Sentences with phrase «in tumour microenvironments»

An anticancer agent, pyrvinium pamoate inhibits the NADH - fumarate reductase system - a unique mitochondrial energy metabolism in tumour microenvironments.

«However, many patients do not respond because myeloid derived suppressor cells (MDSCs), a type of inhibitory cell, are present in the tumour microenvironment.»

The importance of exosomes in the tumour microenvironment has been demonstrated within the field in recent years, as it has been shown that tumour development is halted if the production of exosomes inside the cancer cell is stopped.

For example, low grade inflammation in the tumour microenvironment can attract detrimental regulatory cells and neutrophils which can inhibit tumour immunity and promote tumorigenic factors.14

We take a multidisciplinary approach to explore the mechanisms and evolution of stromal - mediated immune dysfunction in the tumour microenvironment and uncouple the immunoregulatory systems governing their suppressive function.

Not exact matches

Zebrafish provide a similar tumour microenvironment to humans, meaning fewer tests need to be carried out in mice and any future experiments in mice will have been optimised to have minimal toxicity.

One of the data sets came from researchers studying a mouse tumour model, to discover how the microenvironment adapts and responds to a tumour over time, both locally and in the draining lymph node.

Mimicking the tumour microenvironment (TME): Angiogenesis in tumour progression.

We have developed pre-clinical models to identify genes, both in the tumour cells and in the microenvironment that regulate the spread of cancer to specific organs such as the liver, lungs and brain.

This multi-stage process requires tumour cells to survive in the circulation, extravasate at distant sites, then proliferate; it involves contributions from both the tumour cell and tumour microenvironment («host», which includes stromal cells and the immune system).

From the tolerogenic tumour microenvironment, to the immune cells» intrinsic regulatory mechanisms, many hurdles stand in the way.

· Cancer Growth and Spread — Healing Angiogenesis and Metastasis, discussing blood vessel development and growth factors, dysregulation including hypoxia and other blood supply stress responses in cancer and other diseases and how cancer cells travel and invade — metastasis via the complex tumour microenvironment — TME — comprised of immune cells, cytokines, growth factors, reactive oxygen species (ROS) and cancer - associated fibroblast (CAF);