Sentences with phrase «in regulation of gene»

This interaction is thought to be important in regulation of gene expression.

This last observation seems to indicate that promoter methylation does not play a significant role in regulation of gene expression between tissues.

Eukaryotic cells produce diverse types of protein - coding and noncoding RNAs, some of which have a direct role in the regulation of gene expression.

Upon salt - stress treatment, Arabidopsis mobilizes a complex set of pathways that includes alterations in the regulation of gene expression and metabolic adjustments that attempt to establish a new

It was while he was working on his doctoral project, wing formation in fruit flies, that a discovery made by other investigators in the lab — of the first microRNA (a small RNA important in the regulation of gene expression) identified in the fly — captured his attention and has held it ever since.

His lab is interested in the regulation of gene expression by mRNA processing in C. elegans and human cells.

«Regarding the other histones, which are major proteins in the regulation of gene expression, we know which enzymes modify them, their functions, and how they are regulated... But for some reason, the functions of histone 1 have not been addressed,» he adds.

A new study suggests that evolutionary changes in the regulation of a gene implicated in perception, behavior, and memory may be partly responsible.

«This is the first piece of evidence that humans may have a faster rate» of change in the regulation of gene expression, notes Caro - Beth Stewart, a molecular evolutionist at the State University of New York, Albany.

It involves detecting micro-RNAs (miRNAs): small, non-coding RNA molecules that are important in the regulation of gene expression.

Beyond their participation in host defense, increasing evidence suggests that these modifications also play important roles in the regulation of gene expression, virulence and antibiotic resistance.

Histones and other proteins, when modified by this process known as acetylation, play critical roles in regulation of gene expression, typically resulting in increased gene expression.

This research tool can be used to better understand the function of histone proteins, which play critical roles in the regulation of gene expression in animals and plants.

This system plays a major role in the regulation of gene activity, and enables the selective expression of different functions in differentiated cell types.

Following this in 2015, an article (Alsaweed et al.) described over 300 novel milk microRNA molecules, components that are known to play a key role in the regulation of gene expression.

If the genes in the chick embryo are very close to those of an ancestral, nonavian dinosaur — and if the changes, over more than 150 million years, have been almost all in regulation of the genes — then we could reactivate the old pattern of regulation.

The results revealed broad changes in the regulation of genes in the female reproductive tract.

MicroRNAs are very small pieces of ribonucleic acid (RNA) and play a central role in the regulation of genes.

«By exploiting the unique nature of GAM data, mathematical models can reliably derive such information, opening the way to identify multiple, group interactions that could play a key role in the regulation of genes,» explains Nicodemi.

Not exact matches

Dean Hamer, the chief of gene structure and regulation at the National Cancer Institute's Laboratory of Biochemistry, wrote recently in Scientific American about his vision of a not - too - distant future in which an imaginary couple, Syd and Kayla, got to tweak the emotional makeup of their fetus.

Concentration dependence and combinatorial regulation together open up a versatile repertoire of pattern - forming mechanisms that can realize the designs encoded in genes.

Interestingly, as many as nine of the genes have been previously associated with some vascular disease and four more are known to be involved in the regulation of vascular tone, supporting the importance of blood vessels in migraine attacks.

The genes we detect are involved in the regulation of cell development, and are specifically important in synapse formation, axon guidance and neuronal differentiation.

But a new study, published today in Nature, has revealed that m6A plays a key role in the regulation of the Sex - lethal (Sxl) gene, which controls sex determination of the fruit fly Drosophila.

Sankar Ghosh, professor of immunobiology at Yale University, explores the regulation of gene expression in developing and differentiating lymphocytes.

Although the regulation of this gene has a strong «cell cycle control» component, I was more interested in studying cell cycle regulation «proper.»

He is interested in reactivating dormant genes or changing the regulation of active genes in embryos to bring back ancestral traits that have been lost in evolution.

Today, a team of researchers from the University of Geneva (UNIGE), Switzerland, led by Emmanouil Dermitzakis, Louis - Jeantet Professor at the Faculty of Medicine, reveals that this is not always the case and that DNA methylation may play both a passive and active role in gene regulation.

For example, the study found down - regulation of genes involved in interferon tau, the major signal of pregnancy recognition.

After having conducted a large - scale study performed on cells from the umbilical cords of 204 newborns, the researchers from UNIGE demonstrate that DNA methylation may play both a passive and active role in gene regulation.

Epigenetic mechanisms give tortoiseshell cats their markings, but are also involved in our development in the womb and the day - to - day regulation of our genes

There already has been great effort to elucidate the mechanisms of gene expression regulation, but it will be important to continue research to fully realize the potential of these epigenetic therapies and their applications in clinical settings.

The whole point of a gene drive is to disperse in the wild, but government regulations are designed to keep genetic engineering out of wild organisms, says Zach Adelman, a molecular biologist at Virginia Tech in Blacksburg.

Nevertheless, gene combination and regulation is more relevant than gene presence in the time - scale of evolution.

RNA interference (RNAi) is a type of gene regulation that naturally occurs in eukaryotes.

Moving from biochemistry to molecular biology, Palatnik started investigating the role of microRNAs — tiny RNA molecules that are important in gene regulation in most life forms — in the development of the plant Arabidopsis.

The newly unmasked genes play a role in three distinctively different bodily functions, including systems that control inflammation and cholesterol and the regulation of how brain cells clean up toxic proteins.

To find answers to these questions, the scientists studied the gene regulation of the DPP4 gene in mice that are prone to obesity.

Experiments in cells with an inactivated form of Argonaute — which contributes only to the antiviral and not the gene regulation activity of RNAi — confirmed that they were observing an antiviral RNAi response.

Research coordinated by Osaka University has now shown that the nuclear protein complex cohesin must be expressed at sufficient levels in the early mouse brain to control gene regulation and allow development of healthy neuronal networks and behavioral characteristics.

In the absence of any international body that would be an obvious fit to enforce international regulations on gene editing there are historical precedents — like stem cell research — for providing guidance and then leaving the specifics up to regional authorities.

A comprehensive map of genome - wide gene regulation in Mycobacterium tuberculosis.

These changes in gene regulation differed from those of mice or rats under the same conditions, the researchers found.

«Rapamycin affected the expression of genes involved in calcium regulation, mitochondrial metabolism, hypertrophy and inflammation,» said Melov.

Unless sufficient cohesin was present in the developing mouse brain, the researchers showed that the regulation of a number of genes was disrupted, leading to neuronal defects and increased anxiety.

The study identified five genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).

The researchers linked the excess weight and changes in metabolism to epigenetic modifications that reduce expression of the gene for adiponectin — a hormone that helps regulate several metabolic processes, including glucose regulation.

Specifically, Toni Gabaldón's group at the Centre for Genomic Regulation in Barcelona has compared the Iberian lynx genome with those of other species, attempting to identify genes that have lost their function because they have remained isolated and the existence of a small population of specimens of this species.

«He was writing in a time before the molecular revolution, before we had much idea of how genes react with one another and the actual molecular basis of changes in genes and their regulation.»

«Changes in genes» regulation — not in the DNA sequence of genes themselves — were the driving force behind successful metastases in our experiments, and, as far as we know, this is the first genomewide experimental evidence for this phenomenon.»