Sentences with phrase «in the disease progression»

In men who were given abiraterone there was a 70 per cent reduction in disease progression.

But recent studies in both humans and lab mice have suggested that motor neurons in the brain — the upper motor neurons — may be involved in disease progression, although the extent and significance of this involvement has remained unknown.

The more we know about the steps that occur in disease progression, the more opportunities we have to intervene with potential therapies.»

Next steps for the team include identifying microbiota metabolites whose levels are either significantly elevated or depleted during diseases such as IBD or cancer, to find disease - specific markers and explore possible roles for these metabolites in disease progression.

This work identifies novel steps in disease progression that could potentially be targeted by drugs to halt cognitive decline.

They found significant differences in disease progression, immune system response, and neurological effects between the two models.

In fact, different genes may play a role in IA development while others play a role in disease progression, the TEDDY scientists write.

Results from these behavioral assays show that J147 has the ability to rescue the cognitive decline and disinhibition phenotype associated with AD when administered at an extremely late stage in the disease progression when pathology is already far advanced.

Using mouse models of MS, Dr. Akassoglou has shown that higher levels of these proteins are early indicators of MS and key contributors to neuron damage, resulting in disease progression.

Overall, these data expand the prognostic role of histone modification in disease progression in PTCL - NOS.

And even the exact role of pressure in disease progression has come under scrutiny, as sight can be preserved despite high IOP.

Oxygen Consumption measurements have become a key functional readout of cell metabolism and mitochondrial function, providing important insights into the cell function and role of perturbed metabolism in disease progression.

However, reliable biomarkers are required to allow such growth - promoting approaches to be applied early in the disease progression.

Researchers revealed whole genome doubling as a milestone in disease progression and discovered a potential biomarker that is based on DNA methylation that may inform ACC drug therapies.

There is growing awareness of the need to consider sex in disease progression, but limited attention has been paid to sexual dimorphism in mouse models and its impact in metabolic phenotypes.

Further, the ability to detect minute changes in these biomarkers enables the identification of at - risk patients earlier in their disease progression to guide more personalized, preventive care.

Integrated pathway analysis implicated the involvement of extracellular matrix degradation, collagen catabolism and angiogenesis in disease progression.

The damage to the joints from RA occurs early in the disease progression.

«Improvement was evident only in top performing cats, suggesting that SAMe (Novifit) is most effective when used early in disease progression.»

The unique characteristics of heartworms in the feline host help explain the differences in disease progression that cats undergo after infection.

The SOD1B mutation is detected much less frequently (3 %) than the 118G > A mutation (38 %) in BMD but could play a role in disease progression.

There is a highly significant seasonal incidence of diagnosis of canine diabetes with the incidence peaking in winter, which indicates that environmental influences have a role in disease progression just before diagnosis.

The most striking feature of Swedish vallhund PRA / retinopathy is the individual variability in disease progression, even among related dogs and those raised in similar environments.

Not exact matches

Amgen Executive Vice President of Research and Development Sean Harper said the study was designed to explore Kyprolis dosing regimens, noting that the the trial did not meet its goal in improving progression - free survival versus Velcade in patients who had not yet been treated for the disease.

Precision medicine is the «cure» piece, but even that isn't possible if we don't move the intervention curve closer and accurately predict and prevent early enough in the progression of disease.»

Until now, there was no reimbursable way for pre-diabetic patients to receive care, said Mike Payne, head of medical affairs at Omada Health, the nation's largest federally recognized provider of diabetes prevention programs in the U.S. Medicare has always reimbursed providers to screen for diabetes and to treat those who have the disease, but there wasn't a way for providers to be reimbursed to stop that progression all together.

The technology measures the stage of disease, rate of progression of disease, drug efficacy, and drug toxicity in several cancers and Alzheimer's disease.

That delay followed the failure of a trial in November of Lilly's experimental Alzheimer's treatment solanezumab, which the company had hoped would be the first medicine approved to slow progression of the disease.

The biotech specialist said that its updated phase 2 data in a study of its poziotinib candidate treatment for non-small cell lung cancer resulted in a preliminary confirmed objective response rate and potential progression - free survival benefit in patients with the EGFR Exon 20 Mutant form of the disease.

For example, Eli Lilly & Co. (NYSE: LLY) has a phase 3 study of solanezumab under way in mild to moderate Alzheimer's disease patients that may slow disease progression by breaking up amyloid plaque buildups thought to be a major cause of the disease.

Where is the clear line in a progression from (1) using animal insulin to treat diabetes, to (2) using gene remodeling techniques to grow insulin in a host bacterium that will reproduce rapidly and from which a plentiful supply of insulin can be harvested, to (3) genetic surgery to replace the defective gene in a person diagnosed as diabetic, to (4) genetic surgery immediately after fertilization in order to replace the defective gene and alter the germ cells which would otherwise have transmitted the disease to one's offspring?

Some of the marketing material highlighted in Lion's cross claim includes: «A2 will improve human health through the consumption of a2 dairy milk products», «studies suggest that milk containing only the A2 type of protein may benefit you and your family if you're concerned with certain allergies, immune function or digestive wellbeing» and «there is significant evidence to suggest that beta casein A1 may be a primary risk factor for heart disease in adult men and also be involved in the progression of insulin dependent diabetes in children... Beta casein A1... is the most powerful risk factor ever discovered.»

So the company «knocked» the ordinary milks, claiming that «beta casein A1 may be a primary risk factor for heart disease in adult men, and also be involved in the progression of insulin - dependent diabetes in children».

One study, published in the «Journal of Alzheimer's Disease» in October 2013, found that the oil in coconut helps shield nerve cells from the toxic effects of protein plaques, which would otherwise drive Alzheimer's disease progrDisease» in October 2013, found that the oil in coconut helps shield nerve cells from the toxic effects of protein plaques, which would otherwise drive Alzheimer's disease progrdisease progression.

Not only was that assertion completely at odds with the uncertain state of the existing science, but it was contradicted by the study itself, in which Dr. McKee and her colleagues acknowledged that several other factors, besides prior participation in football, may influence CTE risk and disease severity, including factors other than cumulative hits to the head, and admitted that it was even «unclear» what roles concussions and repetitive subconcussive hits play in CTE risk, disease severity, and progression.

It has been noted that an injury to a person's blood vessels in their brain may actually dramatically alter the progression as well as onset of Alzheimer's disease.

I have a rare genetic disease (only 500 in the U.S.) and during pregnancy I had to stop taking the only medication I have to slow down the progression.

The researchers, including first author Matheus Victor, PhD, a postdoctoral research associate, set out to generate neurons that would mimic those of adult patients in order to model the onset and progression of Huntington's disease.

«In theory, we could model progression of the disease by reprogramming skin cells from patients at a range of ages, including before symptoms begin.

This technique lets us capture characteristics of the disease at distinct moments in its progression.

They also believe that by measuring a patient's dark adaptation response time they have developed a tool that can help track the onset or progression of the disease as well as measure the effectiveness of drugs that are in development to treat the disease early on.

SAMHD1 isn't a molecular «good guy» or «bad guy» per se, but there are cases in which blocking its activity might thwart disease progression, said Li Wu, the study's senior author and a professor of veterinary biosciences and microbial infection and immunity in Ohio State's Center for Retrovirus Research.

«This study is important, in part because we now have a new xenograft model that will for the first time allow us to apply new biomarkers to better predict disease progression and test new therapeutics.»

The new study, called FOR - DMD (Finding the Optimum Regimen of Corticosteroids for Duchenne Muscular Dystrophy), will determine whether daily steroid treatment or an alternative regime is more effective in slowing the disease progression and managing side effects.

Still, researchers are intrigued by the possibility that cells may use these clearance mechanisms to propagate misfolded proteins throughout the brain — in which case targeting the mechanisms could conceivably slow disease progression.

«While many people become discouraged about Alzheimer's disease because they feel there's little they can do to protect against it, these results suggest that engaging in moderate physical activity may slow down the progression of the disease.»

Next up: a larger trial in hundreds of patients to see if lowering mutant Htt protein slows progression of the disease, then a trial in healthy people who carry the mutant HTT gene to see if antisense treatments could prevent Huntington's altogether.

Unlocking the precise way in which it influences disease progression is one of the goals of Wu's lab.

Now the researchers set out to identify markers of HD in non-neural tissues that could be used to track the progression of the disease and its response to P110 or other candidate drugs.

In a groundbreaking development, results from a recent clinical trial to treat lung cancer show that a novel immunotherapy combination is surprisingly effective at controlling the disease's progression.