Sentences with phrase «in stem cell survival»

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The authors of the study say that improvements in management, multi-drug chemotherapy, immunotherapies, stem cell transplants, radiotherapy and treatments that have less toxic side - effects have all contributed to the improvement in survival from leukemia.

The investigators report that trapping virus - loaded stem cells in a gel and applying them to tumors significantly improved survival in mice with glioblastoma multiforme, the most common brain tumor in human adults and also the most difficult to treat.

However, as has been discovered by a team of Frankfurt - based researchers, these cells do have a weakness: In the current edition of the high impact journal «Cancer Research,» they report that the enzyme 5 - lipoxygenase (5 - LO) plays a significant role in the survival of leukaemic AML stem cellIn the current edition of the high impact journal «Cancer Research,» they report that the enzyme 5 - lipoxygenase (5 - LO) plays a significant role in the survival of leukaemic AML stem cellin the survival of leukaemic AML stem cells.

Under experimental conditions, the researchers then demonstrated that elevated levels of elastase dramatically reduce the survival and operation of muscle stem cells in culture.

Using the same computer - based approach, the team has now been able to target the c - FLIP (cellular FLICE [FADD - like IL - 1β - converting enzyme]- inhibitory) protein, known to play a key role in cancer stem cell maintenance and survival, described in previously published work by the Institute.

The study, «Lenalidomide (LEN) maintenance (MNTC) after high - dose melphalan and autologous stem cell transplant (ASCT) in multiple myeloma (MM): A meta - analysis (MA) of overall survival (OS),» is ASCO 2016 abstract no. 8001 and will be discussed during the Hematologic Malignancies — Plasma Cell Dyscrasia oral abstract session Friday, Juncell transplant (ASCT) in multiple myeloma (MM): A meta - analysis (MA) of overall survival (OS),» is ASCO 2016 abstract no. 8001 and will be discussed during the Hematologic Malignancies — Plasma Cell Dyscrasia oral abstract session Friday, JunCell Dyscrasia oral abstract session Friday, June 3.

By tinkering with the medium in which cells are grown, researchers at the Salk Institute for Biological Studies created a type of stem cell with a survival rate of 30 to 40 percent, vs. 1 percent.

When optimal temperatures are restored, the plant stem cells can divide at a faster rate, which will in turn enhance recovery and survival of the plant.»

A study published January 4th in Cell Stem Cell demonstrates that a gene therapy approach can lead to the long - term survival of functional beta cells as well as normal blood glucose levels for an extended period of time in mice with diabetes.

In a study recently published in the journal Cytotherapy, researchers in India discovered that treating mice with a common anti-inflammatory drug called celecoxib promoted stem cell survival and healing when they injected the cells into woundIn a study recently published in the journal Cytotherapy, researchers in India discovered that treating mice with a common anti-inflammatory drug called celecoxib promoted stem cell survival and healing when they injected the cells into woundin the journal Cytotherapy, researchers in India discovered that treating mice with a common anti-inflammatory drug called celecoxib promoted stem cell survival and healing when they injected the cells into woundin India discovered that treating mice with a common anti-inflammatory drug called celecoxib promoted stem cell survival and healing when they injected the cells into wounds.

«Reducing inflammation protects stem cells during wound repair: Anti-inflammatory drug Celecoxib can promote stem cell survival and wound healing in mice.»

In order to learn more about how celecoxib was enhancing stem cell survival and wound healing, the researchers conducted experiments to identify the cytokines or enzymes directly or indirectly influencing the process.

She also noted the targeting Msi in primary tumors significantly changed «the trajectory of progression by halting pancreatic cancer growth and improving survival,» inhibiting both cancer stem cells and other tumor cells.

In their report published in Cancer Immunology Research, a team from the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital (MGH) describes how adding AMD3100 (plerixafor)-- previously approved for the stimulation of stem cell production prior to bone marrow transplantation — to their investigational drug VIC - 008 more than doubled the animals» survival timIn their report published in Cancer Immunology Research, a team from the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital (MGH) describes how adding AMD3100 (plerixafor)-- previously approved for the stimulation of stem cell production prior to bone marrow transplantation — to their investigational drug VIC - 008 more than doubled the animals» survival timin Cancer Immunology Research, a team from the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital (MGH) describes how adding AMD3100 (plerixafor)-- previously approved for the stimulation of stem cell production prior to bone marrow transplantation — to their investigational drug VIC - 008 more than doubled the animals» survival time.

«These findings suggest that BES may thus be used as a strategy to improve cell survival and prevent cell apoptosis in stem cell - based transplantation therapies,» Fan explained.

Currently, PBSCs are the major stem cell source, owing to faster engraftment and ease of collection despite a higher rate of graft - vs - host disease and lower survival rates in patients with nonmalignant disorders.

«One of the bottlenecks with stem cell therapy is the survival of cells once they're put in the body — about 80 to 90 percent of them often appear to die,» says Jeff Bulte, Ph.D., a professor in the Johns Hopkins University School of Medicine's Institute for Cell Engineercell therapy is the survival of cells once they're put in the body — about 80 to 90 percent of them often appear to die,» says Jeff Bulte, Ph.D., a professor in the Johns Hopkins University School of Medicine's Institute for Cell EngineerCell Engineering.

Using induced pluripotent stem cells (iPSCs), a team led by Mount Sinai researchers has gained new insight into genetic changes that may turn a well known anti-cancer signaling gene into a driver of risk for bone cancers, where the survival rate has not improved in 40 years despite treatment advances.

Conditional survival and excess mortality after high - dose therapy with autologous stem cell transplantation for adult refractory or relapsed Hodgkin lymphoma in Norway.

Stem cell biologist Young - sup Yoon and colleagues recently published a paper in Biomaterials in which the authors use chitosan, a gel - like carbohydrate material obtained by processing crustacean shells, to aid in cell retention and survival.

Researchers have discovered that inducing quiescence in stem cells may be an effective means to enhance stem cell survival

My last question is if you could speak to the survival rates due to stem cell transplants in the last ten years, given the associated risk factors with transplants such as GVHD.

In Vivo Monitoring of Survival and Proliferation of Hair Stem Cells in a Hair Follicle Generation Animal ModIn Vivo Monitoring of Survival and Proliferation of Hair Stem Cells in a Hair Follicle Generation Animal Modin a Hair Follicle Generation Animal Model

Bone morphogenetic protein signaling is involved in human mesenchymal stem cell survival in serum - free medium.

In prior studies, scientists had difficulty with maintaining the survival of stem cell - derived liver cells once transplanted into existing liver tissue.

We report the presence of cancer stem cell like Side Population and their survival and enrichment post treatment with bleomycin in HCT116 cell line.

Our pioneering work has resulted in one of the largest bone marrow and stem cell transplant programs in the world, with unparalleled survival rates.

We have observed significantly better graft and patient survival in stem cell group vs. controls with additional benefits of minimization of immunosuppression.

Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo.

One promising solution to increase long - term overall survival has been in the area of allogeneic hematopoietic stem cell transplantation (HCST).

Dr. Tajonar obtained her PhD in the laboratory of Prof. Douglas Melton at Harvard University in 2012 where she studied mechanisms of self - renewal and survival in human embryonic stem cells.

ASCs isolated from the stromal vascular fraction of fat have advantages over other mesenchymal stem cell sources; they are easy to isolate and expand and aid in the repair of damaged tissues [7], including islet graft survival and revascularization [8].

The major gains in behavioral recovery and neuronal survival achieved by pre-differentiation of glial precursors to specific, beneficial astrocytic cell types prior to transplantation stresses the need to consider such manipulations as a critical component in the optimization of stem / precursor cell transplantation based therapies.

No Association Between Response Rates and Survival in Newly Diagnosed Multiple Myeloma: Results of a recent meta - regression analysis of 63 randomized clinical trials out of Greece concluded that there was no association between conventional response outcomes, such as complete response (CR) or very good partial response (VGPR), and overall (OS) or progression - free survival (PFS) in patients with newly diagnosed multiple myeloma in populations of patients who received stem cell transplant and those who Survival in Newly Diagnosed Multiple Myeloma: Results of a recent meta - regression analysis of 63 randomized clinical trials out of Greece concluded that there was no association between conventional response outcomes, such as complete response (CR) or very good partial response (VGPR), and overall (OS) or progression - free survival (PFS) in patients with newly diagnosed multiple myeloma in populations of patients who received stem cell transplant and those who survival (PFS) in patients with newly diagnosed multiple myeloma in populations of patients who received stem cell transplant and those who did not.

CRP Levels Before Transplant Linked With Survival in Multiple Myeloma: According to a new study, patients with an elevation in C - reactive protein (CRP) prior to an autologous stem cell transplantation (ASCT) for multiple myeloma experienced a worse overall survival (OSurvival in Multiple Myeloma: According to a new study, patients with an elevation in C - reactive protein (CRP) prior to an autologous stem cell transplantation (ASCT) for multiple myeloma experienced a worse overall survival (Osurvival (OS) rate.

Results from a recent trial of this technique in a SCID disorder show 100 % survival rates at 7 years post-treatment, xvi compared with 85 % survival in patients receiving a stem cell transplant from a healthy sibling.

Ponatinib Extends Survival Over Transplant in Chronic Phase CML: The results of a new study that included patients from the PACE trial and the European Bone Marrow Transplant registry revealed that treatment with ponatinib yielded better overall survival (OS) compared with allogeneic stem cell transplantation (allo - SCT) in patients with chronic phase chronic myeloid leukemia (CP - CML) with a T315I mSurvival Over Transplant in Chronic Phase CML: The results of a new study that included patients from the PACE trial and the European Bone Marrow Transplant registry revealed that treatment with ponatinib yielded better overall survival (OS) compared with allogeneic stem cell transplantation (allo - SCT) in patients with chronic phase chronic myeloid leukemia (CP - CML) with a T315I msurvival (OS) compared with allogeneic stem cell transplantation (allo - SCT) in patients with chronic phase chronic myeloid leukemia (CP - CML) with a T315I mutation.

Prior to QB3, she studied mechanisms of self - renewal and survival in human embryonic stem cells in the laboratory of Professor Douglas Melton, completing her PhD at Harvard University in 2012.

His laboratory at Stanford University School of Medicine is developing novel stem cell and nanotherapeutics approaches for ocular repair, studying retinal ganglion cell development, survival and axon regeneration in glaucoma, and investigating the cellular basis for the developmental loss of axon growth ability.

Acute myeloid leukemia (AML) is the leading cause of leukemia mortality in the United States.1 Curative treatment involves intensive induction chemotherapy, before proceeding to either consolidation chemotherapy or allogeneic stem cell transplantation based on the patient's risk for relapse.2 This approach has been employed for > 4 decades and, although most individuals achieve complete remissions with front - line therapy, 3 the majority of patients ultimately relapse with drug - resistant disease, and overall survival rates remain disappointingly poor.4 The limited ability of many patients to tolerate the intense chemotherapy - based treatments, in particular hematological toxicity, further contributes to the poor outcomes noted in this disease.

In addition to showing no survival difference between transplant recipients who received bone marrow or peripheral stem cells, the study showed no difference in relapse rates, mortality unrelated to relapse or rate of acute GVHIn addition to showing no survival difference between transplant recipients who received bone marrow or peripheral stem cells, the study showed no difference in relapse rates, mortality unrelated to relapse or rate of acute GVHin relapse rates, mortality unrelated to relapse or rate of acute GVHD.

We see from human medicine that peripheral blood stem cell transplantation, in conjunction with chemotherapy, has raised human survival rates considerably.»

«It regulates cancer stem cells... the ones that allows the cancer to grow... And it plays a really prominent role in the survival of cells.»