Sentences with phrase «in synaptic strength»

The possibility that membrane fusion events in the postsynaptic cell may be required for the change in synaptic strength resulting from long - term potentiation (LTP) was examined.

Much of the current work in the lab is focused on how activity controls this receptor trafficking and how the increase in synaptic strength during LTP is stabilized and maintained.

These properties, which are believed to be important for the induction of long - term changes in synaptic strength, are imparted by asparagine residues in a putative channel - forming segment of the protein, transmembrane 2 (TM2).

Learning and memory are widely believed to result from changes in synaptic strength.

With the combined use of genetics and pharmacology, the investigators altered the production of proteins controlled by eIF2α in adult mice, essentially converting them into adolescents by making them more susceptible to cocaine - induced changes in synaptic strength and behavior.

Changes in synaptic strength and in spine properties have long been associated with learning and memory, according to Alcino Silva, director of the Integrative Center for Learning and Memory at the University of California at Los Angeles.

We use a number of experimental approaches to gain a greater understanding of translational control mechanisms necessary for maintaining long - lasting changes in synaptic strength and memory.

The researchers» next step is to study the channel and transporter - like properties of VGLUT1 and its related isoform in greater detail, to see if they contributes to changes in synaptic strength that underlie learning, memory and many other aspects of cognition.

«It's all fitting with the overriding idea that changes in synaptic strength are part of the way these drugs motivate behavior in a persistent way,» McGehee said.