Sentences with phrase «in these disease conditions»

But in disease conditions like muscular dystrophies, satellite cells can't keep up with repeated cycles of injury and are ultimately exhausted or functionally impaired,» Hindi said.

«Resveratrol may have detrimental effects in some disease conditions and should be discouraged for supplemental use by MS patients pending further research,» says lead investigator Ikuo Tsunoda, MD, PhD, Assistant Professor in the Department of Microbiology and Immunology, Center for Molecular & Tumor Virology of the Louisiana State University Health Sciences Center, Shreveport, LA.

In normal conditions, microglial cells do not make APOE; however, in disease conditions, they sense the brain damage and respond by churning out APOE.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Omada's digital therapeutics platform attempts to address disparate health care needs that can be particularly cumbersome for people at risk for chronic diseases like diabetes through a combination of data analytics, user engagement, and the broad goal of preventing these kinds of conditions from developing in the first place.

Political instability and dangerous conditions in Syria have made it difficult to wage a large - scale public health campaign against infectious diseases like polio.

Eventually, the technology could help providers identify more individuals who are at risk of developing cardiovascular conditions — cardiovascular disease not only affects over 100 million people in the US, it is also the costliest disease in the nation, with associated costs reaching $ 555 billion in 2016, according to American Heart Association.

The psoriasis field is among the most lucrative (if not the most lucrative) in biopharma, thanks to a combination of a massive patient pool and the ways in which these treatments can extend to somewhat related immune and inflammatory conditions, like arthritis and Crohn's disease.

But, at least in the venture capital world, funding for companies focused on tackling heart disease, respiratory disease, and other mass population conditions — i.e., those that afflict millions upon millions of people — has dropped sharply in the last decade.

It's not every day that a knock in the head leads to an entirely new approach to treating disease, but that's what sparked SuperBetter, Jane McGonigal's free online game, which introduced a radical new approach to the prevention and treatment of depression, anxiety and other neurological conditions.

A giant new study, reported in the New York Times, found that people who drank between three and five cups of coffee a day had a 15 percent lower risk of dying young from heart disease and several other medical conditions.

While Kallyope hasn't given too many specifics about its drug programs, the company's initial focus will be in metabolic conditions, like obesity, as well as neurologic conditions like Parkinson's disease.

The company is selling a thing (the kit) by saying it can provide «health reports on 254 diseases and conditions,» including categories such as «carrier status,» «health risks,» and «drug response,» and specifically as a «first step in prevention» that enables users to «take steps toward mitigating serious diseases» such as diabetes, coronary heart disease, and breast cancer...» Most of the uses «listed on your website, a list that has grown over time,» the FDA writes, «are medical device uses [for the] Personal Genome Service.»

«We don't have a specific list of conditions that would be disqualifying, but certainly uncontrolled medical problems (whether it's hypertension or heart disease or lung disease, or many other conditions), would most likely cause concern and result in disqualification,» Dr. Tarah Castleberry, an assistant professor of aerospace medicine at the University of Texas Medical Branch in Galveston, told Reuters Health by email.

For the one in four Canadians who suffer from respiratory disease (at least 40 % of whom experience allergic responses that can worsen their conditions), controlling scent in the workplace can greatly improve their lives, not to mention productivity.

The memory - eating disease, expected to afflict 15 million Americans by 2060 (and tens of millions more around the world as life expectancy increases), has no cure; a new drug for the condition hasn't been approved in well over a decade; initially promising experimental treatments seem to be failing with clockwork regularity; and there's not even a definitive consensus on what, exactly, biopharma companies should focus on while developing Alzheimer's medicines.

As the most common cause of dementia, it's the sixth leading cause of death in the US, behind conditions like heart disease and cancer.

Shares of biotech Spark Therapeutics rose 4.5 % in early Monday trading after the Food and Drug Administration (FDA) agreed to review its gene therapy for vision loss patients who have vision loss due to a rare genetic condition called biallelic RPE65 - mediated inherited retinal disease (IRD).

In recent years, Levine and others have used clinical studies to prove that even in healthy people, a chair - based lifestyle sets up the physiological conditions for the onset of Type 2 diabetes, cardiovascular disease, obesity — and ultimately, shorter lifespanIn recent years, Levine and others have used clinical studies to prove that even in healthy people, a chair - based lifestyle sets up the physiological conditions for the onset of Type 2 diabetes, cardiovascular disease, obesity — and ultimately, shorter lifespanin healthy people, a chair - based lifestyle sets up the physiological conditions for the onset of Type 2 diabetes, cardiovascular disease, obesity — and ultimately, shorter lifespans.

He didn't do this just to make money, but he did it in an effort to save his two children from a rare condition called Pompe disease.

«Lying in a makeshift hospital bed in conditions that would make most of us queesy, and thinking it's the bite of a mosquito that brings me to my knees, I thought that I could do something to help prevent this disease and other diseases,» Tifft said.

Dirty air, water, and working conditions are associated with some of the most prominent causes of death in the world, including heart disease, cancer, and lung disease.

(For example, Optiva ads that ran in national consumer magazines claimed that using the competing Braun product wouldn't prevent the growth of bacteria that might contribute to heart disease, stroke, low birth weight, and other life - threatening conditions.)

In addition to people who are paralyzed, the website for the Eyecan says that the creators of the device hoped to improve the quality of life of people with conditions like Lou Gehrig's disease (ALS) and Locked - In Syndrom (LIS).

Day notes that nearly three - quarters of hospital admissions in the U.S. are for conditions linked to eating habits: diabetes, heart disease, hypertension, obesity.

The plan, called 9000 Points of Care, laid out a framework that would see pharmacists treat more minor ailments, like cold sores, hay fever and back pain, administer more vaccines, and play a larger role in managing chronic conditions, like heart disease and diabetes.

Clean the World has a mission to put soap in the hands of people who need it most to improve hygiene and sanitation conditions, to reduce the impact of disease and to promote better hygiene and living conditions worldwide.

«What we're seeing right now» in B.C., and what we saw in Alberta last year, we are conditioned to think of as extreme events,» Sarah Henderson a senior scientist at the B.C. Centre for Disease Control, told Vancouver's Metro News.

Rare diseases are conditions affecting less than 200,000 people in the US and less than five (5) in 10,000 according to the definition adopted by the European Medicines Agency.

And the author comes to some sobering conclusions in the first chapter: only massive upheaval through wars, revolution, disasters, famine and disease has been successful historically in leveling economic conditions.

Jain elaborated on those successes in an article in the Journal of the American Medical Association last year, noting the efficiencies lead to better outcomes for patients, who can more reliably receive routine medical care and stay out of emergency rooms; doctors, who can more easily manage patients» chronic conditions; and cost - savings for the broader medical system, as managing chronic disease is substantially cheaper than repeated ER visits.

As for what Deming and company are looking for, she suggests the program is particularly interested in working with startups that are committed to addressing late - onset medical conditions relating to Alzheimer's, heart disease, diabetes and more.

If these parameters were needed to define a god, should he exist, would you not say that with all of the suffering and death and disease in the world, that the existence of god through the condition of our species would be more readily disproved than anything?

With Satan in command of mankind, moral conditions have went from «bad to worse», culminating in our time period that is full of hunger, disease and rottenness in people.

In life, in spirit and in body, these persons exist in a condition of disease, destruction and misery that is beyond imaginatioIn life, in spirit and in body, these persons exist in a condition of disease, destruction and misery that is beyond imaginatioin spirit and in body, these persons exist in a condition of disease, destruction and misery that is beyond imaginatioin body, these persons exist in a condition of disease, destruction and misery that is beyond imaginatioin a condition of disease, destruction and misery that is beyond imagination.

Pregnancy, however, falls comfortably into none of the usual definitions of disease: it is not a state inimical to the way one is supposed to feel; it is not a condition in which body components and systems are acting inharmoniously (to the contrary, infertility would more likely fall within that definition); it is not a state of abnormality — for the pregnant woman functions satisfactorily within society, and the social and physical environment tolerates the pregnant woman perfectly.

-- appears to have the potential to lower the incidence of common conditions such as cancer, coronary heart disease, allergies and hyperactivity in children.

In regarding mental illness as symptomatic of the diseased general condition of humankind, faith relativizes the simplistically absolute distinction between the sick and the well, and calls attention to a deeper, less obvious level of selfhood.

Wednesday in St. Peter's Square, Pope Francis met, embraced and kissed a man suffering from a rare disease called neurofibromatosis, a painful and disfiguring skin condition.

My eschatological death, therefore, terminates my participation in the human condition of sin that dominates the old moral order as well as the alienation that that disease engenders.

Man can reshape the conditions of his life, change the face of nature, eliminate killing diseases, reconstruct the human body, control the growth of population in ways beyond anything remotely conceivable before the twentieth century.

Seeing a spot on a man's arm, a priest judges it «skin disease» or «scab,» and his application of Torah determines the man's condition in relation to the tabernacle.

Under primitive conditions man was so at the mercy of wind and storm, heat and cold, drought and rain, mysterious diseases and unpredictable disasters, that the first, natural explanation of his good or evil fortune was sought in the will of superhuman forces.

In certain diseased conditions consciousness is a mere spark, without memory of the past or thought of the future, and with the present narrowed down to some one simple emotion or sensation of the body.

Hasker's third proposition is that for the problem of divine non-intervention to be a real problem, «we must be able to identify specific kinds of cases in which God morally ought to intervene but does not» Many critics of (traditional) theism probably already have a more or less vague list of such cases, which might include genocidal events, such as the Nazi holocaust and the Rwandan massacre; wars; large - scale natural disasters; conditions of chronic poverty, in which millions of children die from starvation or are permanently stunted because of inadequate protein; the sexual molestation of children, which often leaves them psychologically scarred for the rest of their lives; death preceded by long, painful illnesses, such as cancer or AIDS, or by mind - destroying conditions, such as Alzheimer's disease; and the kinds of events described by Dostoyevski, such as the soldier using his pistol to get a mother's baby to giggle with delight and then blowing its brains out.

A third - time Olympian who overcame Perthes disease, a condition which forced him in leg braces as a child for a year, Brady Ellison is looking for his first gold medal this month.

Celiac disease is an autoimmune condition in which the gut becomes inflamed in response to gluten.

Information found in these slideshows is helpful to those who suffer with health conditions related to gluten - sensitivity, allergies and serious chronic conditions such as celiac disease.

In this way, it may decrease the risk of inflammation - related conditions such as cardiovascular disease, diabetes, cancer, and obesity.

Well, the truth is, the cow industry is inhumane, (the overcrowded transportation conditions alone lead to to great suffering, severe cruelty and broken limbs), unhealthy (cows are pumped full of hormones, adrenalin from the fear from when they know they will be killed and anti-biotics — because the unhealthy conditions they live in promote infection and disease) and inefficient (cows must be fed 3 times the edible human grain than their bodies produce in meat).