Sentences with phrase «in small clinical trial»

In this small clinical trial, cats will be treated with either daily oral omeprazole or placebo.

In a small clinical trial, astaxanthin supplementation itself (e.g. not in combination with omega - 3 from krill) was shown to improve immune function while decreasing inflammation (CRP) and lowering DNA damage.

That's what Ambrosia has been investigating, albeit in a small clinical trial that didn't have a control group.

The drug is in a small clinical trial in New Zealand due to end in April.

More formally, Dr. White and physician - researchers have begun testing the combination of morphine and a close relative of carbamazepine with patients in a small clinical trial at the Indiana University Melvin and Bren Simon Cancer Center.

A drug used for decades to treat high blood pressure and other conditions has shown promise in a small clinical trial for autism.

Or if used in a vaccine, they may be most effective in combination with other drugs: a few patients in the small clinical trials whose cancer relapsed after the trials responded to treatment with a checkpoint inhibitor.

Not exact matches

And it doesn't really do what it's supposed to: When Sprout conducted clinical trials, women only reported a small increase in the number of times they had satisfying sex — around one additional time per month.

As an exec at Shire (shpg), which with $ 6 billion in revenue is one of the smaller Big Pharmas, he spent months persuading leaders and commercial and supply - chain people to launch a clinical trial for the ADHD drug Vyvanse to treat binge eating.

While Yervoy brought in $ 960 million in sales in 2013 (an enormous figure for a two - year - old drug with a small patient population), the company currently has more than 35 ongoing clinical trials investigating another drug that disengages the immune system's brakes: the much - awaited nivolumab, which was also from the Medarex portfolio.

To achieve this goal, several approaches are envisaged: identifying small populations with severe disease where a medicine's benefit - risk balance could be favorable; making more use of real - world data where appropriate to support clinical trial data; and involving health technology assessment bodies early in development to increase the chance that medicines will be recommended for payment and ultimately covered by national healthcare systems.

In the randomized clinical trial, 230 adults with fibromyalgia received one of three treatments, each of which was presented for eight weekly sessions to small groups of patients.

Success with these models led to a small phase I clinical trial in which an individual's good bacteria with antimicrobial activity was grown, formulated in a skin cream and applied once to the forearm of the eczema patient infected by S. aureus.

Several other small companies, including Bentley Pharmaceuticals in Exeter, N.H., are conducting clinical trials on insulin nasal sprays as well.

Also in this issue, how single - person medical experiments, alternatives to big clinical trials, are leading to breakthroughs on a small scale.

The small trial was not randomized, double - blinded or placebo - controlled — the combination of which is considered the gold standard in clinical research.

Most Class III devices do require clinical testing, but the clinical trials are typically smaller, much less costly, and shorter in duration than those required for pharmaceuticals.

Researchers only discovered this process in the late 1990s, but they've already begun dozens of clinical trials to gauge whether infusing patients with these small RNAs works against a range of diseases, from lung infections to liver cancer to age - related macular degeneration, a sight - stealing condition that mainly affects people over the age of 50.

He's also likely to spur the FDA to follow the course laid out by agency cancer czar Richard Pazdur in speeding new approvals, possibly setting up a special unit aimed at orphan drugs to hasten OKs with smaller, better designed clinical trials.

Most clinical trials show that cutting out 1,000 milligrams of sodium from a diet, a relatively large amount, results in only a small drop in blood pressure on average, Cohen says.

On September 11, the company announced the completion of a small clinical trial of its adhesive: The sealant immediately stopped blood flow after an artery - clearing operation in about 85 percent of 22 participants.

An advantage of small - molecule PPF — which has been previously used in clinical trials in an attempt to treat Alzheimer's disease and dementia — is that it can penetrate the blood - brain barrier and reach the tumor.

However, what our trial has shown is that although this is still the case, the proportion of women who will actually have a recurrence without radiotherapy is very small (less than 5 percent), five years after treatment,» said Ian Kunkler, F.R.C.R., professor of clinical oncology at the Edinburgh Cancer Research Center in the University of Edinburgh.

This small molecule is in clinical trials against cancer and has high specificity and good pharmacological properties, which could warrant its further development as antiviral drug for treatment of pH1N1 virus infection,» Dr. Oxana Denisova says.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

Previous studies have shown that a small molecule known as ONC201 currently in advanced cancer clinical trials, targets self - renewing colorectal cancer stem cells.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative conditioIn a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative conditioin a mouse model of the neurodegenerative condition.

The spat involves a June 2001 paper in The American Journal of Psychiatry on a small clinical trial of the antidepressant Paxil that was funded by GlaxoSmithKline (GSK) and the National Institute of Mental Health.

Her research at Stanford University has contributed to the development of a small molecule peptide that is currently in Phase IIA clinical trials for AD.

The study, published in the July issue of the journal Epidemiology, offers benefits over typically used randomized clinical trials, as such studies are often too small to identify rare side effects or may be performed in a group of patients who do not take other types of medications or have other conditions that could skew the drug's effect in a broader group following approval.

Celiz agrees the danger is small but he says rigorous testing in lab animals and clinical trials should be done to rule out potential side effects.

«Although this was a small randomized trial, we believe it confirms that FMT from a rationally selected donor was safe and associated with substantial long - term improvements in both clinical and cognitive outcomes in patients with cirrhosis and recurrent HE», said Dr Bajaj.

What's particularly concerning is that these three medications displayed small or negligible effects in clinical trials that probably already inflated how well the drugs work, Ioannidis says.

In a small phase I and II clinical trial, Johns Hopkins researchers and colleagues elsewhere found that the high - fat, low - carbohydrate ketogenic diet was a safe and effective treatment option for the majority of adults experiencing a relatively rare, often fatal and always severe form of epilepsy marked by prolonged seizures that require medically induced comas to prevent them from further damaging the body and the brain.

In a small, phase I clinical trial, Johns Hopkins Kimmel Cancer Center researchers say they show for the first time that the experimental drug guadecitabine (SGI - 110) is safe in combination with the chemotherapy drug irinotecan and may overcome resistance to irinotecan in patients with metastatic colorectal canceIn a small, phase I clinical trial, Johns Hopkins Kimmel Cancer Center researchers say they show for the first time that the experimental drug guadecitabine (SGI - 110) is safe in combination with the chemotherapy drug irinotecan and may overcome resistance to irinotecan in patients with metastatic colorectal cancein combination with the chemotherapy drug irinotecan and may overcome resistance to irinotecan in patients with metastatic colorectal cancein patients with metastatic colorectal cancer.

This approach, however, differs from liquid biopsies, including commercial tests, which only profile a relatively small portion of the genome in patients already diagnosed with cancer for the purpose of helping monitor the disease or detect actionable alterations that can be matched to available drugs or clinical trials.

This new drug — AZD3965 — is currently in clinical trials, but it has not yet been tested in small cell lung cancer.»

In a small, single - center clinical trial, Chadwick Miller, M.D., M.S., and colleagues found that evaluating older, more complex patients in the observation unit with stress cardiac MRI, as opposed to usual inpatient care, reduced hospital readmissions, coronary revascularization procedures and the need for additional cardiac testinIn a small, single - center clinical trial, Chadwick Miller, M.D., M.S., and colleagues found that evaluating older, more complex patients in the observation unit with stress cardiac MRI, as opposed to usual inpatient care, reduced hospital readmissions, coronary revascularization procedures and the need for additional cardiac testinin the observation unit with stress cardiac MRI, as opposed to usual inpatient care, reduced hospital readmissions, coronary revascularization procedures and the need for additional cardiac testing.

«Epilepsy drug discovered in fish model shows promise in small pediatric clinical trial: Research suggests zebrafish models may be efficient resource for identifying drugs for clinical use.»

Women age 25 - 65 who have been diagnosed with HPV 16 or HPV 18 are needed to participate in a small Phase I tolerability clinical trial of GTL001 with only a three - month follow - up period.

However, despite this success, clinical trials using these antibodies caused inflammatory side effects in the brain of Alzheimer's patients, in particular amyloid - related imaging abnormalities (ARIA), which results in small bleeds and dangerous brain swelling.

Brian Madeux, the first patient in what will be a small clinical trial has a mild form of the disease, but nevertheless has had more than two dozen operations as a result, AP reports.

An early sign that this might be the case came from a small clinical trial testing a new drug that has been developed without a particular tumour type in mind.

Some research efforts are closer to clinical implementation, including developing improvements in clinical management of rare diseases and trials of small molecule therapies for inherited and mosaic genetic disorders.

«Lithium, long used in mental health as a highly effective mood stabiliser, has been on the radar as a potential disease modifying treatment for Alzheimer's disease with positive evidence from preclinical studies and a number of small clinical trials.

A randomized, phase II trial showed improved progression - free survival in small - cell lung cancer with maintenance sunitinib vs placebo following standard chemotherapy, according to results presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

Table 1: Selection, Design & Construction of HSV - based Oncolytic Viruses Table 2: Selection, Design & Construction of Adenovirus - based Oncolytic Viruses Table 3: Selection, Design & Construction of Vaccinia Virus - based Oncolytic Viruses Table 4: Selection, Design & Construction of Vesicular Stomatitis Virus - based Oncolytic Viruses Table 5: Selection, Design & Construction of Newcastle Disease Virus - based Oncolytic Viruses Table 6: Selection, Design & Construction of Various Virus - based Oncolytic Viruses Table 7: Current Company - Sponsored Clinical Trials of T - Vec Table 8: Clinical Trials of ColoAd1 Table 9: Clinical Trials with JX - 594 Table 10: Clinical Trials with GL - ONC1 Table 11: Clinical Trials of CAVATAK (CVA21) Table 12: Clinical Trials with MV - NIS Table 13: Overview of Oncolytic Viruses by Development Phase & Virus Family Table 14: Profile of Approved and Marketed Oncolytic Viruses Table 15: Pivotal Study Design of Oncolytic Viruses in Late Stage Development Based on Previous Clinical Results Table 16: Approved Indications of Immune Checkpoint Inhibitors Table 17: Active Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 18: Planned Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 19: Active or Planned Clinical Studies of Oncolytic Viruses in Combination with Other Anti-Cancer Therapeutics Table 20: Pattern of Transgenes in Oncolytic Viruses in Relation to Development Phase Tables 21a and 21b: Indications and Frquency and Way of Administration of Oncolytic Viruses in Active and / or Positive Completed Clinical Studies Table 22: Small and Medium Pharma & Biotech as Partner for Regional Co-Development of Oncolytic Viruses Table 23: Immuno - Oncology Portfolio of Major Pharma & Biotech with Interest in Oncolytic Viruses Table 24: Interests of Major Pharma & Biotech in Oncolytic Viruses Table 25: First Generation Oncology Virus Companies and their Sources of Technology Table 26: Second Generation Oncology Virus Companies and their Sources of Technology Table 27: Third Generation Oncology Virus Companies and their Sources of Technology Table 28: Fourth Generation Oncology Virus Companies and their Sources of Technology Table 29: Grants, Credits & Donations Table 30: Financing by Venture Capital, Private Equity and Other Private Placements Table 31: Collaboration & Licensing Agreements Table 32: Companies Listed on Stock Exchange & Offerings Table 33: Mergers & Acquisitions

Small, focused clinical trials are possible for certain B - cell malignancies such as Diffuse Large B - Cell Lymphoma in which patients can be stratified based on NF - kB activation status and / or presence of mutations known to activate NF - kB.

Immunologic checkpoint blockade with anti — cytotoxic T - lymphocyte — associated antigen 4 (CTLA - 4) or anti — programmed death 1 (PD - 1) / programmed death ligand 1 (PD - L1) agents seems to have some degree of clinical efficacy in advanced mucosal melanoma, although data are limited to smaller retrospective series or subset analyses of prospective trials.

Clinical benefits of lentiviral vectors have been observed in small trials for other diseases, including the common hematopoietic disorders