Sentences with phrase «in tumor samples»

All of these hallmarks — reduced SIRT6, increased Lin28b and reduced let - 7 expression — were found in tumor samples from patients who died more quickly.

(F) Immunohistochemical assay of p - ERK in tumor samples of PTCL - NOS patients with or without KMT2D mutations.

In a landmark paper, Cancer Research UK funded scientists alongside an international team of researchers read all of the DNA in tumor samples from 10 men with prostate cancer.

Overall, 627 (73 %) genetic changes found in tumor samples were also found in blood samples with this approach.

Also, due to the high - priority of say, validating somatic variants in a tumor sample with 454 sequencing, we wanted something that could leverage faster aligners — parallelized BLAT for 454 and Bowtie for Illumina.

To explore this idea, Hopkins oncologists Dung Le, Luis Diaz, and others looked for mismatch repair mutations in tumor samples from patients with advanced colon cancer and other cancer types whose tumors had stopped responding to other treatments.

To see whether Lin28 might be a factor in Wilms tumor development, Daley and an international team of collaborators measured the gene's expression in tumor samples from 105 Wilms patients.

«Shifting protein networks in breast cancer may alter gene function: Changes in gene function in tumor samples correlate with patient survival.»

«And we found all three types of «gain - of - function» mutations in the estrogen receptor gene ESR1 in the tumor samples.»

As a next step, Guha, Avadhani and colleagues plan to extend this study to in vivo mouse models and will also investigate these mechanisms in tumor samples from human breast cancer patients.

Their theory was first confirmed with ovarian cancer cell lines and then the Peter / Lengyel team tested HGMA2 protein levels in tumor samples from 100 patients with ovarian cancer.

Due to either or both tumor heterogeneity and / or normal contamination (presence of DNA from normal cells in the tumor sample), coverage levels may not correspond to integer - valued ploidy.

Even lower - resolution array technologies identify recurrent LOH regions in tumor samples.

Another interesting application of massively parallel sequencing was the estimation of mutation frequencies in the tumor sample using the Roche / 454 platform.

This novel vaccine encodes the tumor antigen TERT, which is highly expressed in tumor cells, and is particularly high in tumor samples from patients with mutations in DNA damage repair pathways, such as the BRCA1 / BRCA2 pathway.

She and her colleagues sequenced genomic DNA in the tumor samples but did not find any new driver gene mutations in the metastatic samples compared to the primary tumor samples, said McDonald, who completed clinical training under Iacobuzio - Donahue at Johns Hopkins.

«In the tumor sample from a patient with high NRP - 1 expression, there was a significant improvement in the efficacy of the nanoparticle to induce tumor shrinkage,» said Nel.

In tumor samples, where we frequently encounter variants with a very small allele frequency due to contamination with normal tissue, copy number variation, and tumor heterogeneity, high coverage is essential for accurate detection of these variants with high power.