Sentences with phrase «in synthetic lethality»
We have shown that the loss of function of the PI5P4K enzymes results in synthetic lethality with p53 loss.
https://www.sbpdiscovery.org/ Not exact matches
«Dr. Hambleton's unique clinical background in both immuno - oncology and synthetic lethality will strengthen our organization's capabilities as we advance multiple first - in - class programs into the clinic, leveraging our clinical strategy in patient selection and combinations.»
«We are pleased to share this vision with the unique blend of crossover funds, pharmaceutical companies, and venture capital investors participating in our Series B, and look forward to advancing our position as the leading biotech with a dual focus on synthetic lethality and immuno - oncology.»
Synthetic lethality has become a therapeutic reality with the regulatory approval of PARP inhibitors in BRCA - deficient cancers.
Synthetic lethality - based strategy has been developed to identify therapeutic targets in cancer harboring tumor suppressor gene mutations, as exemplified by the effectiveness of PARP inhibitors in BRCA1 / 2 - mutated tumors.
Defective HR is an important therapeutic target in EOC as exemplified by the efficacy of platinum analogues in this disease, as well as the advent of PARP inhibitors, which exhibit synthetic lethality when applied to HR - deficient cells.
Their contributions to the yeast community include physical mapping methods, synthetic lethality screen approaches for identifying cross-species candidate genes as potential cancer drug targets, and a widely used set of vectors and yeast host strains that have been instrumental in work that has led to countless discoveries in recent decades.
Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug - resistant chronic myeloid leukemia
3) Unni A *, †, Lockwood WW *, †, Zejnullahu K, Lee - Lin S, Varmus H (2015) Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma.
, Lee - Lin S, Varmus H (2015) Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma.