Sentences with phrase «in sialic»
HIBM is caused by mutations in the gene encoding the key enzyme in sialic acid synthesis, UDP - GlcNAc 2 - epimerase / ManNAc kinase, which in turn leads to sialic acid deficiency.
https://www.genome.gov/
Recent studies have shown multiple differences between humans and apes in sialic acid (Sia) biology, including Siglecs (Sia - recognizing - Ig - superfamily lectins).
Not exact matches
«We discovered that Neu1, a protein nicknamed after «neuraminidase 1,» turns the absorption of sugar «on» or «off» in body cells, by regulating the amount of sialic acid on the surface of cells,» Dr. Pshezhetsky explains.
Therapy with Ace - ER led to dose - dependent increases in serum sialic acid levels.
In previous work, Anthony's group and others have found that the anti-inflammatory effect of high - dose IVIG can be attributed to a minor fraction of antibodies to which a glycan called sialic acid has been attached to their Fc region.
The treatment consists of providing N - acetylmannosamine, which forms sialic acid in the body.
Dr. Huizing also studies other sialic acid - related diseases, including sialuria, a progressive disease in which patients produce excess sialic acid.
Without adequate supplies of sialic acid, progressive muscle degeneration (or myopathy) sets in.
In ISSD and Salla disease, other sialic acid - related conditions, a transport malfunction causes sialic acid to accumulate in lysosomeIn ISSD and Salla disease, other sialic acid - related conditions, a transport malfunction causes sialic acid to accumulate in lysosomein lysosomes.
Sialic acid synthesis is tightly regulated; defects in this pathway cause a variety of disorders, including hereditary inclusion body myopathy (HIBM), sialuria, infantile sialic acid storage disease (ISSD), and Salla diSialic acid synthesis is tightly regulated; defects in this pathway cause a variety of disorders, including hereditary inclusion body myopathy (HIBM), sialuria, infantile sialic acid storage disease (ISSD), and Salla disialic acid storage disease (ISSD), and Salla disease.
fad genes, the actP - acs operon, and putative sialic acid uptake and metabolism genes (t1787 - t1790) were upregulated in all strains following bile exposure, which may represent adaptation to the small intestine environment.
The cellular localization of the polymers was confirmed by subcellular fractionation of the cells, followed by digestion with endoglycosidase H (Figure 2C and Supplemental Figure 3C), an enzyme that removes N - linked glycans still in the high mannose ER form but does not affect oligosaccharide chains after the addition of sialic acid in the Golgi apparatus.
[5] Varki A, Gagneux P. Multifarious roles of sialic acids in immunity.
Adding plausibility, «both autoantigens related to Hashimoto disease [thyroid peroxidase and / or thyroglobulin] are glycoproteins and N - linked carbohydrates containing sialic acids have been detected in both molecules.»
Presumably free sialic acid is made available to such pathogens by other, sialidase - expressing bacteria living in the same niche, or... by host sialidases that are activated in the course of inflammation.