Sentences with phrase «in the mma patients»
With further studies, the researchers identified increased production of free radicals in tissues from the mice, as well as in the MMA patients.
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Plasma levels of this biomarker rose with kidney deterioration in patients with MMA, and may serve as a valuable indicator of MMA kidney disease progression in the clinic.
Researchers at the National Human Genome Research Institute (NHGRI), part of NIH, validated the same biomarkers in 46 patients with MMA seen at the NIH Clinical Center.
The researchers chose one of the biomarkers, called lipocalin - 2, to test how it correlated with kidney function in 46 MMA patients.
The researchers performed the studies using mice bred to carry gene alterations that disrupt the production of the same mitochondrial enzyme that is defective in patients with MMA.
A team led by researchers at the National Institutes of Health has overcome a major biological hurdle in an effort to find improved treatments for patients with a rare disease called methylmalonic acidemia (MMA).