Some (8 per cent) of the treated women even experienced a significant increase
in trabecular bone density.
Example of longitudinal changes
in trabecular bone volume fraction (BV / TV) and trabecular number (Tb.N) for Sham and OVX groups.
Dr. Vranka's project studied Versican, a large proteoglycan that is known to interact with many other proteins also present
in the trabecular meshwork, which is thought to be the primary contributor to outflow resistance.
Dr. Keller was awarded the 2010 Shaffer Prize for Innovative Glaucoma Research for her research investigating the role of Glycosaminoglycans (GAGs) in fluid outflow resistance
in the trabecular meshwork of the eye.
Project: Pathological Alterations
in the Trabecular Meshwork Following Vitrectomy and Lens Extraction: A Model of Oxidative Stress
Carla J. Siegfried, MD Washington University School of Medicine, St. Louis, MO Funded by The Alcon Foundation Project: Pathological Alterations
in the Trabecular Meshwork Following Vitrectomy and Lens Extraction: A Model of Oxidative Stress
Figure 8A shows the concave surface of a vascular canal
in trabecular bone.
Not exact matches
Its impact appears to reduce the ability of the cells
in the eye's
trabecular meshwork to continually move the clear aqueous humor out of the front of the eye and dump it into the body's general circulation, said Liu, corresponding author of the study
in the journal Investigative Ophthalmology & Visual Science.
The small increase
in the high - dose group did not translate into beneficial effects because authors found no difference between the three study groups for changes
in spine, average total - hip, average femoral neck or total - body bone mineral density,
trabecular bone score, muscle mass or sit - to - stand tests.
When the team scanned hand bones from four members of A. africanus that lived
in South Africa between 2 million and 3 million years ago, they found that the pattern of the
trabecular bone was asymmetrical, as
in modern humans and Neandertals that use tools frequently (as they also show
in their study).
One innovative aspect of the study was the measurement of bone texture of the lumbar spine using
trabecular bone score (TBS)- the first use of this technique
in adolescent athletes.
Discussion: Overall, quantified
trabecular parameters represent overall differences
in bone strength between the two species, however, DA may be directly related to joint loading.
Trabecular architecture
in the thumb of Pan and Homo: implications for investigating hand use, loading, and hand preference
in the fossil record
Traditional analyses have quantified cortical or
trabecular structure
in only selected regions of a bone, such as single cross-sections of cortical bone or volumes of interest of
trabecular structure
in epiphyses.
Materials and methods: We apply a whole - bone / epiphysis approach to analyze
trabecular and cortical bone
in the distal tibia and talus of Pan troglodytes and Homo sapiens.
Objectives: Internal bone structure, both cortical and
trabecular bone, remodels
in response to loading and may provide important information regarding behavior.
Recently published findings suggest that WBV increases
trabecular and cortical bone mass
in db / db mice (44), but these effects differ from the modest skeletal responses observed after exercise and WBV
in the current study.
The research, titled «Human - like hand use
in Australopithecus africanus, shows that Australopithecus africanus,» a 3 - 2 million - year - old species from South Africa traditionally considered not to have engaged
in habitual tool manufacture, has a human - like
trabecular bone pattern
in the bones of the thumb and palm (the metacarpals) consistent with forceful opposition of the thumb and fingers typically adopted during tool use.
Here we show that Australopithecus africanus (~ 3 to 2 million years ago) and several Pleistocene hominins, traditionally considered not to have engaged
in habitual tool manufacture, have a human - like
trabecular bone pattern
in the metacarpals consistent with forceful opposition of the thumb and fingers typically adopted during tool use.
The
trabecular structure of the talus is more divergent than the tibia, having thicker, less uniformly aligned trabeculae
in Pan compared to Homo.
Differences
in dorsiflexion at the talocrural joint and
in degree of mobility at the talonavicular joint are reflected
in the distribution of cortical and
trabecular bone.
Trabecular bone remodels quickly during life and can reflect the actual behaviour of individuals
in their lifetime.
Cortical and
trabecular bone distributions correlate with habitual joint positions adopted by each species, and thus have potential for interpreting joint position
in fossil hominoids.
Other data obtained
in this report (BrdU nitroblue tetrazolium staining by alkaline phosphatase and fluorescence due to fluorescein) would further suggest that putative stem cells are located
in the posterior limbus between the peripheral endothelium and the
trabecular meshwork.
The area of the
trabecular meshwork and its surrounding posterior limbus
in the human, however, showed considerable fluorescence indicative of cell division (Figure 6B).
Conclusions: It is suggested stem - like cells may be sequestered
in a niche at the junctional region where the corneal endothelial cells and the
trabecular meshwork come together.
No activity was observed
in the central endothelial tissues or the limbus between the
trabecular meshwork and Schwalbe's line.
In this report, no telomerase activity in the limbal region from Schwalbe's line to the trabecular meshwork was detecte
In this report, no telomerase activity
in the limbal region from Schwalbe's line to the trabecular meshwork was detecte
in the limbal region from Schwalbe's line to the
trabecular meshwork was detected.
The effect of glucocorticoid treatment is most prominent on
trabecular bone and is therefore likely to be larger on vertebral bone than on hip bone.3 Glucocorticoids are associated with an increased rate of fracture, and higher doses and longer use of glucocorticoids are associated with higher risks of fracture.4 Compared with patients not taking glucocorticoids, the risk of hip and vertebral fracture among patients taking glucocorticoids is increased by 60 % and 160 %, respectively.4 Among 80 - year - old patients, the hip fracture risk is increased by a magnitude of 2.1 and is independent of BMD.5 Most studies indicate that fracture risk is increased following at least 3 months of treatment with daily doses of 5 mg of prednisolone or more
in older men and women.4
There was also increased fluorescence
in the area of the
trabecular meshwork and posterior limbus of greater magnitude than
in the unwounded condition (Figure 7B).
However, we have found a fluorescent marker for nestin, a neural crest stem cell marker,
in the posterior limbal region of the human anterior segment
in the vicinity of both the
trabecular meshwork and Schwalbe's line (unpublished).
When BrdU fluorescence assays were made on corneal transverse sections with fluorescein, fluorescence occurred
in an area just at and adjacent to the
trabecular meshwork, but was not seen at the corneal endothelium.
By way of contrast, considerable fluorescence was observed
in the area of the
trabecular meshwork and the posterior limbus (Figure 6B).
The authors say that it's possible that the new
trabecular meshwork cells generated from the stem cell treatment could eventually succumb to the same mechanisms that caused the fluid buildup
in the first place, but further research is needed
in that area.
ICS offers new capabilities for analysing bone dynamics including both
in vivo and ex vivo analysis of
trabecular and cortical bone structures by MicroCT.
Project: Nanoengineered
In Vitro
Trabecular Meshwork ™ Model for Systematic Investigation of Aqueous Humor Outflow Resistance
In most instances, OH results from impaired drainage of aqueous humor through the
trabecular meshwork ™.
TGF - Î ² 2 is known to elevate IOP by promoting increases
in aqueous humor outflow resistance through the
trabecular meshwork.
In the lamina cribrosa, like the trabecular meshwork we hypothesize that exosomes participate in the turnover of extracellular matrix and homeostatic signaling with cell neighbors, particularly in response to elevations in intraocular pressure / pulsation
In the lamina cribrosa, like the
trabecular meshwork we hypothesize that exosomes participate
in the turnover of extracellular matrix and homeostatic signaling with cell neighbors, particularly in response to elevations in intraocular pressure / pulsation
in the turnover of extracellular matrix and homeostatic signaling with cell neighbors, particularly
in response to elevations in intraocular pressure / pulsation
in response to elevations
in intraocular pressure / pulsation
in intraocular pressure / pulsations.
Our lab has recently shown that endogenous TGF - Î ² 2 expression can be markedly and significantly attenuated
in human
trabecular meshwork cells and porcine anterior segments using the compound XJB -5-131, a novel antioxidant that targets a cell's mitochondria.
RPB investigators have found that the normally spongy cells of the
trabecular meshwork (TM) might be hardened by calcification
in the eyes of people with glaucoma.
Accelerated rates of bone growth and bone remodeling act
in concert to produce a pattern of epiphyseal spongiosa that is composed of fine
trabecular systems that are spaced relatively far apart and that are ultimately less strong per unit area than
in small breeds of dogs.