Sentences with phrase «in switching genes»

(The team doesn't yet understand why, because the changed base pair lies in a region that is not translated into RNA and is not usually involved in switching genes on and off.)

With chronically infected mice as their model, the researchers used a new technology called ATAC - seq to map the regulatory regions of the genome — the sections of DNA involved in switching genes on and off — in the animals» exhausted and functional CD8 + T cells.

Not exact matches

Another process called epigenetics that switches genes on and off may explain why ho - mose - xuality runs in families.

Our gee show that micro changes in our epigenetics can turn on and off genes or have them exhibit themselves in different ways and with enough flipping of the micro switches you can get some pretty impressive macro changes in relatively short periods of time.

As differentiation continues, various genes are «switched off» but stem cells, even in adults, retain a certain pluripotency in order to produce fully differentiated cells lost by damage or ageing.

Davies and Lineweaver suggest that genes active in embryogenesis and switched off later may be reactivated because of damage, causing the accelerated cell division of these rogue cancer cells.

Vocabularies proliferate as repressor genes, corepressors and aporepressors, modifier and switch genes, operator genes that activate other genes, cistrons and operons that constitute subsystems of interacting genes — even genes that regulate the rate of mutation in other genes — are invoked.

How the appropriate genes are switched on in appropriate places remains a problem.

However, different genes are switched on in different environments.

Gene, Gene the Coke Machine (that's Coke as in soda pop) is the team's moniker for the 6» 3», 280 - pound Chilton, who's being switched from tackle to center, where he'll anchor an offensive line that lost four of five starters, not counting both tight ends.

They discovered an orchestrated switching on and off of various genes as the mammary gland transitions from secreting small amounts of immunity - boosting colostrum in the first days after giving birth to the copious production of milk in mature lactation.

«Cancer cells disguise themselves by switching off genes, new research reveals: A genome - wide map of the genes switched off in aggressive tumors reveals a «signature».»

The tag H3K27me3 (shown in green), can switch gene activity off.

In a study published in Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a «signature» of these switches throughout the genomIn a study published in Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a «signature» of these switches throughout the genomin Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a «signature» of these switches throughout the genomin different parts of the tumor, providing a «signature» of these switches throughout the genome.

Nathaniel Hoyle of the MRC Laboratory of Molecular Biology in Cambridge, UK, and his colleagues have discovered that genes in a type of skin cell switch on and off during day - night cycles.

«Regulatory RNA modules are attractive for applications in synthetic biology, because they detect signals from the environment directly and instantly switch the subsequent genes on or off,» explains Johanna Roßmanith.

Tsai's group manipulated the gene for the protein p25, which has been implicated in several neurodegenerative diseases, so that it could be easily switched on and off.

Within individual SCN cells, specialized clock genes are switched on and off by the proteins they encode in a feedback loop that has a 24 - hour rhythm.

The study, published online today in Science Translational Medicine, further points to a master switch for these gene sets as a potential target of future therapies.

This action can result in the activation of genes that had been switched off, and could be the cause of the recovery of synaptic strength.

Porcar's team engineered gene switches in Escherichia coli to produce proteins that emit different coloured fluorescent light when factors such as heat, acidity and oxygen levels change.

Biologists are studying whether genes could be switched on and off in plants depending on climatic conditions

The key insight for building such drugs came to Tim Tully, founder and chief science officer of Helicon, when his team at Cold Spring Harbor Laboratory on Long Island stumbled upon the molecular switch: a gene called CREB, which is involved in converting short - term memories into long - term ones.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

These epigenetic switches and markers in turn help switch on or off the expression of particular genes.

Working with this hypothesis, the researchers conducted a statistical analysis of the CX3CR1 gene in over 7000 schizophrenia and autism patients and healthy subjects, finding one mutant candidate, a single amino acid switch from alanine to threonine, as a candidate marker for prediction.

But after months of painstaking research they had at last succeeded in switching off the gene and getting rid of the glow.

CBX2 has aroused interest as a possible master switch for maleness because tests in human cells suggest that mutations in it can shut off a gene on the Y chromosome critical for male sexual development.

Nadeau has discovered that in the Fresno children, long - term exposure to air pollution and secondhand smoke switched off two specific genes.

More recently, it has become clear that slight variations in the regulatory sequences that determine when a gene is switched on,...

The only trouble was that the Nasmyth lab was devoted entirely to the study of the HO gene (involved in mating - type switching) in the budding yeast Saccharomyces cerevisiae.

«The IMM teams showed clearly that the gene was switched on only in hypoxic regions,» says Sue Kingsman, the research director of Oxford BioMedica.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

Harris and Ratcliffe describe in this month's Nature Genetics (vol 2, p 515) how the switch system might be used in gene therapy for cancers.

The system has the potential to add, change or switch off thousands of genes at a time — Church calls this «multiplexing» — and it can generate billions of new strains in days.

The new gene permanently switched on a set of genes normally affected by insulin and involved in the immune system.

These compounds, in turn, switch on the genes that enable the bacteria to colonize the gut wall and to exude their toxin.

Nadeau stumbled upon one study, in mice, describing how environmental factors can tag Foxp3 with chemical markers that tell T - cell precursors to switch the gene on or off.

Harris and Peter Ratcliffe, also at the IMM, discovered the genetic switches, which they call «hypoxia - responsive elements» (HREs), in segments of DNA known as regulatory genes.

To determine the effect of mutations that reduce TET2 function in abnormal stem cells, the research team genetically engineered mice such that the scientists could switch the TET2 gene on or off.

«Same switches program taste, smell in fruit flies: Findings help explain how complex nervous systems arise from few genes.»

The methyl groups that switch genes on and off are not made by the body, instead we get them by eating foods rich in nutrients such as choline and folate, which are found in raw liver and cruciferous vegetables like cabbage and broccoli.

All cells contain the same DNA, but individual genes in any cell can be switched on or off by the addition or subtraction of a methyl group — a carbon atom bound to three hydrogen atoms.

In these animals, they switched off the gene responsible for producing the enzyme arylsulfatase G.

Gene switches have been identified that work in specific brain areas, potentially enabling targeted treatment of unhealthy cells.

In cancer, these switches inappropriately activate or silence important genes, such as those that regulate cell growth and life cycle, ultimately leading to tumors.

Since beginning a lab dedicated to understanding cancer metastasis at Rockefeller six years ago, Associate Professor Sohail Tavazoie has found that microRNAs — tiny strands of RNA that function as switches to inactivate specific genes — play an important role in controlling genes linked to metastasis.

«Switching off a gene is of course feasible, the issue is whether it will have the desired effect and whether it's the right thing to do... But in terms of trying to develop a therapy to delay or prevent hair graying, that is something that is potentially feasible; yes.»

Calcium ions then travel through the channel, switching on a synthetic piece of DNA the scientists developed to turn on the production of a downstream gene, which in this study was the insulin gene.

Epigenetic therapies are thought to work in two ways to fix these errors in cancer cells — by correcting the «position» of the gene switches and by making the cell appear as though it's infected by a virus, triggering the immune system.