Haghighi studies synaptic growth, function and plasticity in both normal and diseased animals, aiming to identify the very earliest
malfunctions in synaptic function.
[55] More recent work showed, that DBS upregulates genes
involved in synaptic function, cell survival, and neurogenesis [56], making some first steps at explaining the restoration of hippocampal circuit function.
Wei - Chi She, Charles Quairiaux, Michael J. Albright, Yu - Chi Wang, Denisse E. Sanchez, Poh - Shing Chang, Egbert Welker, Hui - Chen Lu (2009) «Roles of
mGluR5 in synaptic function and plasticity of the mouse thalamocortical pathway», European J. Neuroscience, 29: 1379 — 1396 (EJN featured article).
However, Littleton and Cho demonstrated that acute
changes in synaptic function could also lead to synaptic structural plasticity during development.
NMDA - Rs are expressed in both neurons and glia (Conti et al., 1997; Verkhratsky and Kirchhoff, 2007), and selective genetic access to these cell classes in the brain could allow for dissection of their relative
role in synaptic function.
Dr. Klann's research is focused on the molecular mechanisms of translational control and their role in activity - dependent changes
in synaptic function and behavior, including cognition.
It has been proven to promote positive changes
in synaptic functioning.