set of genes involved in heart failure.

Previously described as the «guardian of the genome» and voted «Molecule of the Year» in 1993, p53 is one of the most important proteins regulating cell growth and a major focus for oncology research.

Integrins bind to protein scaffolds in their environment and regulate pretty much everything a cell does — movement, change and growth.

Their findings provide new insights into how the protein regulates cell growth and how mutations in the gene that encodes the protein can lead to cancer.

Normally, MIR506 plays an important role in regulating cell behavior; adequate levels help the cells function normally, while decreased levels trigger cell growth and expansion occurring in tumors.

The subpopulation that failed to produce Wnt1 contributed to tumor growth with a mutation in a gene called HRas, which regulates cell division.

mTOR - raptor complex is sensitive to rapamycin and regulates cell growth, in part, by phosphorylation of p70S6K and subsequently rpS6 and 4E - BP1, thus promoting protein translation.

Binding of JSRV sheep lung cells might interfere with the receptor's normal role in regulating cell proliferation, causing unregulated growth.

Title: Notch Signaling Regulates Platelet - Derived Growth Factor Receptor - Expression in Vascular Smooth Muscle Cells Authors: Jin S, Hansson EM, Tikka S, Lanner F, Sahlgren C, Farnebo F, Baumann M, Kalimo H, Lendahl U Date: 2008 Publication Details: Circulation Research 2008; 102 (12): 1483 - 91

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Liron Bar - Peled, Grand Prize winner and Cell & Developmental Biology category winner, told about his research on the enzyme mTORC1 which regulates eukaryotic cell growth and is deregulated in some common cancers and diabeCell & Developmental Biology category winner, told about his research on the enzyme mTORC1 which regulates eukaryotic cell growth and is deregulated in some common cancers and diabecell growth and is deregulated in some common cancers and diabetes.