Sentences with phrase «in systems biology approaches»

The resulting data are being combined in a systems biology approach with high - resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models to identify disease - associated genetic variants, disease - defining molecular signatures, and potential targets for therapeutic intervention.

Not exact matches

It is a problem that holistic approaches to biology such as general systems theory have been most interested in, and it is the problem that prompted C. Lloyd Morgan to speculate about forms of relatedness.

Since the completion of the Human Genome Project in 2003, scientists have expanded their knowledge of how living cells work with new approaches including genomics, proteomics, and systems biology.

A biologist, Schaal was among the first plant scientists to use molecular biology - based approaches to understand evolutionary processes in plants and she has worked to advance understanding of plants» molecular systems and population genetics.

In the research community, we've got to develop systems biology approaches, such as this one, that take a more sophisticated approach to get us where we need to be.»

There are ongoing studies which focus on the discovery of molecular biomarkers of the VSV - ZEBOV vaccine in healthy individuals using omics - based technologies in combination with a systems biology approach,» says Ali Harandi.

In Europe, the Center for Research and Interdisciplinarity (CRI), for example, offers a 2 - year Interdisciplinary Approaches in Life Sciences master's program with a specific track in systems and synthetic biologIn Europe, the Center for Research and Interdisciplinarity (CRI), for example, offers a 2 - year Interdisciplinary Approaches in Life Sciences master's program with a specific track in systems and synthetic biologin Life Sciences master's program with a specific track in systems and synthetic biologin systems and synthetic biology.

The approach combined experimental synthetic biology led by Mark Isalan, now Reader in Gene Network Engineering at the Department of Life Sciences of Imperial College London with computational modelling led by James Sharpe, ICREA Research Professor and head of the Multicellular Systems Biology lab at the CRG.

By using a systems biology approach, researchers deliberately move away from the classic reductionist manner of looking at molecules in isolation to study biological systems in their entirety.

-- In silico basic and systems biology: We develop innovative approaches to reverse engineer biological networks from omics data, model tumor progression at the genomic, transcriptomic and epigenetic level, automatically annotate new proteins and functional elements through integration of complex and heterogeneous data, including data obtained from high - throughput sequencing or time - lapse video - microscopy.

The Transcriptomics Core Facility supports a systems biology approach in vaccine development focusing on the identification of transcriptomic correlates of vaccine immunogenicity and efficacy for a range of novel and licensed vaccines using PBMC or whole - blood and BAL fluid samples.

It uses cutting edge approaches to understand entire systems involved in complex biology, from a cell to the central nervous system.

The ERA - Net ERACoSysMed, collaboration on systems medicine funding to promote the implementation of systems biology approaches in clinical research and medical practice, started in January 2015 as the first ERA - Net on systems medicine under the EU Framework Programme Horizon 2020.

The Bergthaler laboratory pursues an integrative approach comprising infection models and tools of immunology, pathology and systems biology in order to dissect novel disease - relevant interactions between pathogens and the host.

Development of a gene expression assay in non-human primates: We will develop a novel sensitive assay for the characterisation of vaccination - related gene expression profiles in NHPs, using an approach that is fully harmonised with the systems biology platform.

Using synthetic biology approaches, I am engineering fluorescent organisms to monitor mechanical sensing systems in response to pressure.

Since biological systems challenge the available methods, and the necessary foundations in physics, computer science, and mathematics are often missing, the CellDevo track greatly benefits from the fundamental research in computer science, bio-image informatics, biophysics, and applied mathematics represented in the CompBio and BioPhysEng tracks and help to develop the methodological foundations for future biology in tight integration with life imaging and other experimental approaches.

The research, published in the Proceedings of the National Academy of Sciences in September 2017, uses a combination of real - world bacterial culture results and medical records from nursing home patients, and a computing approach known as systems biology.

Dissecting these interactions with a combination of cell - biology and systems biology approaches should allow uncovering the tissue specific control mechanisms that are defective in cancer.

Systems biology is an approach to biomedical research in which scientists combine complex «omics» datasets to develop a more complete understanding of complex biological systems, such as the regulation of whole genome - level transcription, regulation of the 3D genome, the role of signaling and metabolic pathways in disease, anSystems biology is an approach to biomedical research in which scientists combine complex «omics» datasets to develop a more complete understanding of complex biological systems, such as the regulation of whole genome - level transcription, regulation of the 3D genome, the role of signaling and metabolic pathways in disease, ansystems, such as the regulation of whole genome - level transcription, regulation of the 3D genome, the role of signaling and metabolic pathways in disease, and more.

Approaches successful in other systems, such as modeling signal transduction and synthetic biology methodologies [32] could improve future generations of detector plants by enhancing signal transmission and providing means to deal with biological «noise».

An in vivo - vitro shuttle system for the study of P. cynomolgi liver stages12 is being exploited to better understand hypnozoite biology using molecular tools and genome - scale approaches, which rely on the availability of a complete and well annotated P. cynomolgi reference genome sequence.

Integrated systems biology approaches can identify gene regulatory networks, such as immune, stress and other regulatory responses, and link them with physiologic states.6 This bioinformatics approach provides an unbiased view of the immune system profile, and can be linked to changes in environmental conditions.7 These network approaches, while often applied to identifying disease profiles, can be used to identify salutary states as well, such as that which might result from intensive meditation.

In addition, we employ high throughput screening (HTS), cheminformatics, and medicinal chemistry of novel small molecule reagents that aid in validating novel therapeutic approaches and in understanding the biology of signaling in the central nervous systeIn addition, we employ high throughput screening (HTS), cheminformatics, and medicinal chemistry of novel small molecule reagents that aid in validating novel therapeutic approaches and in understanding the biology of signaling in the central nervous systein validating novel therapeutic approaches and in understanding the biology of signaling in the central nervous systein understanding the biology of signaling in the central nervous systein the central nervous system.

Using these approaches in combination with genetics, molecular biology and biochemistry, we are studying the molecular mechanisms underlying synaptic transmission and plasticity in mammalian central nervous system.

ISB's Connection: With a mission to tackle biological complexity, ISB has pioneered systems biology approaches that put our scientists and collaborators in a prime position to take on the challenge of demystifying the brain.

Then for postdoctoral research I moved to Yale University, where I worked in a lab that looked at all kinds of different disease areas using the approaches of a field called chemical biology, which is using small molecules — chemicals — to probe biological systems in the hopes of developing compounds that could be new drugs.

It uses cutting - edge approaches to understand entire systems involved in complex biology, from a cell to the central nervous system.

New data and research approaches have created opportunities for researchers to study in detail many aspects of cancer biology, including how the normal biological programs of cell proliferation and death are altered during cancer and how the immune system responds to tumors.

Specifically, the authors call for systems biology approaches (using large data sets and modeling to understand complex biological systems) to fill critical knowledge gaps in understanding how Mycobacterium tuberculosis (Mtb) infection causes disease.

Functional medicine reflects a systems biology approach to health care: a comprehensive analysis of the manner in which all components of the human biological system interact functionally with the environment over time.

The intensive year - long instruction combined a systems biology approach to health with an in - depth concentration on root cause of disease, coupled with therapeutic dietary treatment, and stress management techniques.

Dr. Brady will discuss autoimmune disease as a complex entity and «perfect storm» of biological and environmental factors and will present a systems - biology approach, utilizing a wider - lens perspective, as a suggested strategy and clinical algorithm for the clinician to consider in working through these complex clinical scenarios.