Sentences with phrase «in synaptic dysfunction»

Differences in synaptic dysfunction between rTg4510 and APP / PS1 mouse models of Alzheimer's disease S GELMAN, J PALMA, P KABITZKE, G TOMBAUGH, A GHAVAMI... Abstract / Posters

In an earlier study published in Nature Medicine, an international team of scientists discovered that the additional copy of chromosome 21 in Down's syndrome reduces the production of SNX27 in the brain and results in synaptic dysfunction.

Not exact matches

The protein's role in the pathway leading to memory impairment, however, remained unclear until scientists from IMCB utilised live - cell imaging techniques to elucidate the mechanism of memory impairment and illustrated how SNX27 attributes to synaptic dysfunction.

Like humans with AD, hAPP mice have elevated levels of amyloid β (Aβ) peptides in the brain, network and synaptic dysfunction, and amyloid plaques (9).

In principle, these homeostatic mechanisms could be harnessed to counteract cognitive decline and synaptic dysfunction in aging nervous systemIn principle, these homeostatic mechanisms could be harnessed to counteract cognitive decline and synaptic dysfunction in aging nervous systemin aging nervous systems.

Alzheimer's disease (AD) is characterized by deposition of amyloid - β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration.

Our purpose is to better understand synapthopathies in general with a special focus on synaptic dysfunction induced by autoantibodies.

The goal of our research is to better understand the cellular and molecular mechanisms involved in neuronal and synaptic dysfunctions characterizing neuropsychiatric diseases.

Published on April 20 in the journal Molecular Psychiatry, this work reveals that the loss of function of this gene involved in intellectual disability and autism, leads to synaptic dysfunction.

Host: Dr. Miriam Spering Speaker: Dr. Lynn Raymond, UBC Title: Synaptic dysfunction in prodromal Huntington disease

Francesco Longo is interested in understanding the synaptic and behavioral abnormalities associated with autism spectrum disorder, with particular attention to striatal dysfunction in fragile X syndrome model mice.

Cellular and molecular basis of synaptic dysfunction and aberrant behavior in autism, tuberous sclerosis complex, and Angelman syndrome

Santini, E., Turner, K.L., Ramaraj, A.B., Klann, E. *, and Kaphzan, H. * (2015) Mitochondrial superoxide contributes to hippocampal synaptic dysfunction and memory deficits in Angelman syndrome model mice.

Additionally, synaptic dysfunction is evident in early development of pathology.

Notably, we have found that prolonged activation of these pathways results in altered translational control, which contributes to synaptic dysfunction and memory deficits in AD model mice.

Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as cognitive deficits [2, 3].

We believe that this 10 - lipid phospholipid biomarker panel reflects the breakdown of neural cell membranes in those individuals destined to develop advanced moderate cognitive impairment or Alzheimer's disease and may mark the transition between preclinical states where synaptic dysfunction and early neurodegeneration give rise to subtle cognitive changes.»