Sentences with phrase «in silico analysis»

Advances in high - throughput DNA sequencing and improved methods for in silico analysis of metagenomic data will be necessary to fully characterize these metagenomes and their associated resistomes.

Firstly, we carried out an in silico analysis that identified members of the TGF - β superfamily, including BMPR2 and ACVR2A, as targets of miR - 181a.

The in silico analysis highlighted several candidate TSAs, but one was particularly striking: a missense mutation (p.R913L) in Spnb2, encoding the spectrin beta - 2 protein.

To investigate whether or not somatic coding mutations contributed to the different antigenicity observed between clones, the authors undertook an in silico analysis of predicted MHC class I binding affinity for each allele of missense mutations.

The affected amino acids are highly conserved, and in silico analyses including comparative protein modelling predict that they will interfere with protein function.

Not exact matches

There, I performed the spectroscopic analysis of the in silico predicted protein - ligand pairs of endocrine disruptors and breast cancer proteins using circular dichroism, native mass spectrometry and microscale thermophoresis.

These webtools make use of the multilayered datasets from the BXD mouse population to expedite in silico gene function prediction through a series of integrative and complimentary systems analytical approaches, including (expression - based) phenome - wide association, transcriptome - / proteome - wide association, and (reverse --RRB- mediation analysis.

The webtools make use of the multilayered datasets from the BXD mouse population to expedite in silico gene function prediction through a series of integrative and complimentary systems analytical approaches, including (expression - based) phenome - wide association, transcriptome - / proteome - wide association, and (reverse --RRB- mediation analysis (Figure 1 - 2).

Methods: Comparative analysis of 36 genomes representative of the Lp species was used to identify specific PCR targets, which were then evaluated in silico on 545 sequenced genomes and in vitro on 436 Legionella strains, 106 respiratory samples, and three environmental samples from proven ST47 sources.

In - silico analysis can yield important insights into this aspect, facilitating comparison of two or more classes of genes comprising of a large number of genes within each group.

We combine biochemical, structural, cellular and functional information using purified proteins, mutant and transgenic plants, yeast and chemical genomic screening systems, transient gene expression assays, confocal microscopy and in silico data analysis to compare ROP - centered kinase signaling during cell polarity (in vitro pollen tubes), morphogenesis (whole plant) and pathogenesis (fungi - infected cells).

I agree with nearly all of their analysis of diseases and microbe - vitamin D interactions, but I don't trust the «in silico» computer modelling they do and don't believe their proposed therapies are optimal.