Questions remain concerning why neurons that apparently express similar innexins (the different motor neuron classes) rarely form gap junctions with one another, if gap junctions are subject to constant formation and reformation in the nervous system, and why there appears to be a consistency
in subcellular localization (soma versus process) of certain gap junctions.
Phosphorylation of tumor necrosis factor receptor CD120a (p55) by p42 mapk / erk2 induces changes
in its subcellular localization.
Thus, a change
in the subcellular localization of CED - 4 may drive programmed cell death.
Not exact matches
A high - resolution map of the human cell has been generated — part of the Human Protein Atlas database — that provides the
in situ
localization of 12,036 human proteins at a single - cell level, covering 30
subcellular structures, and enabling 14 major organelle proteomes to be defined.
Her research is at the interface between bioimaging and proteomics, and aims to define the spatiotemporal organization of the human proteome at a
subcellular level
in an effort to understand how variations and deviations
in localization contribute to cellular function as well as disease.
We demonstrated the technique on 20 different biological processes spanning four orders of magnitude
in space and time, including the binding kinetics of single Sox2 transcription factor molecules, 3D superresolution photoactivated
localization microscopy of nuclear lamins, dynamic organelle rearrangements and 3D tracking of microtubule plus ends during mitosis, neutrophil motility
in a collagen mesh, and
subcellular protein
localization and dynamics during embryogenesis
in Caenorhabditis elegans and Drosophila melanogaster.
Open Reading Frame E3 - 10.9 K of Subspecies B1 Human Adenoviruses Encodes a Family of Late Orthologous Proteins That Vary
in Their Predicted Structural Features and
Subcellular Localization.
Sina Koch (Ehninger, TUD)-- «Aberrant
subcellular localization as a potential mechanism contributing to the abnormal signaling of the mutant Flt3 - ITd receptor tyrosine kinase
in acute myeloid leukemia» (2007)
The researchers also examined the
subcellular localization of ApoE proteins
in human neuroblastoma cells transfected with either ApoE3 or ApoE4, detecting the molecules
in both the cytoplasm and the nucleus.
Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of
subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.
Additionally, an alteration of
subcellular localization from nuclei to cytoplasm was also observed
in > 70 % of cutaneous squamous cell carcinoma samples.
A and B, phosphorylation and
subcellular localization of mTOR signaling proteins
in ALCL cell lines.
Our results clearly indicate that the expression of DDX3 is decreased
in HCC and the
subcellular localization of DDX3 is altered
in cutaneous SCC (see Figs. 5 and 6).
The expression or
subcellular localization of DDX3 is altered
in tumor cells.
In the second step, all antibodies targeting the same protein are taken in consideration for final annotation of the subcellular localizatio
In the second step, all antibodies targeting the same protein are taken
in consideration for final annotation of the subcellular localizatio
in consideration for final annotation of the
subcellular localization.
Distribution and
subcellular localization of glucocorticoid receptor immunoreactive neurons
in the developing and adult male zebra finch brain.
In the PROSPECTS project new or improved tools and approaches have been developed to enable absolute protein quantification, study of protein - protein interactions and protein complexes and the quantitative study of protein abundance and turnover rates in different subcellular localizations at a proteome - wide leve
In the PROSPECTS project new or improved tools and approaches have been developed to enable absolute protein quantification, study of protein - protein interactions and protein complexes and the quantitative study of protein abundance and turnover rates
in different subcellular localizations at a proteome - wide leve
in different
subcellular localizations at a proteome - wide level.
Interferon regulatory factor
subcellular localization is determined by a bipartite nuclear
localization signal
in the DNA - binding domain and interaction with cytoplasmic retention factors
Several highly conserved residues
in SERT have been shown to be critical for its
subcellular localization, and mutation of these sites may contribute to both obsessive - compulsive disorder (OCD) and autism.
The cellular
localization of the polymers was confirmed by
subcellular fractionation of the cells, followed by digestion with endoglycosidase H (Figure 2C and Supplemental Figure 3C), an enzyme that removes N - linked glycans still
in the high mannose ER form but does not affect oligosaccharide chains after the addition of sialic acid
in the Golgi apparatus.
METHODS: We treated 3T3 - L1 adipocytes with 2.5 mmol / l R (+) alpha - lipoic acid for 2 to 60 min, followed by assays of: 2 - deoxyglucose uptake; glucose transporter 1 and 4 (GLUT1 and GLUT4)
subcellular localization; tyrosine phosphorylation of the insulin receptor or of the insulin receptor substrate - 1
in cell lysates; association of phosphatidylinositol 3 - kinase activity with immunoprecipitates of proteins containing phosphotyrosine or of insulin receptor substrate - 1 using a
in vitro kinase assay; association of the p85 subunit of phosphatidylinositol 3 - kinase with phosphotyrosine proteins or with insulin receptor substrate - 1; and
in vitro activity of immunoprecipitated Akt1.