Sentences with phrase «in tumour cells in»

In collaboration with Dr Gabriele Bonatz from the Augusta clinics in Bochum (Brustzentrum), Hatt's team confirmed the existence of TRPV1 in tumour cells in nine different samples from patients suffering from breast cancer.

Not exact matches

When placed at the site of a cancerous tumour in a rodent and «activated» by a scope with a light source, the compounds eradicated up to 100 % of cancer cells.

Although these spots themselves are harmless, if some of the spots are bigger than a 50 cent coin, then it could be due to Neurofibromatosis (NF), which is a genetic disorder of the nervous system that causes abnormal cell growth of nerve tissues or benign tumours to form on the nerves anywhere in the body at any time.

The AR - V7 variant is formed when an androgen receptor loses the end part of the receptor, called the C - terminal end; this is deleted due to an error in RNA processing in tumour cells, leaving only the beginning part of the receptor, the N - terminal end.

We also detected circulating tumour cells, which were found in higher numbers in patients who had received more prior therapies.

«Recent data have shown that a variant of the androgen receptor called AR - V7, found in tumour cells circulating in the blood of patients with metastatic CRPC, predicted resistance to treatment with enzalutamide and abiraterone,» she will say.

«This phase III trial will be noteworthy for being the first prostate cancer trial to assess a biomarker, namely AR - V7 in circulating tumour cells, as a predictor of response at the same time as testing the efficacy of the drug,» Prof Taplin will conclude.

This suggests that the presence of AR - V7 in circulating tumour cells does not preclude response to galeterone as has been shown to be the case for abiraterone and enzalutamide.»

There were no serious side effects — and no sign of tumours, which can be a potential risk in stem cell therapies.

Gravekamp thinks the radioactive bacteria affected metastatic tumours most because cells there were still rapidly multiplying, leaving their chromosomes more open to damage than those in healthy tissues or in the original tumour.

«We are going to look for tumours, cell death and congestion in the organs that filter toxins,» she says.

A woman in the US has developed a tumour - like growth near her spine eight years after a failed stem cell treatment to cure her paralysis

In addition, Natalia Martin - Orozco at the MD Anderson Cancer Center in Houston, Texas, and her colleagues noticed Th17 cells infiltrating cancerous tumourIn addition, Natalia Martin - Orozco at the MD Anderson Cancer Center in Houston, Texas, and her colleagues noticed Th17 cells infiltrating cancerous tumourin Houston, Texas, and her colleagues noticed Th17 cells infiltrating cancerous tumours.

The suggestion is that a small number of such cells within tumours may be the precursors to the other cancer cells in those tumours.

In a revolutionary first, Cancer Research UK - funded scientists will test whether the Zika virus can destroy brain tumour cells, potentially leading to new treatments for one of the hardest to treat cancers.

«It was really surprizing to realize that oncogenic Pik3ca in basal cells induced the formation of luminal tumours, while its expression in luminal cells gave rise to heterogeneous and more aggressive tumors including basal - like tumors,» comments Alexandra Van Keymeulen, the first author of the paper.

Jeffrey Settleman of the Massachusetts General Hospital Cancer Center in Charlestown and his colleagues treated tumour cells with cancer drugs.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

These «aggregates» can comprise hundreds of thousands of cells, be up to 2 mm in diameter and be eight times more resistant to chemotherapy drugs — firstly because hypoxic conditions are created inside the aggregates and secondly because these tumour cells reduce growth and are therefore less sensitive.

«However, many patients do not respond because myeloid derived suppressor cells (MDSCs), a type of inhibitory cell, are present in the tumour microenvironment.»

These results were facilitated by the permanent cultivation of circulating tumour cells of patients with advanced SCLC in Vienna.

Martin - Orozco believes that Th17 cells recognise tumours and, in response, release chemicals that attract immune cells called dendritic cells to the tumour.

«We would hope to create little protein factories in the tumour cell that are only switched on when the cells are hypoxic,» says Kingsman.

Resistant tumour cells tend to develop in oxygen - deprived parts of the tumour.

The main reason why people die of cancer is that the cancer cells spread to form daughter tumours, or metastases, in vital organs, such as the lungs and liver.

These were released into tumour cells that had been taken from glioblastoma patients and grown in the lab.

The team found that exposing samples of human glioblastoma tumours grown in a dish to the Zika virus destroyed the cancer stem cells.

Cancer stem - like cells are thought to be the root cause of chemotherapy resistance, leading to treatment failure in patients with advanced disease and the triggers of tumour recurrence and metastasis (regrowth).

The importance of exosomes in the tumour microenvironment has been demonstrated within the field in recent years, as it has been shown that tumour development is halted if the production of exosomes inside the cancer cell is stopped.

«With this breakthrough it is possible to generate cell models with the same alterations as observed in tumour cells from patients, which will allow us to study their role in tumour development,» says CNIO researcher Sandra Rodríguez - Perales.

Devil Facial Tumour Disease (DFTD) is a rare contagious facial tumour, which emerged from a neural (Schwann) cell in a single Tasmanian devil more than 18 yearTumour Disease (DFTD) is a rare contagious facial tumour, which emerged from a neural (Schwann) cell in a single Tasmanian devil more than 18 yeartumour, which emerged from a neural (Schwann) cell in a single Tasmanian devil more than 18 years ago.

High levels of the protein were also found in cultures of metastatic cells from tumours of the colon, breast, head and neck.

Testicular germ cell tumours are the most common solid malignant tumour in young Caucasian men.

Rodríguez - Perales, Torres and Ramírez have shown that by transferring the RGEN components into primary human cells, regions of the exchanged chromosomes in some tumours can be marked, thus generating cuts in those chromosomes.

Around 15 per cent of women with breast cancer have this form of the disease, in which tumour cells lack the three receptors that most drugs target.

The researchers hope that ultimately human trials will prove the efficacy of the OH14 compound in sensitising tumour cells and cancer stem cells to existing drug - based therapies thus disabling tumours from seeding new growth after treatment.

A COMPOUND that slows the proliferation of triple - negative breast cancer cells in lab tests could lead to the first drugs to target this aggressive type of tumour.

One approach would be to identify immune cells in a tumour, grow them in a lab, and then infuse them back into the patient — a technique called adoptive cell transfer.

«In most cases we think the body's growth control mechanisms eventually stop the cells from proliferating further, but in occasional cases where additional mutations occur in the clump of cells, a tumour will eventually develop,» says Andrew Wilkie also of the University of Oxford, who supervised the worIn most cases we think the body's growth control mechanisms eventually stop the cells from proliferating further, but in occasional cases where additional mutations occur in the clump of cells, a tumour will eventually develop,» says Andrew Wilkie also of the University of Oxford, who supervised the worin occasional cases where additional mutations occur in the clump of cells, a tumour will eventually develop,» says Andrew Wilkie also of the University of Oxford, who supervised the worin the clump of cells, a tumour will eventually develop,» says Andrew Wilkie also of the University of Oxford, who supervised the work.

Anne Goriely of the University of Oxford and her colleagues took tumour cells from men with benign testicular tumours and looked for specific mutations in the FGFR3 and HRAS genes.

Mutations that occur in the first malignant cells, those in the trunk of this evolutionary tree, will end up in all the tumour cells; mutations that arise later will be found only in the tree's branches.

How do the genetically diverse cells in a tumour interact, for example, and what is the role of the cellular environment that they inhabit?

A woman in the US has developed a tumour - like growth eight years after a stem cell treatment to cure her paralysis failed.

And in 2010, a 46 - year - old woman developed multiple tumours in her kidney after having her own bone marrow stem cells injected at a private clinic in an attempt to treat her kidney failure.

A more highly publicised case was in 2009, when an Israeli teenager developed brain and spinal tumours after receiving several implants of fetal stem cells in Moscow to treat a rare degenerative condition.

Now, the researchers have discovered an alternative in a mouse model: in the case of breast tumours with a specific defect in DNA repair, the animals can be cured using already established, cheap chemotherapy drugs, if enough DNA damage can be inflicted on the resting tumour cells.

Germ cells can develop into tumours — both benign and malignant — particularly in the testes or ovaries, where the cells are normally found.

Batimastat does not work this way: instead, it is designed to keep cancers in check by preventing malignant cells breaking away and forming secondary tumours elsewhere in the body.

The ideal tool for diagnosis would be a non-invasive blood test; however, currently available tests only identify around three in five malignant germ cell tumours, potentially delaying diagnosis and the ability to prioritise patients for surgery.

This would then use the protein to recognise a foreign or tumour cell, attach to it and release the toxin in a high local concentration, which would cause the death of the tumour cell.