Sentences with phrase «in the gene expression as»

Understanding enhancer functions is of great interest due to their importance in gene expression as well as evolution and disease.

Changes in gene expression as a response to death, and during subsequent post-mortem ischemia, might be expected to reflect stochastic variation resulting from the enzymatic processes underlying mRNA degradation.

In a developing embryo, for example, a researcher could determine whether or not newly synthesized or long - lived transcription factors control gross changes in gene expression as new body sections are formed.

It is not clear which exact biomarker or combination of biomarkers is responsible for changes in the gene expression as there is a lot happening in the intestinal soup.

Not exact matches

The recent Lancet Breastfeeding Series refers to new discoveries being made about breastmilk — such as its role in gene expression — so it can be expected that Nestle will use the strategy of launching «new improved» formulas that are «closer to breastmilk» for decades to come (Nestle is currently investing heavily in epigentics research).

Our conference for 2018 is packed full of fascinating topics such as the antibacterial properties of human milk carbohydrates, breastmilk as a communication and gene expression tool, management of chronic breast pain, the physiology of the milk ejection reflex, collaboration in high conflict settings, and so much more!

Therefore, we questioned whether PTPRF gene expression might be elevated in Mature Group 2 samples, as PTPRF overexpression could be causing excessive downward modulation of the insulin signaling pathway in the women with lower insulin sensitivity.

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

RNAs contained in this non-coding part act as regulatory molecules and have a large impact on gene expression: where in the body and when during development or adulthood genes are expressed.

Messenger RNA (mRNA) serves as an important intermediary during gene expression, by relating the genetic information of DNA to the molecular mechanisms involved in manufacturing proteins.

Recent advances in the understanding of cancer have led to more personalized therapies, such as drugs that target particular proteins and tests that analyze gene expression patterns in tumors to predict a patient's response to therapy.

This image shows the metabolic expression of a gene identified by scientists from EPFL in Lausanne and ETH Zürich as being a key player in the development of type 2 diabetes.

The authors describe dengue as inducing more robust changes in gene expression than either strain of Zika.

Gene expression is the process whereby the genetic information of DNA is used to manufacture functional products, such as proteins, which have numerous different functions in living organisms.

Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.

«It was a little eerie and a little scary to see how something as subtle as a nutritional change in the pregnant mother rat could have such a dramatic impact on the gene expression of the baby,» Jirtle says.

PATTERNS of gene expression in a woman's blood may give a clue as to whether she is likely to get pregnant using IVF.

«By observing neuronal gene expression in these distinct pathways during development, we detected common patterns, as if an underlying genetic language was bringing them together.»

Prasher and Chalfie were awarded a patent for the use of GFP as a marker of gene expression; in total, it earned Prasher just a few hundred thousand dollars in royalties over 15 years.

The study's 31 samples of dog tumors was compared to 40 normal canine tissues samples as a way of estimating the variance in gene expression.

The researchers have compared various processes involved in gene expression, such as gene transcription and chromatin modification, and have repeated this in different tissues and cell types from both humans and mice.

By tracking activity in almost all the genes of a free - living archaeon — which, like a bacterium, is a prokaryote — Bonneau was recently able to piece together how the genes affected one another's expression, enabling him to map the organism's «control circuit» as if it were a machine.

According to Izpisúa Belmonte, who is also a professor at the gene expression laboratories of the Salk Institute for Biological Studies in San Diego, California, CMRB aims to become «a research centre of excellence in south Europe in the line of world - recognized institutions such as the Salk or the Whitehead institutes, where both pre - and postdoctoral researchers receive multidisciplinary training of the highest quality» in stem cell biology and cell regeneration.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

Rho, found in many bacteria, acts as a protein regulator of bacterial gene expression, determining which genes get turned on or off.

They identified 60 genes that exhibited convergent evolution in CAM species, including convergent daytime and nighttime gene expression changes in 54 genes, as well as protein sequence convergence in six genes.

Together, the two proteins act as a nano - machine that can be used to trigger gene expression in cells.

Sure enough, salmon with a certain pattern of gene expression in their gill tissue were 13.5 times more likely to die than those that didn't carry the «you've not got long to live» signature, as co-author and University of British Columbia (U.B.C.) fish physiologist Tony Farrell puts it.

Global gene expression studies found that the LPA - treated mice shared many similar molecular markers as those found in humans with schizophrenia.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

Enzymes that chemically modify DNA, known as DNA methyltranferases, play critical roles in regulating gene expression during development, but their role in cancer formation is less clear.

It isn't clear exactly why the differences fade, Hochedlinger says, but it may be that the expression of embryonic genes is strengthened as the cells grow in culture, gradually overwriting the cells» old gene - expression patterns.

The new work, published today in Cell Reports, finds that the protein ADR - 1 binds to messenger ribonucleic acid, or mRNA, and then enhances RNA editing, a process that allows a gene to be present as multiple mRNAs that can then each affect gene expression differently.

«The 20 - year difference in expression of the gene abnormality shows the devastating consequences of recent environmental factors, such as eating high - glycaemic foods and a lack of exercise,» Froguel says.

This so - called microRNA disrupts the expression of two key cellular genes called TGF - β and SMAD3, in a process known as RNA interference (RNAi).

The researchers found that the blond hair commonly seen in Northern Europeans is caused by a single change in the DNA that regulates the expression of a gene that encodes a protein called KITLG, also known as stem cell factor.

The researchers investigated 16 groups of female and male mice offspring exposed to maternal diet - induced obesity and male hormone excess and studied how these environmental factors affected the mice's behaviour as well as gene expression in the brain.

As sensitive as alternative splicing reacts to (slightly) elevated temperature, a temperature - induced change in gene expression by fever appears to be a logical consequencAs sensitive as alternative splicing reacts to (slightly) elevated temperature, a temperature - induced change in gene expression by fever appears to be a logical consequencas alternative splicing reacts to (slightly) elevated temperature, a temperature - induced change in gene expression by fever appears to be a logical consequence.

The gene expression similarities between this common condition and the current findings in late - stage RP suggest that the canine RP models could serve as stand - ins to evaluate the effectiveness of pharmaceutical interventions that target innate immunity pathways in AMD

This magic spot was later identified as ppGpp and shown to influence the expression of over 500 genes in response to stress.

Histones and other proteins, when modified by this process known as acetylation, play critical roles in regulation of gene expression, typically resulting in increased gene expression.

When the researchers started taking weeds out of the corn at early points, such as when the corn had as few as two and four leaves, they still saw differences in gene expression when compared to corn without weeds.

In aging, this gene expression presumably occurs to compensate for the accumulation of protein damages; during diapause, the same genes may be activated to prepare the whole embryo to catch up with the interrupted development and be ready to hatch as the rainy season starts.

Epiviz implements multiple visualization methods for location - based data (such as genomic regions of interest) and feature - based data (such as gene expression), using interactive data visualization techniques not available in web - based genome browsers.

Using a fluorescent protein to detect Rgs16 expression, the investigators found that this gene is induced by pancreatic tumor formation starting from its earliest manifestation as ductal neoplasm all the way to advanced solid tumor in a spatially and temporally coincidental manner.

What we were surprised to find out was that the real differences we could detect in terms of when we did the swap experiments to say which yeast could outperform the other — what we learned was that the GAL1 gene, that the part [of] that, the DNA sequence is outside of the GAL1 gene, it acts as a switch to turn up or turn down GAL1 expression, that had evolved considerably from the ancestral situation; and same for the GAL3.And then what had happened was that each function had been optimized, that GAL3 had sort have been tuned to be sort of a loosely regulated kind of available anytime sensor of galactose and GAL1 had evolved to be an incredibly tightly regulated, in fact, it's the most tightly regulated gene you know of in yeast.

During development, as an embryo forms differentiated tissues, liver cells, brain cells, muscle cells, the cells in those tissues begin to allow for the selective expression of genes contained in those same 3 billion nucleotides.

«Telomerase is a unique protein - RNA complex where the protein subunit uses its RNA component as a template to add identical fragments of DNA to the end of chromosomes,» said Emmanuel Skordalakes, Ph.D., associate professor in the Gene Expression and Regulation program of Wistar's NCI - designated Cancer Center.

As the worms aged, the team observed dramatic changes in gene expression.

The loss of the mark leads to inappropriate gene expression as shown by the re-expression of genes usually only seen late in embryo development.»