Sentences with phrase «in tumor cell proliferation»

«These findings underscore the significance of Gcn5 - regulated gene expression coupled with the metabolic enzyme alpha - KGDH in tumor cell proliferation and formation.»

Not exact matches

Chitayat wonders whether proliferation could proceed in unexpected ways, for example leading to tumors — a worry that cuts across many stem cell therapies.

«One of the major and immediate downstream effects of myc activation is a dramatic increase in the capacity of affected cells to make protein,» Ruggero said «This, in turn, leads to increased cell survival and proliferation, and to unstable genomes that foster additional mutations that turn these abnormal cells into tumor cells.»

«In our study, we demonstrated that alpha - KGDH, when coupled with Gcn5, induces histone succinylation and promotes tumor cell proliferation and tumor development.»

«We demonstrated that alpha - KGDH interacts with Gcn5 in the cell nucleus and found that tumor cell proliferation and tumor growth were inhibited when alpha - KGDH was blocked from entering the cell nucleus or by disruption of Gcn5's binding to succinyl - coenzyme A,» said Lu.

In the new studies, three independent groups used genetic cell - marking techniques to trace the proliferation of certain cells within growing tumors.

«This is not its only effect, Thomas Matthes adds, H225 also significantly limited cell proliferation, even when tumor cells had already settled in the lymphatic system.

New research shows that microRNA - 486 is a potent tumor - suppressor molecule in lung cancer, and that the it helps regulate the proliferation and migration of lung - cancer cells, and the induction of programmed cell death, or apoptosis, in those cells.

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

Next - generation NSG models that support human myeloid cell proliferation, such as the NSG - SGM3 mouse, can now provide in vivo conditions that better mimic the natural tumor environment.

The researchers also note that more investigation is needed to fully understand all the mechanisms by which HOXC10 mediates cell proliferation and death, and the roles it may play in different types of tumors.

Using tumor cells from DLBCL patients, the scientists discovered that the inactivation of BTK in resistant tumors triggers the over-activation of alternative signals that promote tumor cell survival and proliferation.

In Wilms tumors, one set of mutations promotes abnormal and continued proliferation of the undifferentiated cells.

«Foxo1 is a tumor suppressor gene, but it promotes B cell proliferation in the germinal center,» he said.

In the laboratory they showed how morphine can increase proliferation, migration and invasion of tumor cells.

However, an overactive stimulation of mTOR in response to nutrients and growth factors — metabolic processes that are crucial in tumor biology — leads to an increase in cell growth and proliferation.

In a recent study, senior author and Yale pathology professor Wang Min demonstrated that the tumors release substances called cytokines to attract macrophages, which then secrete growth factors that promote tumor cell growth and proliferation.

Loss of this function causes tumor formation through uncontrolled stimulation of AKT, an enzyme that stimulates cell proliferation and survival and is often hyperactive in human tumors.

The absence of tumors in virgin Nrk mutant mice strongly suggests that the tumorigenesis is closely related to the proliferation of mammary epithelial cells during pregnancy.

The resulting endothelial cell lines described in this study retain their phenotype after repeated passage, require minimal nutritional support and, importantly, may be useful for identifying factors that regulate endothelial cell proliferation and tumor cell adhesion in different anatomical regions.

Inhibit key enzymes in cancer cell specific metabolic pathways to disrupt tumor cell proliferation and survival

Researchers at the University of Chicago noted that in recent years, genetically engineered herpes simplex virus studied for its efficacy against malignant tumors of the central nervous system and the liver was blocking certain types of cell death and proliferation of surviving cells.

In a first set of experiments, postdoctoral researcher and co-lead author Max - Felix Häring found that insulin increased the proliferation of mouse epithelial tumor cells in culture, as expecteIn a first set of experiments, postdoctoral researcher and co-lead author Max - Felix Häring found that insulin increased the proliferation of mouse epithelial tumor cells in culture, as expectein culture, as expected.

Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells.

Deletion of DGKζ from T cells results in prolonged TCR signal transduction downstream of DAG, resulting in enhanced activation of Ras, increased effector T cell proliferation, and amplified cytokine production, which leads to increased antitumor activity against s.c. implanted EL4 tumors or murine mesothelioma (12, 16, 17).

According to Sabatini, who is also a Howard Hughes Medical Institute investigator and professor of biology at MIT, this pathway is hyperactive in an estimated 50 - 80 % of cancers, driving tumor cell growth and proliferation.

Yet its contribution to tumor cell proliferation only increases the evidence that changes in metabolism are a cause of cancer and not just a consequence, according to Leif Ellisen, a cancer genetics researcher and oncologist who directs the MGH Translational Research Laboratory.

Miller said that other proteins anchored to the cell surface in a similar fashion are known to play roles in cell proliferation, suggesting a possible mechanism for how HYAL2 might be involved in tumor formation.

Runaway cell proliferation is driven by accelerators, or oncogenes, that are stuck on go — in collusion with broken brakes, or tumor suppressors, that can't control a tumor's pedal - to - the - metal growth.

STC2 overexpression could promote tumor cell proliferation, invasion, and metastasis in prostate cancer, ovarian cancer, or neuroblastoma.

Sclareol inhibits cell proliferation and sensitizes cells to the antiproliferative effect of bortezomib via upregulating the tumor suppressor caveolin - 1 in cervical cancer cells.

A great deal of evidence has now been amassed that stromal cell senescence plays an important role in laying the groundwork for tumor metastasis, promoting cell proliferation with inflammatory cytokines, encouraging angiogenesis, and degrading the tumor - suppressive action of an intact extracellular matrix.

Cyclin D1 has been observed in many human tumors and is likely to promote cell proliferation and differentiation by shortening the G1 / S transition.

The lab is delineating tumor dormancy in melanoma and characterizing subpopulations of cells with a major focus on slow - proliferating cells that have high proliferation potential hypothesizing that these cells are critical for dormancy and therapy resistance.

In Drosophila epithelia, the tumor suppressors Fat (Ft) and Dachsous (Ds) regulate cell proliferation, tissue morphogenesis, planar cell polarity and junction tension.

However, in the present study there is no evidence of untoward donor cell proliferation or tumor formation up to at least 130 days post-transplantation, suggesting that cell division is a regulated or balanced event.

PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K - Akt - MDM2 signaling suppression.

Dr. Mack's research has focused primarily on the use of novel antitumor agents in human estrogen receptor negative breast tumor cells, and more recently, on the use of bioflavonoids in the regulation of estrogen receptor positive (ER +) and estrogen receptor negative (ER --RRB- breast tumor cell proliferation.

New data and research approaches have created opportunities for researchers to study in detail many aspects of cancer biology, including how the normal biological programs of cell proliferation and death are altered during cancer and how the immune system responds to tumors.

These NSC - secreted antibodies assemble properly, possess tumor cell - binding affinity and specificity, and can effectively inhibit the proliferation of HER2 - overexpressing breast cancer cells in vitro.

It is also the first in an emerging class of therapies called «checkpoint blockade,» which enhance the immune system's ability to attack cancer by interfering with immunological checkpoints that slow or stop immune cell activation and proliferation in the presence of tumors or chronic viral infection.

Tumor hypoxia is often linked to decreased survival in patients with breast cancer and has been shown to induce specific molecular changes in cells including changes that confer a more malignant phenotype such as increased proliferation (3), survival (4), invasion (5), and metastasis (6).

Clonal proliferations may also be the basis for any discordance between mutations in urinary cells and in the primary tumors of the same patients.

Phytochemicals in 50 mg apple with skin per milliliter (on a wet basis) inhibit tumor cell proliferation by 42 %.

And, though they were skeptical that they would observe any difference in tumor biology in the diet - treated patients with such a short - term dietary intervention, just within those few weeks, they found significantly lower cancer proliferation rates, and significantly higher rates of cancer cell death.

The proliferation rates of the cancer in the flax - eaters were only half that of the controls, confirming the test - tube studies done on prostate cancer cells suggesting that flax can indeed slow prostate tumor growth.

(Source) Another study found lyophilized strawberries to inhibit oral tumorogenesis in hamsters (source), while a different study investigated the effects of strawberry extract on leukemia and breast cancer cells, and discovered the extract to inhibit tumor proliferation by causing cell death.

Research with animals has suggested that raspberries have have the potential to inhibit cancer cell proliferation and tumor formation in various parts of the body, including the colon.