Sentences with phrase «in single genes»

AGTC's lead product candidates focus on rare diseases of the eye, caused by mutations in single genes, that significantly affect visual function and currently lack effective medical treatments.

Earlier cases of resistance were largely due to mutations in single genes — trump cards that immediately made for invincible parasites.

Technological advances in genetic analysis have uncovered changes in single genes that account for a surprising number of infantile and early - childhood epilepsies.

«This is an important finding that will help future researchers, and eventually physicians, to maximize the effectiveness of gene therapy for curtailing sensory deficits associated with USH3 syndrome and, perhaps, in other disorders linked to defects in single genes,» said Alagramam.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

Many are known to be caused by mutations in single genes, yet for the vast majority no treatments are available.

anemia and others result from a misplaced base letter in a single gene.

This suggested that obesity in both obese and db mouse strains resulted from a mutation in a single gene in each case.

In 1986 my research group at the Rockefeller University and another led by Jeffrey Hall of Brandeis University and Michael Rosbash of the Howard Hughes Medical Institute at Brandeis found that the three mutant flies had three different alterations in a single gene named period, or per, which each of our teams had independently isolated two years earlier.

A rare condition that causes a person be born without fingerprints can now be explained by a mutation in a single gene, a new analysis suggests

SMA1 is a progressive, childhood, neuromuscular disease caused by a mutation in a single gene.

Almost immediately such familial genome sequencing proved its value, uncovering mutations responsible for diseases caused by defects in a single gene.

Unlike other autoimmune disorders with associated risk factors, APECED is clearly caused by a mutation in a single gene, based on analyses of affected families.

Could the solution be found in a single gene, asks Bob Holmes

McCauley's interest is cystic fibrosis, a disease caused by mutations in a single gene, CFTR.

Cystic fibrosis is a rare inherited disease caused by mutations in a single gene called cystic fibrosis transmembrane conductance regulator (CFTR) and affects 1 in every 2500 newborns in the UK and over 90000 people worldwide.

In other words, type 2 diabetes could never make it into the Finnish Disease Heritage, where a change in a single gene is decisive.

In skin tumors the process can start with a change in a single gene, such as H - ras.

A mutation in a single gene produced extra sweat glands in Asian people's skin, perhaps to help them keep cool in the warm and humid climate

Three will hunt for mutations underlying rare inherited diseases caused by a glitch in a single gene.

How kind you are could be affected by a change in a single gene.

Humans and chimps each have somewhere between 20,000 and 30,000 genes, so there are likely to be nucleotide differences in every single gene.

But many researchers, including Keller and Ross, didn't think variations in a single gene could account for all the differences in size, fertility, odor, and aggression that separated the two ant groups.

Researchers once thought that the groups» distinct physiological and behavioral profiles stemmed from a variant in a single gene.

Fragile X, which is caused by a mutation in a single gene on the X chromosome, affects about 1 in 4,000 men and 1 in 6,000 women.

Cystic fibrosis is a hereditary disease caused by mutations in a single gene called CFTR.

And story number 4: Variations in a single gene can determine whether you perceive male sweat as odorless or smelling like vanilla or like urine.

Studies of worms and fruit flies show that variations, or polymorphisms, in a single gene can affect how long these creatures live.

Rare genetic diseases like LFS are good study models because they tend to proceed from a change in a single gene, as opposed to many, overlapping changes seen in more related common diseases, in this case more common, non-inherited bone cancers.

Each strain contains an alteration in a single gene, the structure of which must be verified prior to breeding and phenotyping.

Professor Cattaneo's laboratory works on Huntington's Disease, a brain neurodegenerative disease caused by the mutation in a single gene.

SMA1 is a devastating, progressive neuromuscular disease in infants caused by a mutation in a single gene, SMN.

About Spinal Muscular Atrophy Spinal Muscular Atrophy is a genetic, motor neuron disease caused by mutations in a single gene, SMN1.

The tool, in particular, could be ideal for both these diseases, scientists think, because each is caused by mutations in a single gene that makes hemoglobin, the protein in the red blood cells that transports oxygen throughout the body.

Howard Hughes Medical Institute (HHMI) researchers have identified subtle defects in a single gene that underlie a hereditary form of age - related macular degeneration, the leading cause of...

What's more, inherited diseases can arise from a problem with one gene (a simple example is sickle - cell anemia, a condition caused by defects in a single gene that makes the hemoglobin protein), or from interactions among a range of genetic variations as well as, frequently, environmental stresses.

In humans, PKD is one of the most common diseases caused by a mutation in a single gene.

Phenotypes that result from changes (i.e., variants) in a single gene (i.e., monogenic) and that can be transmitted from parents to offspring in Mendelian patterns, such as autosomal dominant, autosomal recessive, X-linked, are known as Mendelian phenotypes.

The most common genetic killer of infants, a disease known as spinal muscular atrophy, is caused by mutations in a single gene.

In contrast to Mendelian disorders (e.g., Huntington's disease, sickle cell anemia) in which variation in a single gene causes disease, common complex disorders, such as heart disease, diabetes, and most cancers, develop as a result of both genetic and environmental factors.

I think that the cure for schizophrenia can be found in a single gene.

Research on the CREB gene emphasizes the reductionist approach, in which elements of the complex phenomenon of memory formation are reduced to mutations in a single gene and studied in a simple model system, the fruit fly Drosophila

A mutation in a single gene has been linked to cases of severe obesity, offering scientists new targets for future gene therapy drugs (Credit: < a href ="https://depositphotos.com/19154541/stock-photo-serious-doctor-examining-a-patient.html" rel="nofollow"> sunabesyou / Depositphotos )

A mutation in a single gene has been linked to cases of severe obesity, offering scientists new targets for future gene therapy drugs (Credit: sunabesyou / Depositphotos)

Unlike rare diseases, which typically stem from mutations in a single gene, common diseases emerge from mutations in multiple genes, sometimes tens or even hundreds of them.

A mutation in a single gene has been linked to cases of severe obesity, offering scientists new targets for future gene therapy drugs

Among the specific findings is the confirmation that mutations in a single gene, TP53, are present in more than 96 percent of all such cancers.

Take cystic fibrosis, a genetic disease that creates a life - threatening accumulation of mucus in the lungs and is known to result from a single mutation in a single gene.

Body size in dogs, for example, can range from 3 to 300 pounds, and is thought to be due to a small variation in a single gene (the IGF - 1 gene).

Not exact matches

Here's why: In the late 90s, technology emerged enabling researchers to rapidly sequence RNA and DNA — giving them the ability to isolate and record the activity of single genes.