Apart from patient testimonials and a few preliminary studies
in tumor cell lines and in mice, critics say, there is no evidence of the safety or efficacy of the compound, popularly known as the «cancer pill» or «fosfo.»
Not exact matches
Capsaicin additionally produced a significant deceleration of the development of prostate
tumors created simply by those human
cell lines grown
in mouse models.
Introducing human prostate cancer
cell lines into mice, Wu and his colleagues saw a particular enzyme called MAOA activate a cascade of signals that made it easier for
tumor cells to invade and grow
in bone.
CCG is also developing
cell lines that are cultured to represent
tumor behavior
in vivo, and computational methods that will help researchers understand
tumor behavior and apply the resulting data to diagnoses, treatments, and cures.
«This model was trained on genetic data from human
tumors in The Cancer Genome Atlas and was able to predict response to certain inhibitors that affect cancers with overactive Ras signaling
in an encyclopedia of cancer
cell lines,» Greene said.
«Considering that PDPN is associated with poor prognosis
in GBM, CAR T -
cell therapy that targets this protein is promising for treatment of patients with relapsed or resistant
tumors following first -
line chemotherapy,» says Toshihiko Wakabayashi, a coauthor and the chair of Department of Neurosurgery Nagoya University School of Medicine.
The researchers also tested a Runx2 knock - down variant of a human multiple myeloma
cell line and found that it produced significantly less
tumor growth
in immunodeficient mice than the original human multiple myeloma
cells.
Until recently, Ain was renowned for a highly prized repository of 18 immortal cancer
cell lines, which he developed by harvesting tissue from his patients»
tumors after removal, carefully culturing them to everlasting life
in vials.
They found out that TiY is capable of distinguishing TICs from non-TICs
in various human lung cancer
cell lines and patient - derived lung
tumors.
CNIO's Bioinformatics Unit has been key
in comparing 900
cell lines derived from up to 35
tumor types
in order to identify unique aspects of melanoma.
Overexpression of ZMYND11
in an osteosarcoma
cell line and a triple - negative breast cancer
cell line inhibited
tumor growth.
ICELL8 can isolate up to 1,800 single
cells, ranging from 5 μm — 100 μm
in size on a single chip, including
cells from solid
tumors, brain
cells, pulmonary airway
cells, and multiple
cell lines.
In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to sprea
In earlier studies involving animal models and human cancer
cell lines, researchers found that breast cancer spreads when three specific
cells are
in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to sprea
in direct contact: an endothelial
cell (a type of
cell that
lines the blood vessels), a perivascular macrophage (a type of immune
cell found near blood vessels), and a
tumor cell that produces high levels of Mena, a protein that enhances a cancer
cell's ability to spread.
This technique is able to distinguish cancer
cell lines with differing metabolic activities and reveals heterogeneous uptake patterns
in neurons, mouse brain tissues and
tumor tissues with clear
cell - to -
cell variations.
EZH2 inhibition delayed
tumor onset
in KDM6A - null
cells and caused regression of KDM6A - null bladder
tumors in both patient - derived and
cell line xenograft models.
But
in at least one case, a small
tumor merged with the
cells lining the faux blood vessel.
The research team analyzed BRAF inhibitor resistance
in melanoma
cell lines, mice bearing human melanoma
tumors, and
in human
tumor biopsy samples.
In the fetal liver hybridomas, which were constructed from fetal liver cells and a tumor cell, no light chain gene rearrangement was observed, whereas in the 70Z / 3 cell line a kappa light chain rearrangement probably occurre
In the fetal liver hybridomas, which were constructed from fetal liver
cells and a
tumor cell, no light chain gene rearrangement was observed, whereas
in the 70Z / 3 cell line a kappa light chain rearrangement probably occurre
in the 70Z / 3
cell line a kappa light chain rearrangement probably occurred.
In experiments with cancer cell lines, the PIM1 inhibitors killed cells in a MYC - dependent manner, and in two different mouse models — one in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regressio
In experiments with cancer
cell lines, the PIM1 inhibitors killed
cells in a MYC - dependent manner, and in two different mouse models — one in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regressio
in a MYC - dependent manner, and
in two different mouse models — one in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regressio
in two different mouse models — one
in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regressio
in which mice were implanted with patient
tumors and the other
in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regressio
in which a genetic alteration of MYC predisposes the mice to
tumor development — the administration of PIM1 inhibitors resulted
in significant tumor regressio
in significant
tumor regression.
In a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kil
In a four - year study conducted on the mouse model
in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kil
in advanced breast cancer metastasis
in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kil
in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed
tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kil
in the eye, but also extended the survival of experimental mice bearing 4T1
tumors, a
cell line that is extremely difficult to kill.
In studies of laboratory - grown human
tumor cell lines, the drug disrupted
tumor cell division and prevented growth of advanced cancer
cells.
«While we expected to find some mutations
in stem
cell lines, we were surprised to find that about five percent of the stem
cell lines we analyzed had acquired mutations
in a
tumor - suppressing gene called p53,» said Merkle.
Genomic data from the HeLa
cell line are also being released with the final version of the paper as a result of discussions between leaders of the National Institutes of Health (NIH) and relatives of Henrietta Lacks, from whose cervical
tumor the original HeLa
cell line was derived prior to her death
in 1951.
When the
cell line was established
in the 1960s, material from the original
tumor was saved as thin sections on microscope slides.
Cell lines are therefore indispensable in medical research and a large number of cell lines exist that originate from many different tumor ty
Cell lines are therefore indispensable
in medical research and a large number of
cell lines exist that originate from many different tumor ty
cell lines exist that originate from many different
tumor types.
Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin — the active ingredient
in chili peppers — produces chronic activation of a receptor on
cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal
tumors.
In contrast to other cultured
cells, such
tumor cells can divide indefinitely and a
cell line can therefore be cultured for many years.
Timothy Wang at Columbia recently published work
in Cancer
Cell (DOI: 10.1016 / j.ccell.2016.11.005) that showed that recruitment of nerves into the
tumor microenvironment is necessary and sufficient for stomach cancer progression, and that blocking a neurotransmitter
in the nerves that
line the stomach could represent a novel therapy.
Lutz and Falkowski cite one study where unique chemical compounds isolated from an actinomycete strain inhabiting deep - sea sediments about 3.3 kilometers down
in the South China Sea have shown potent activities against three cancerous
tumor cell lines and also showed antibacterial activities.
A University of Colorado Cancer Center study published
in the journal Oncogene used next - generation sequencing technologies to perform the most detailed DNA - based analysis to date of 25 commonly used bladder cancer
cell lines, allowing researchers to match patient
tumors with their closest genetic
cell line match, and demonstrated genetic alterations that may make
cells more or less sensitive to common therapies.
In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channe
In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device
in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channe
in which
cells from a human intestinal
cell line originally isolated from a
tumor were cultured
in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channe
in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial
cells in the adjacent channe
in the adjacent channel.
In cell lines, the researchers first tested ruxolitinib, a general JAK inhibitor, but it did not block tumor formation in the JAK2 - amplified cell
In cell lines, the researchers first tested ruxolitinib, a general JAK inhibitor, but it did not block
tumor formation
in the JAK2 - amplified cell
in the JAK2 - amplified
cells.
Researchers believe it is the largest epigenetic study yet for any single cancer type and, importantly, the first to use a large cohort of primary patient
tumor tissues instead of
cell lines grown
in the laboratory.
The three Group 3 medulloblastoma
cell lines used
in this study reinforced the observation, highlighting significant differences
in epigenetic regulators at work
in medulloblastoma
cell lines versus
tumor samples.
As famously chronicled
in science writer Rebecca Skloot's best - selling book, the
cell line was established, without Lacks's consent, from a cervical
tumor that she was diagnosed with
in 1951.
When a chemical that inhibits entosis was applied to a
line of breast cancer
cells, colony formation — an indicator of
tumor growth
in vitro — increased 10-fold.
Such targets have recently been discovered
in cell lines derived from aggressive childhood
tumors using phenotypic profiling and RNAi screening.
«By using an animal model to expand
tumor cells recently removed from patients, we hoped to re-create more closely what actually happens
in patients with pancreatic cancer rather than by using existing artificial
cell lines,» said Wei Zhang, Ph.D., an endowed Hanes and Willis Family Professor
in cancer at Wake Forest School of Medicine, a part of Wake Forest Baptist, and principal investigator of the study.
However, efforts to examine the
in vitro behavior of
tumor cells with endothelial
cells from different anatomical regions have been prohibited because,
in large part, of the limited number of organ - derived endothelial
cell lines available for study.
The resulting endothelial
cell lines described
in this study retain their phenotype after repeated passage, require minimal nutritional support and, importantly, may be useful for identifying factors that regulate endothelial
cell proliferation and
tumor cell adhesion
in different anatomical regions.
In this study, NIH scientists used mouse models to show that anthrax toxin proteins work by specifically targeting the
cells that
line the inner walls of the blood vessels feeding the
tumor.
Tumors form
in the pleura, a thin membrane of
cells that
line the lungs and chest wall.
Lloyd A. Greene and Arthur S. Tischler of the Harvard Medical School demonstrated
in 1977 that
cells of the
line designated PC12 (which are derived from a rat
tumor) respond to NGF by acquiring properties characteristic of sympathetic neurons.
The immortalized endothelial
cell lines established from H - 2Kb - tsA58 mice provide, for the first time, a
cell culture system to examine factors regulating angiogenesis and
tumor cell arrest
in different organ systems.
AHERF Neurosciences Grant (G9410 -020-Y01)- Co-PI; «Differential expression and sorting of the neuron - specific class III b - tubulin isotype
in human neuronal and neuroendocrine
tumor cell lines maintained
in an organ culture system».
Interestingly, two recent reports that have catalogued recurrent focal deletions
in large cohorts of human
tumors and cancer
cell lines.
Their theory was first confirmed with ovarian cancer
cell lines and then the Peter / Lengyel team tested HGMA2 protein levels
in tumor samples from 100 patients with ovarian cancer.
The Joslin team found that intestinal
tumors grow just as quickly
in a mouse cancer model whose «epithelial»
cells lining the inside of the intestine have been genetically modified so that insulin can't activate the
cells.
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In cytotoxicity assays employing PPAM, we found no significant differences of IC50 values between SCLC
tumor cells, SCLC CTC
lines which express the Wnt pathway and normal
cells such as HEK293 (data not shown).