This interaction is thought to be important
in regulation of gene expression.
This last observation seems to indicate that promoter methylation does not play a significant role
in regulation of gene expression between tissues.
Eukaryotic cells produce diverse types of protein - coding and noncoding RNAs, some of which have a direct role
in the regulation of gene expression.
Upon salt - stress treatment, Arabidopsis mobilizes a complex set of pathways that includes alterations
in the regulation of gene expression and metabolic adjustments that attempt to establish a new
It was while he was working on his doctoral project, wing formation in fruit flies, that a discovery made by other investigators in the lab — of the first microRNA (a small RNA important
in the regulation of gene expression) identified in the fly — captured his attention and has held it ever since.
His lab is interested
in the regulation of gene expression by mRNA processing in C. elegans and human cells.
«Regarding the other histones, which are major proteins
in the regulation of gene expression, we know which enzymes modify them, their functions, and how they are regulated... But for some reason, the functions of histone 1 have not been addressed,» he adds.
«This is the first piece of evidence that humans may have a faster rate» of change
in the regulation of gene expression, notes Caro - Beth Stewart, a molecular evolutionist at the State University of New York, Albany.
It involves detecting micro-RNAs (miRNAs): small, non-coding RNA molecules that are important
in the regulation of gene expression.
Beyond their participation in host defense, increasing evidence suggests that these modifications also play important roles
in the regulation of gene expression, virulence and antibiotic resistance.
Histones and other proteins, when modified by this process known as acetylation, play critical roles
in regulation of gene expression, typically resulting in increased gene expression.
This research tool can be used to better understand the function of histone proteins, which play critical roles
in the regulation of gene expression in animals and plants.
Following this in 2015, an article (Alsaweed et al.) described over 300 novel milk microRNA molecules, components that are known to play a key role
in the regulation of gene expression.
Not exact matches
Sankar Ghosh, professor
of immunobiology at Yale University, explores the
regulation of gene expression in developing and differentiating lymphocytes.
This system plays a major role
in the
regulation of gene activity, and enables the selective
expression of different functions
in differentiated cell types.
There already has been great effort to elucidate the mechanisms
of gene expression regulation, but it will be important to continue research to fully realize the potential
of these epigenetic therapies and their applications
in clinical settings.
«Rapamycin affected the
expression of genes involved
in calcium
regulation, mitochondrial metabolism, hypertrophy and inflammation,» said Melov.
The researchers linked the excess weight and changes
in metabolism to epigenetic modifications that reduce
expression of the
gene for adiponectin — a hormone that helps regulate several metabolic processes, including glucose
regulation.
«
Genes code for the sequence of amino acids in proteins, and some are involved in the regulation of the expression of other genes,» he
Genes code for the sequence
of amino acids
in proteins, and some are involved
in the
regulation of the
expression of other
genes,» he
genes,» he says.
However, to make use
of that information required an understanding
of gene expression and
regulation, areas
in which institute members made a conscious decision to invest and that became its strengths.
«Telomerase is a unique protein - RNA complex where the protein subunit uses its RNA component as a template to add identical fragments
of DNA to the end
of chromosomes,» said Emmanuel Skordalakes, Ph.D., associate professor
in the
Gene Expression and
Regulation program
of Wistar's NCI - designated Cancer Center.
The Lazar lab has been working on HDAC3 for over a decade, focusing on the pivotal role
of this enzyme
in hormone - mediated
regulation of gene expression and metabolism.
The results suggest that, although the lack
of light chain synthesis can be due to a lack
of gene rearrangement, there may also be transcriptional
regulation, which may also be important for the
expression of light chain immunoglobulins
in immature B cells.
A new function now described for the protein dDsk2 by the team headed by Ferran Azorín, group leader at the Institute for Research
in Biomedicine (IRB Barcelona) and CSIC research professor, links ubiquitin receptors for the first time with the
regulation of gene expression.
Plants perform these
regulations mainly by regulating nuclear
gene expression and multiple intracellular signaling pathways have been shown to play a role
in the genomic response
of plants to stress, but the processes are not well understood.
The modern study
of gene regulation started
in the 1950s, but researchers only started to unravel the complex array
of histone modifications that fine - tune chromatin control
of gene expression 20 years ago.
An international consortium
of researchers
in the Genotype - Tissue
Expression (GTEx) Consortium published findings about how genetic variation effects
gene regulation in 44 human tissue types.
The research that led to these findings is part
of a larger effort to better understand
gene regulation and
expression, carried out by the GTEx Consortium, a National Institutes
of Health - funded group that includes researchers from around 80 institutions founded
in 2010.
Embryonic development is a well - studied process
in which the precise
regulation of gene expression is critical, since many
genes are expressed simultaneously and
in a punctual manner.
«The disruption
of the circadian clock machinery seems to affect not only the rhythm
of appetite
regulation, but also the
expression of the
genes and proteins at their absolute level,» says Turek, whose team reports its findings online today
in Science.
Among the other
genes she says play a role
in thoroughbred performance are peroxisome proliferator - activated receptor - γ coactivator - 1 alpha (PGC - 1α), which is involved
in skeletal muscle adaptation to exercise; pyruvate dehydrogenase kinase, isozyme 4 (PDK4), involved
in glucose
regulation,
expression of which increased almost fourfold after sprints; and cytochrome c oxidase subunit 4 isoform 2 (COX 4I2), involved
in respiration.
To determine whether shifts
in the balance
of anterior and posterior field occurred during fin - to - limb evolution, Onimaru, postdoctoral researcher currently at Sharpe's lab (CRG), and his colleagues carefully compared the
expression, function and
regulation of genes involved
in anterior - posterior patterning
in pectoral fins
of catsharks, with those
of mice.
In a non-disease state, TDP - 43 is an important protein involved in various aspects of the metabolism of RNA, a molecule essential in various biological roles in the regulation and expression of gene
In a non-disease state, TDP - 43 is an important protein involved
in various aspects of the metabolism of RNA, a molecule essential in various biological roles in the regulation and expression of gene
in various aspects
of the metabolism
of RNA, a molecule essential
in various biological roles in the regulation and expression of gene
in various biological roles
in the regulation and expression of gene
in the
regulation and
expression of genes.
Using this «Ribotag» approach tissue - specific changes under DR have been measured
in muscle, fat, gut, heart, neurons, germline and malpighian tubules, showing a highly tissue specific response upon DR.. We are developing mechanistic models
of gene expression regulation and conducting comprehensive bioinformatics analyses on UTRs, promoters and the coding sequences
of various elements
of differentially regulated
genes.
In a study published online in Genome Research, researchers devised a strategy for genome - wide annotation of primary miRNA transcripts, providing extensive new annotations in human and mouse, and shedding light on mechanisms of regulation of microRNA gene expressio
In a study published online
in Genome Research, researchers devised a strategy for genome - wide annotation of primary miRNA transcripts, providing extensive new annotations in human and mouse, and shedding light on mechanisms of regulation of microRNA gene expressio
in Genome Research, researchers devised a strategy for genome - wide annotation
of primary miRNA transcripts, providing extensive new annotations
in human and mouse, and shedding light on mechanisms of regulation of microRNA gene expressio
in human and mouse, and shedding light on mechanisms
of regulation of microRNA
gene expression.
Scientists have discovered many points
of regulation in the process
of using a specific DNA template to make a protein, known as
gene expression, that allow the cell to control how much
of a certain protein is made at a certain time.
One is straightforward — during development, cells are assuming their identities and need precise control over protein production, so cells lacking a
gene expression regulation mechanism are bound to have defects, particularly
in the case
of specialized cells like neurons.
Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated
in to the
regulation of gene expression and modulation
of the host immune response during ¿ - herpesviral infection.
In this review article, we highlight transcriptional regulation of gene expression in response to drought.&raqu
In this review article, we highlight transcriptional
regulation of gene expression in response to drought.&raqu
in response to drought.»
He received his doctoral degree
in 1996 at the Ludwig Maximilians University
in Munich for work on activity - dependent
regulation of neurotrophin
gene expression.
Along this line, our primary research goals are directed towards understanding how noncoding RNAs and their RNA - binding proteins are integrated
in to the
regulation of gene expression and modulation
of the host immune response during gammaherpesvirus infection.
Compared with the ancestral lineage, the East African cichlid genomes possess: an excess
of gene duplications; alterations
in regulatory, non-protein-coding elements
in the genome; accelerated evolution
of protein - coding elements, especially
in genes for pigmentation; and other distinct features that affect
gene expression, such as insertions
of transposable elements and
regulation by novel microRNAs.
Our technological expertise ranges from the most fundamental approaches to study membrane transport
in lymphocytes and dendritic cells (subcellular compartmentalization, intravital microscopy, phagosomal functions), the systematic analysis
of gene expression and it
regulation (RNAseq, Chip Seq, proteomics) and physiological and pathological immune responses (mouse models for cancer immunity, immunomodulation / vaccination, human clinical studies
in cancer).
We have also initiated studies
of the
regulation of cytokine
gene expression in these cells.
Exposing S. pistillata to seawater with an elevated calcium concentration resulted
in up -
regulation of gene expression during the day relative to the night.
Benedikt received his doctoral degree
in 1996 at the Ludwig Maximilians University, Munich for work on activity - dependent
regulation of neurotrophin
gene expression.
With respect to the host's transcriptome, alcohol feeding was associated with down -
regulation in gene and protein
expression of bactericidal c - type lectins Reg3b and Reg3g
in the small intestine.
Brain
expression and song
regulation of the cholecystokinin
gene in the zebra finch (Taeniopygia guttata).
We found an excess
of gene duplications
in the East African lineage compared to tilapia and other teleosts, an abundance
of non-coding element divergence, accelerated coding sequence evolution,
expression divergence associated with transposable element insertions, and
regulation by novel microRNAs.
The work has led him to explore the role
of protein phosphorylation
in a diverse array
of cellular functions, including transformation, cell communication, cell adhesion, cell - cycle
regulation, the control
of gene expression, and protein degradation.