Sentences with phrase «in skeletal tissue»

«As an animal eats and drinks, the local strontium isotope composition of the water, plants and animals consumed is recorded in its skeletal tissues.»

Carnitine's highest concentrations in skeletal tissues and heart muscles.4, 5 The US Food and Drug Administration (FDA) has approved L - carnitine for treatment of carnitine deficiencies.6

Not exact matches

What do they know about the earliest vertebrate environment and some aspects of dermal skeletal tissue or the Opaque 2 function in maize?

«In normal conditions, skeletal muscle is a self - healing tissue and can recover promptly from most trauma because of the satellite cells.

Palaeontologists can date when our ancestors lost the organ, as the tissue attaches to a skeletal feature called the hyoid bulla, which is absent in humans.

Skeletal muscle is one of the largest tissues in the human body and current gene therapy methods are only able to affect a portion of the muscle.

Among the 19 study volunteers who lost 5 percent of their body weight, the function of insulin - secreting beta cells improved, as did insulin sensitivity in fat tissue, liver and skeletal muscle tissue.

«While these tumors appear to be muscle cells under the microscope, and clinicians had thought that they arose from muscle progenitor cells, that didn't explain why the tumors can occur in tissues that don't have skeletal muscle, like bladder, prostate and liver,» he continued.

Furthermore, in heart tissue from these mice, the scientists found genes turned on that are normally seen in skeletal muscle, not heart muscle.

Results of a study conducted by researchers at the University of Pittsburgh School of Medicine and the McGowan Institute for Regenerative Medicine showed significant improvement in strength and range of motion, as well as evidence for skeletal muscle regeneration, in 13 patients who were surgically implanted with bioscaffolds derived from pig tissue to treat muscle injuries.

«Under no circumstances should it be concluded from our work that consumption of marijuana can be a way to cure diabetes,» Prof. Dobrzyn warns and explains: «The concentration of glucose in the blood is determined by the balance between the activities of alpha and beta cells of the pancreas and insulin target tissues such as skeletal muscle and adipose tissue.

«We achieved this in the skeletal muscle tissue, which is absolutely unique.

The velociraptor that stalks the protoceratops in the diorama is also based on a series of educated guesses about skeletal and soft - tissue structure, with one added consideration: This velociraptor has feathers.

«The protocol teaches every step of building a bio-bot, from 3D printing the skeleton to tissue engineering the skeletal muscle actuator, including manufacturers and part numbers for every single thing we use in the lab,» explained Ritu Raman, now a postdoctoral fellow in the Department of Bioengineering and first author of the paper, «A modular approach to the design, fabrication, and characterization of muscle - powered biological machines.»

«The vitamin D receptor is expressed in insulin - secreting pancreatic beta cells and in peripheral target tissues such as skeletal muscle and adipose tissue.

In tissues such as liver and skeletal muscle, FAO can provide over 75 % of cellular adenosine triphosphate, while in cardiac tissue it can be responsible for up to 90 In tissues such as liver and skeletal muscle, FAO can provide over 75 % of cellular adenosine triphosphate, while in cardiac tissue it can be responsible for up to 90 in cardiac tissue it can be responsible for up to 90 %.

These cells can be used in a variety of tissue types, including bone, cartilage, fat, skeletal muscle, smooth muscle and cardiac muscle.

Skeletal muscle tissue also produces increased amounts of iNOS and TNF - α in obese compared with lean rodents and humans (21, 71).

Northern analysis revealed that in three of these lines the transgene was expressed in skeletal muscles but not in any of the non-skeletal muscle tissues examined (Figure 1); in the fourth line, Z111B, the expression of the transgene was below the level of detection in these blots.

However, malformation of skeletal bones during embryogenesis also occurs in FOP patients and illustrates that the underlying genetic mutation occurs in a gene with functional importance in regulating chondro - osseous differentiation during embryonic skeletal development as well as in adult musculoskeletal tissues.

These data demonstrate a preferential effect of loss of IL - 15Rα on normalized skeletal muscle mass that is not seen in non-skeletal muscle tissue (i.e., heart, spleen, kidney).

That includes Melov's own study of seniors that revealed strength training exercise reverses aging in human skeletal tissue.

Our laboratory focuses on understanding gene regulation in the cardiovascular system, skeletal muscle, and other metabolic tissues, with the ultimate goal of finding novel therapeutic strategies to prevent and treat cardio - metabolic and - myopathic diseases.

Abstract Skeletal muscle is a major site of metabolic activity and the most abundant tissue in the human body accounting for almost 40 % of the total body mass.

These results imply that mutations in the gene encoding RyR1 will not only affect skeletal muscles, but other tissues that express this calcium channel as well, thereby broadening the clinical spectrum of disorders due to RyR1 dysfunctions.

A second line of research is to use skeletal muscle formation in the chick embryo as a model to understand how cells within tissues display complex behaviours while being exposed to an ever - changing cellular environment.

(6) This is consistent with the deleterious effect of such cells on tissue function, and with the researchers» conclusion that «the observed improvements in skeletal muscle and fat of late - life treated 10 - month - old BubR1H / H; INK - ATTAC - 5 mice reflect attenuated progression of age - related declines rather than a reversal of ageing».

Interestingly, some of this variation seems to be driven by sex in skeletal muscle — a sexually dimorphic tissue — where a few maternally imprinted growth repressors have lower level of imprinting in females.

(6) In early - aging (2 - mo old) BubR1H / H; INK - ATTAC mice, but not young (3 - wk - old) mice, transcripts of the system and of reporter green fluorescent protein «were significantly elevated in [subcutaneous] adipose tissue, skeletal muscle and eye, but not in tissues in which endogenous p16Ink4a is not induced, including liver and heart.&raquIn early - aging (2 - mo old) BubR1H / H; INK - ATTAC mice, but not young (3 - wk - old) mice, transcripts of the system and of reporter green fluorescent protein «were significantly elevated in [subcutaneous] adipose tissue, skeletal muscle and eye, but not in tissues in which endogenous p16Ink4a is not induced, including liver and heart.&raquin [subcutaneous] adipose tissue, skeletal muscle and eye, but not in tissues in which endogenous p16Ink4a is not induced, including liver and heart.&raquin tissues in which endogenous p16Ink4a is not induced, including liver and heart.&raquin which endogenous p16Ink4a is not induced, including liver and heart.»

Rhabdomyosarcoma, the most common soft tissue cancer in children, was long thought to originate exclusively in early skeletal muscle cells.

Review: Gut Microbiota Contribute to Age - Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut - Muscle Axis — Gregory J. Grosicki — Calcified Tissue International

Ju YM, Atala A, Yoo JJ, et al., In situ regeneration of skeletal muscle tissue through host cell recruitment.

In brief, the affected tissues varied between animals, but inflammation was observed surrounding spinal cord, in the heart, skeletal muscle, and jointIn brief, the affected tissues varied between animals, but inflammation was observed surrounding spinal cord, in the heart, skeletal muscle, and jointin the heart, skeletal muscle, and joints.

Immunohistochemistry - Paraffin: Emx1 Antibody - Staining in human kidney and skeletal muscle tissues.

They also include the development of protocols to derive healthy skeletal cell types from patient - derived pluripotent stem cells and thereby to generate or regenerate healthy skeletal tissues in vivo.

Those fixed for histology, placed in tissue culture, and snap - frozen in OCT for cryosectioning included the heart, pericardium, bladder, knee and elbow joint tissues, skeletal muscle (bicep and quadriceps), dura mater, brain (cerebrum, cerebellum and brainstem), back skin, axillary and mesenteric lymph nodes, spleen, spinal cord and dorsal root ganglia, and peripheral nerves (sural, tibial, ulnar and median).

The Disease Biophysics Group has three open postdoctoral positions to be filled: 1) One position in skeletal muscle tissue engineering, 2) One position in cardiac muscle tissue engineering, and 3) One position in nanofibers and materials science (no biology background required).

Group research aims to study the relations between nutraceuticals, physical activity, intracellular mechanisms, gene expression and microbiota using a translational approach to characterize the impact in the whole body of metabolic interactions studied in individual organs and tissues (in vitro / ex vivo: skeletal muscle, heart, bone, liver and kidney).

In tissues — such as adipose tissue, skeletal muscle and eye — in which p16 (Ink4a) contributes to the acquisition of age - related pathologies, life - long removal of p16 (Ink4a)- expressing cells delayed onset of these phenotypeIn tissues — such as adipose tissue, skeletal muscle and eye — in which p16 (Ink4a) contributes to the acquisition of age - related pathologies, life - long removal of p16 (Ink4a)- expressing cells delayed onset of these phenotypein which p16 (Ink4a) contributes to the acquisition of age - related pathologies, life - long removal of p16 (Ink4a)- expressing cells delayed onset of these phenotypes.

The authors highlight the successful application of both induced pluripotent stem cells and embryonic stem cells for this first example of the in vitro formation of functional and mature skeletal muscle tissue, thereby also establishing the potential for patient - specificity in disease modeling, drug development, and possible muscle repair.

But in investigator - blinded comparisons of tissue sections from each group of mice, no evidence of defects related to loss of Wnt signaling were found in embryonic or adult pulmonary, renal, cerebral, or skeletal tissues.

Moreover, some tissues (for example, skeletal muscles and skin) will soon be easier to print or grow in a bioreactor than to mess with their cell therapy.

This is associated with modification of hypothalamic nitric oxide release that favors glucose uptake in metabolic tissues such as skeletal muscle, liver, and adipose tissue.

As much as we would want to have those skeletal muscles brimming with life till the fag end of our life, the harsh reality is that the wise 40s often signal the onset of Sarcopenia or a natural decline in the mass and tissue quality of the muscles.

Furthermore, continual aging endorses augmentation of non-contractile oxidised proteins which pile up in the skeletal muscle tissue and hinder muscle strength and its mass — all leading to poor muscle function.

On the other side, our insulin sensitivity has a natural circadian flow, which means that skeletal muscle is most sensitive in the morning and then experiences a gradual decline throughout the rest of the day, while fat tissue is the least sensitive in the morning.

BCAAs make up almost one - third of skeletal muscle tissue in humans, and leucine, isoleucine and valine are the three most important aminos for feeding hungry muscle.

As we already mentioned, adults have small amounts of brown fat, since it is the skeletal muscle tissue that is in charge of meeting the heat - producing requirements, which we already deemed brown fat's «first cousin».

Skeletal muscles contain thousands, sometimes millions of muscle fibers which are bundled together and contained in a layer of connective tissues.

Your bones» matrix is broken down during your daily activities, and, if you're healthy, collagen cells (the building blocks of bone tissue) are filled in to restore and strengthen our skeletal structure through a process called remodelling.