Early observations suggesting that the virus might attack cancer in part by damaging blood vessels that feed tumor growth led the SillaJen team to strike up a collaboration with McDonald, an expert
in tumor vasculature, to investigate the virus's mechanism of action in animal models.
Targeting tumor endothelial marker 8
in the tumor vasculature of colorectal carcinomas in mice.
Not exact matches
The images enable the researchers to look at blood flow
in the breasts, see how the
vasculature changes, and how the blood interacts with the
tumor.
With a view to clinical studies (tests on humans) it is important to note that the effects on the
tumor vasculature were even observed at chloroquine concentrations that had little effect on autophagy
in the cancer cells.
Unfortunately, approximately 85 percent of cancer patients are ineligible for surgery at the time of diagnosis, either because the
tumor is entwined
in critical
vasculature or the disease has progressed too far.
«The enhancing effect was not seen
in a patient
tumor sample with a low level of NRP - 1 expression on the
vasculature.
The occurrence of reoxygenation following hypoxic exposures of various degrees is inherent
in the dynamic nature of the
tumor vasculature [43, 44].
The NAVBO Meritorious Awards Committee and Council is pleased to announce the selection of Rakesh K. Jain, Ph.D., as the 2018 recipient of the Earl P. Benditt Award,
in recognition of his numerous contributions to our understanding of the unique characteristics of
tumor vasculature.
Dr. Jain's nominators note that,
in sum, his work has provided ``... unprecedented molecular, cellular, anatomical and functional insights into the vascular pathophysiology of
tumors, for proposing the seminal hypothesis that antiangiogenic therapy can «normalize» the aberrant
vasculature and microenvironment of
tumors and thereby improve both delivery and efficacy of treatment of solid
tumors.»