Sentences with phrase «in tumour progression»
Mimicking the tumour microenvironment (TME): Angiogenesis in tumour progression.
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«Naked mole rats have an additional barrier in the way of tumour progression,» says Seluanov, who presented the results at the Strategies for Engineered Negligible Senescence meeting in Cambridge, UK, last week.
Although these results are an important step forward in understanding the mechanisms of tumour progression, more research is needed before this treatment can be applied to clinical practice.
The addition of necitumumab to gemcitabine and cisplatin chemotherapy improved overall survival and progression free survival by 21 % and 16 %, respectively, as compared to chemotherapy alone in patients whose tumours expressed the EGFR protein.
«The new knowledge we have gained facilitates the design of prophylactic and therapeutic measures for delaying tumour progression and extending cancer - free periods in RDEB,» says Venugopal Rao Mittapalli, the first author of the study.
For patients with cervical cancer that has recurred after treatment or has spread elsewhere in the body, adding the experimental drug cediranib to standard chemotherapy improves tumour shrinkage and adds a modest improvement in progression - free survival, researchers report at the ESMO 2014 Congress in Madrid.
«Similarly 71 drugs approved by the FDA from 2002 to 2014 for solid tumours have resulted in median gains in progression - free and overall survival of only 2.5 and 2.1 months, respectively,» he says adding, «Also, only 42 per cent met the American Society of Clinical Oncology Cancer Research Committee's criteria for meaningful results for patients.»
Most of the studies have focused mainly on tumour cells, whilst the cells that form the stroma are the great unknown, in spite of different research groups proving that some components of stroma promote the tumour progression.
However, a tumour can trick neutrophils to become activated even in the absence of an infection, and as a consequence they contribute to disease progression and tissue damage.
By conducting an RNA - sequencing experiment of 103 matched tumour and normal colon mucosa samples from Danish CRC patients, 90 of which were germline - genotyped, researchers from the collaborative European project SYSCOL show that both inherited and acquired mutations in non-coding regions of the genome also contribute to cancer development and progression (Linda Koch, Nature Reviews Genetics).
We then monitored mammary tumour incidence and progression in this mouse line on Slc6a14 + / + and Slc6a14 − / − genetic backgrounds.
Senescent cells may promote tumour progression through the activation of a senescence - associated secretory phenotype (SASP), whether these cells are capable of initiating tumourigenesis in vivo is not known.
Because the tumour is located in an area of the brain which makes surgery risky, Alix is on a watchful waiting program, with brain scans every six months to monitor for progression.