Sentences with phrase «in skeletal development»

This myth has not been supported by scientific or clinical evidence; one study found no difference in the skeletal development of great Dane puppies raised on diets with the same energy content but containing different protein concentrations (8).

This happens when there is a mutation of the FGFR3 gene (the gene responsible for producing a protein that develops and maintains the growth of bone and brain tissue), which then causes disruptions in skeletal development.

Professor Cyrus Cooper, Director of the MRC Lifecourse Epidemiology Unit, University of Southampton, comments: «This study highlights an important link between diabetes and osteoporosis, and identifies a selective deficit in skeletal development, which leads to excess fracture risk in this increasingly frequent disorder.

Not exact matches

A: Spinal care is vital in early months and years to ensure the correct development of baby's skeletal structure.

We aimed to determine if the reported differences in calcium absorption could affect skeletal development by comparing bone mineral accretion in healthy term infants fed a milk - based formula with (PMF) or without PO.

Working with Skeletal Biologists at Southampton General Hospital, Catarina is investigating new optical techniques to monitor the development of the cells, used in new regenerative medicine approaches — in this case, to create and grow cartilage from human stem cells.

Comparisons of the Neandertal genome to the genomes of five present - day humans from different parts of the world identify a number of genomic regions that may have been affected by positive selection in ancestral modern humans, including genes involved in metabolism and in cognitive and skeletal development.

Vitamin D optimises calcium absorption and therefore plays an essential role in bone mineralisation and skeletal development.

The extra bone that appears in FOP flare - ups progresses through a cartilage stage before replacement with mature bone cells, following a sequence of bone formation seen during normal skeletal development.

Scientists at the University of Southampton have shown that higher muscle mass is strongly linked with healthier bone development in children.Researchers also found no relationship between fat mass and bone development, indicating it is not an important factor in childhood skeletal strength.

«One major adaptation is a positive selection for genes involved in hypoxia response and skeletal development, similar to those expressed in other organisms in high - altitude environments such as Tibet and the Andes,» Dr Subramanian said.

Some of these genes control both cardiovascular development and skeletal development, suggesting the intriguing possibility that the giraffe's stature and turbocharged cardiovascular system evolved in concert through changes in a small number of genes.

Interestingly, when these same genes go awry in humans, they cause bone - development disorders called skeletal ciliopathies.

Adolescence is the key period for bone development, and poor development at this stage is linked to reduced peak bone mass (the amount of bone mass at the end of the skeletal maturation, around age 30), increased fracture risk and osteoporosis later in life.

Some occur in genes that play a role in skeletal growth and development, which makes sense, but others lie in genes that trigger cancer or in undeciphered regions of DNA.

However, malformation of skeletal bones during embryogenesis also occurs in FOP patients and illustrates that the underlying genetic mutation occurs in a gene with functional importance in regulating chondro - osseous differentiation during embryonic skeletal development as well as in adult musculoskeletal tissues.

In addition, the altered rates of force development and relaxation suggest alterations in the regulation of intracellular calcium levels following maximal contractions, as are noted to occur in slow skeletal muscles (44In addition, the altered rates of force development and relaxation suggest alterations in the regulation of intracellular calcium levels following maximal contractions, as are noted to occur in slow skeletal muscles (44in the regulation of intracellular calcium levels following maximal contractions, as are noted to occur in slow skeletal muscles (44in slow skeletal muscles (44).

The gene, known as gata5, acts in embryonic cells, which are primordial, unspecialized cells that form in the earliest stage of embryonic development and are genetically programmed to evolve into one of many specialized cell types, such as skeletal muscle cells, nerve cells, blood cells, skin cells, and liver cells.

However, Setd7 expression increased with the progression of myogenesis in vitro indicating the potential importance of this event for skeletal muscle development and regeneration in vivo.

Better understanding of mechanisms underlying skeleton development, adult maintenance, and diseases has led in recent years to new and improved treatments for osteoporosis and a few other conditions, but today most skeletal diseases remain untreatable or incompletely treatable.

A drug known as SR9009, which is currently under development at The Scripps Research Institute (TSRI), increases the level of metabolic activity in skeletal muscles of mice.

They also include the development of protocols to derive healthy skeletal cell types from patient - derived pluripotent stem cells and thereby to generate or regenerate healthy skeletal tissues in vivo.

Like the variants previously discovered by deCODE, certain of those reported today are known to be involved in bone and skeletal development.

New SOXC projects in the laboratory are addressing the roles of SOXCs in other skeletal cell types in development, in adult skeleton maintenance, and in human diseases.

The Center for Biomedical Research Excellence in Skeletal Health and Repair and the Rhode Island IDeA Network for Excellence in Biomedical Research are supported by the National Institutes of Health's Institutional Development Award (IDeA) program under grant numbers P20GM104937 and P20GM103430, respectively.

The authors highlight the successful application of both induced pluripotent stem cells and embryonic stem cells for this first example of the in vitro formation of functional and mature skeletal muscle tissue, thereby also establishing the potential for patient - specificity in disease modeling, drug development, and possible muscle repair.

Embryo - fetal development studies carried out on mice and rats also observed a reduced number of pups per litter, reduced pup weight at birth, and an increased frequency of skeletal «variations» in pups after pregnant females were given high doses of DEP.

In infants, thyroid hormones are crucial to the development of the brain and the skeletal system.

Although the fetal skeleton begins developing early in gestation, it is late in the third trimester when the bulk of fetal skeletal development takes place.

They are also required for proper skeletal and central nervous system development in fetuses and infants [1].

Animal and clinical studies indicate that the AR signaling pathway is required for appropriate development of skeletal muscles, since it regulates increases in lean muscle mass, muscle strength, and muscle protein synthesis.

Gehlert, S., et al., High force development augments skeletal muscle signalling in resistance exercise modes equalized for time under tension.

Researchers believe that the breeds most commonly affected are the «chondrodystrophic» ones in which an abnormal development of the bones results in various skeletal disproportions, such as short legs and noses.

Another major factor in the development of skeletal disease in young growing dogs is too much calcium intake.

Environmental factors play a part in shaping the growing puppy, but skeletal development is governed by the action of genes.

Calcium and phosphorus are critical in the continuing development of the skeletal system.

Puppy food contains more calcium than adult food to aid in the development of the puppy's skeletal bone structure and teeth.

This is not desirable, because it is incompatible with proper skeletal development and also contributes to obesity later in life.

The effects of prepubertal gonadectomy on skeletal, physical, and behavioral development are similar to those seen in animals that are neutered at a more traditional age.

Because of the significant increase in body weight, it is important a giant breed puppy be fed a diet that supports healthy skeletal and muscular development.

The vets here in America for the most part totally dismiss the effects of hormones on the dogs skeletal development.

Nap RC, Hazewinkel H. Growth and skeletal development in the dog in relation to nutrition; a review.

Prepubertal gonadectomy in the domestic feline: Effects on skeletal, physical and behavioral development.

Large breed puppies typically have a genetic tendency to grow too quickly and this can sometimes result in incomplete skeletal development and lifelong joint issues.

The rabbit has higher needs for calcium and phosphorus to allow for skeletal development of the fetuses and adequate levels in the milk.

In a 15 - month study, the effects of prepubertal gonadectomy on skeletal growth, weight gain, food intake, body fat, secondary sex characteristics, and behavioral development were investigated in 32 mixed - breed dogIn a 15 - month study, the effects of prepubertal gonadectomy on skeletal growth, weight gain, food intake, body fat, secondary sex characteristics, and behavioral development were investigated in 32 mixed - breed dogin 32 mixed - breed dogs.

(rptref1, rptref2, rptref3, ref4, ref5) As these youngsters mature, veterinarians see a variety of skeletal abnormalities in them because proper bone development and bone maturation sequence also depend on adequate thyroid hormone.

Mineral Balance (calcium / Phosphorus) Helps support healthy skeletal development in medium breed puppies with an adapted calcium and phosphorus content.

Feeding a dog of a large breed with a diet exceeding the National Research Council (1974) recommendations for energy, protein, calcium, phosphorus and vitamin D may result in disturbances of skeletal development.

The differences in protein intake per se had no demonstrable consequences for calcium metabolism and skeletal development.