Sentences with phrase «in skeletal muscle cells»

The recent recognition that de novo lipogenesis might have relevance for lipid homeostasis in skeletal muscle stems from the realization that Sterol regulatory element binding protein - 1c (SREBP - 1c), a member of the family of transcription factors that regulate the expression of genes involved in lipid storage in liver and adipose tissue, is also present in skeletal muscle at a level close to that observed in the liver, 41,42... [M] ost fascinating are the very recent demonstrations that glucose alone (in the absence of insulin) can stimulate de novo lipogenesis in skeletal muscle cells....

Leucine facilitates the insulin - stimulated glucose uptake and insulin signaling in skeletal muscle cells: involving mTORC1 and mTORC2.

Hirabara SM, Curi R, Maechler P. Saturated fatty acid - induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells.

LPL activation in skeletal muscle cells and its suppression in adipocytes by Cy -3-g were blocked by inhibition of pAMPK.

Myostatin, a member of the TGFβ superfamily of growth factors that is expressed primarily in skeletal muscle cells, is a genetically validated target that regulates muscle mass.

Dr. Espen Spangenburg, associate professor of kinesiology, and his laboratory team are the first to identify that the BRCA1 protein is expressed in the skeletal muscle of both mice and humans, and that it plays a key role in fat storage, insulin response and mitochondrial function in skeletal muscle cells.

Not exact matches

Multi-nucleus cells expressing genes needed to form skeletal muscle can be seen in flower - like clumps forming as cells fuse together.

«In normal conditions, skeletal muscle is a self - healing tissue and can recover promptly from most trauma because of the satellite cells.

Specialized stem cells known as satellite cells reside in skeletal muscle in an inactive state.

Researchers at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies for diseases such as muscular dystrophy.

Once the UCLA researchers had produced iPS cells that were free from Duchenne mutations, they differentiated the iPS cells into cardiac muscle and skeletal muscle cells and then transplanted the skeletal muscle cells into mice that had a genetic mutation in the dystrophin gene.

Among the 19 study volunteers who lost 5 percent of their body weight, the function of insulin - secreting beta cells improved, as did insulin sensitivity in fat tissue, liver and skeletal muscle tissue.

«While these tumors appear to be muscle cells under the microscope, and clinicians had thought that they arose from muscle progenitor cells, that didn't explain why the tumors can occur in tissues that don't have skeletal muscle, like bladder, prostate and liver,» he continued.

«Under no circumstances should it be concluded from our work that consumption of marijuana can be a way to cure diabetes,» Prof. Dobrzyn warns and explains: «The concentration of glucose in the blood is determined by the balance between the activities of alpha and beta cells of the pancreas and insulin target tissues such as skeletal muscle and adipose tissue.

This shows fat accumulation (green) in human skeletal muscle cells (red) that either express BRCA1 (left) or do not express BRCA1 (right).

This was done using shRNA technology specific for BRCA1 in human myotubes (skeletal muscle fiber cells).

The hamburger was grown in Post's lab using bovine skeletal muscle stem cells, collected from a piece of fresh beef.

«This is a clean demonstration that the physiological and metabolic benefits of exercise radiate to skeletal muscle satellite cells, the adult stem cells responsible for repair after injury, even in senescent animals,» said Thoru Pederson, Ph..

«People used to think that this region of the medulla was only involved in the paralysis of skeletal muscles during REM sleep,» said lead author Yang Dan, a UC Berkeley professor of molecular and cell biology and a Howard Hughes Medical Institute Investigator.

«The vitamin D receptor is expressed in insulin - secreting pancreatic beta cells and in peripheral target tissues such as skeletal muscle and adipose tissue.

Once they were able to isolate skeletal muscle cells using the newly identified surface markers, the research team matured those cells in the lab to create dystrophin - producing muscle fibers.

These cells can be used in a variety of tissue types, including bone, cartilage, fat, skeletal muscle, smooth muscle and cardiac muscle.

In vitro experiments in myogenic cells initially suggested that IL - 15 was an anabolic factor for skeletal muscle, able to stimulate the accumulation of contractile protein in differentiated myotubes (8 — 10In vitro experiments in myogenic cells initially suggested that IL - 15 was an anabolic factor for skeletal muscle, able to stimulate the accumulation of contractile protein in differentiated myotubes (8 — 10in myogenic cells initially suggested that IL - 15 was an anabolic factor for skeletal muscle, able to stimulate the accumulation of contractile protein in differentiated myotubes (8 — 10in differentiated myotubes (8 — 10).

Pennington Biomedical's research enterprise includes approximately 70 world - class faculty researchers and specialists in neuroscience, stem cell biology, skeletal muscle biology, statistical genetics, diabetes, behavior modification, eating disorders and other areas.

Human triglyceride - rich lipoproteins impair glucose metabolism and insulin signalling in L6 skeletal muscle cells independently of non-esterified fatty acid levels.

It is characterized by the wasting of skeletal muscles and caused by progressive degeneration of nerve cells in the spinal cord; the disease leads to increasing muscular weakness, atrophy and premature death due to respiratory problems.

The findings in a recent issue of Cell demonstrate how PGC - 1a1, a transcriptional coactivator induced in skeletal muscle by exercise and endurance, protects the brain from depression.

We investigated the role of Srf in two cellular compartments of mouse skeletal muscle (myofibers and adult muscle stem cells) upon different perturbation of muscle homeostasis (hypertrophy, atrophy, regeneration).

These endogenous muscle stem cells promote regeneration of skeletal muscles after injury and that participate in adaptation to exercise.

Characterized other proteins and pathways that modulate proliferation and differentiation of myogenic stem cells, hypertrophic growth of the heart, mitochondrial biogenesis and fiber type — specific gene expression in skeletal muscles.

The gene, known as gata5, acts in embryonic cells, which are primordial, unspecialized cells that form in the earliest stage of embryonic development and are genetically programmed to evolve into one of many specialized cell types, such as skeletal muscle cells, nerve cells, blood cells, skin cells, and liver cells.

Expression of MyoD, a skeletal muscle - specific transcriptional regulator, activated the expression of the Cdk inhibitor p21 during differentiation of murine myocytes and in nonmyogenic cells.

Infiltrating cells in the myocardium and skeletal muscle were positive for the T - cell marker CD3 or the macrophage marker CD68.

A genetic approach in the mouse has been used to examine how skeletal muscle stem cells are born, and how they acquire their identity.

Abstract We discovered that a subset of satellite cells in skeletal muscle are self - renewing stem cells that give rise to myogenic progenitors through asymmetric apical - basal cell divisions.

Using mouse skeletal muscle stem cells as a model, we show that accumulating transcripts specifying the myogenic program are not translated in quiescent satellite cells, but are repressed by the action of microRNAs and RNA binding proteins.

p38 MAPK signaling underlies a cell - autonomous loss of stem cell self - renewal in skeletal muscle of aged mice.

IGF prevents frailty by increasing skeletal muscle mass (sarcopenia), sex drive (infertility), brain thymus (immunosenescence, centenarians maintain a strong immune system), skeletal bone mineralization and marrow stem cell formation (osteoporosis and immune system by bone marrow immune cells working in tandem with thymus and lymphs nodes), I understand that diabetes, an accelerated aging phenotype, is insulin IGF and blood glucose driven.

MyoD is normally only expressed in skeletal muscle, and it was later found to be a transcription factor involved in the differentiation of muscle cells and also a very early marker of muscle cell fate commitment.

A second line of research is to use skeletal muscle formation in the chick embryo as a model to understand how cells within tissues display complex behaviours while being exposed to an ever - changing cellular environment.

(6) This is consistent with the deleterious effect of such cells on tissue function, and with the researchers» conclusion that «the observed improvements in skeletal muscle and fat of late - life treated 10 - month - old BubR1H / H; INK - ATTAC - 5 mice reflect attenuated progression of age - related declines rather than a reversal of ageing».

Roberts, E. W. and Deonarine, A. and Jones, J. O. and Denton, A. E. and Feig, C. and Lyons, S. K. and Espeli, M. and Kraman, M. and McKenna, B. and Wells, R. J. B. and Zhao, Q. and Caballero, O. L. and Larder, R. and Coll, A. P. and O'Rahilly, S. and Brindle, K. M. and Teichmann, S. A. and Tuveson, D. A. and Fearon, D. T. (2013) Depletion of stromal cells expressing fibroblast activation protein - alpha from skeletal muscle and bone marrow results in cachexia and anemia.

In this study, Chazaud et al., evidenced that endothelial cells (ECs) and myogenic progenitor cells (MPCs) interacted to couple myogenesis and angiogenesis during skeletal muscle regeneration.

Title: Numb Promotes an Increase in Skeletal Muscle Progenitor Cells in the Embryonic Somite Authors: Jory A, Le Roux I, Gayraud - Morel B, Rocheteau P, Cohen - Tannoudji M, Cumano A, Tajbakhsh S Date: 2009 Publication Details: Stem Cells; Volume 27, Issue 11.

The candidate must have an experience working in the biology and physiology of skeletal muscle, with a reference to in vitro / ex vivo muscle cell contraction.

Human satellite cell cultures display numerous features of mature skeletal muscles (1) and have been used for studies of muscle metabolism in cultures established from patients with type 2 diabetes and healthy control subjects (1 — 5,8,9,21,22).

Another example is AMDC — autologous adult skeletal muscle primary cells that are expanded in culture prior to injection and are tested for the treatment of ischemic heart failure.

In chick embryos, skeletal muscle formation is initiated by migrating Delta1 - expressing neural crest cells that trigger NOTCH signaling and myogenesis in selected epithelial somite progenitor cells, which rapidly translocate into the nascent muscle to differentiatIn chick embryos, skeletal muscle formation is initiated by migrating Delta1 - expressing neural crest cells that trigger NOTCH signaling and myogenesis in selected epithelial somite progenitor cells, which rapidly translocate into the nascent muscle to differentiatin selected epithelial somite progenitor cells, which rapidly translocate into the nascent muscle to differentiate.

Currently, back at the University of warsaw, she heads the Department of Cytology which investigates the potential of various stem cells to differentiate into myoblasts and to participate in the regeneration of skeletal muscle.

The decline in skeletal muscle function associated with human ageing can be ascribed to an increasing number of mutations in satellite cells — the resident stem cells of skeletal muscle.