Sentences with phrase «in tumour tissue»

Analysis of transcriptomes in tumour tissues from wild - type mice and Slc6a14 - null mice indicated no compensatory changes in the expression of any other amino acid transporter mRNA.

Not exact matches

Although these spots themselves are harmless, if some of the spots are bigger than a 50 cent coin, then it could be due to Neurofibromatosis (NF), which is a genetic disorder of the nervous system that causes abnormal cell growth of nerve tissues or benign tumours to form on the nerves anywhere in the body at any time.

Liposomes, < 200 nm phospholipid vesicles, are longer retained in blood circulation and accumulate at pathological sites (tumours or inflamed tissues), leading to higher efficacy and lower systemic toxicity compared to the free drugs they encapsulate.

In previous work in mice, Claudia Gravekamp of the Albert Einstein College of Medicine in New York had shown that weakened listeria bacteria colonise tumour tissue but not healthy tissuIn previous work in mice, Claudia Gravekamp of the Albert Einstein College of Medicine in New York had shown that weakened listeria bacteria colonise tumour tissue but not healthy tissuin mice, Claudia Gravekamp of the Albert Einstein College of Medicine in New York had shown that weakened listeria bacteria colonise tumour tissue but not healthy tissuin New York had shown that weakened listeria bacteria colonise tumour tissue but not healthy tissue.

Gravekamp thinks the radioactive bacteria affected metastatic tumours most because cells there were still rapidly multiplying, leaving their chromosomes more open to damage than those in healthy tissues or in the original tumour.

The magnets can sculpt balls into shapes that resemble tumours and tissues growing in the body.

«Some tissues showed faster methylation than others, for example in the liver, colon and spleen, and that's exactly where we saw the tumours grow,» says Shen.

Now the mechanism has been revealed, opening the way to using similar molecules in cancer treatments, to protect healthy tissue while tumours are destroyed by freezing.

Many people have experienced this among their family, friends or acquaintances: at first, the chemotherapy is extremely effective in cancer patients, although the tumour has metastasised, i.e. it has settled in remote tissue.

Acidic conditions are found in inflamed tissue and in growing tumours that are beginning to spread to other sites in the body.

This database contains spectra of already known tissues and tumours, and has been established in the PURE consortium as a collaboration between pathologists, biophysicists and bioinformaticians.

The team has now also tested the bacteria on a woman with tumours in her liver, lungs and soft tissue that didn't respond to standard treatment.

Ribeiro's team is now investigating the molecular composition of the fat around the kidneys, particularly tissue in close contact with tumours.

This is in part due to the difficulty in acquiring samples of tumours that have spread to other tissues.

Growing them in animals makes for more lifelike tumours, and can produce large quantities of tissue for study.

Research fields are diverse, including basic research on cell proliferation, analysis of tumour cells and tissues to detect gene mutations, and identification of potential therapeutic targets in cancer.

This suggests that molecular mechanisms that have evolved to promote tissue repair are closely related to those involved in tumour formation, which could help us understand cancers.»

The specialist in Uro - oncology added that if NTU's technology proves to be viable, clinicians might be able to localise and concentrate the anticancer drugs around a tumour, and introduce the drugs deep into tumour tissues in just a few seconds using a clinical ultrasound system.

In the mice, the neuron - like cells did not grow as quickly as the original cancer cells, and analyses of the tumour tissue from patients show that those with a high level of the estrogen receptor have a better survival rate that those with a low.

This has always been a worry with tissues produced from embryonic stem cells, as these have the capability to form tumours if any are left in their original state in the transplanted tissue.

The researchers studied tumour tissue from patients, cultivated human tumour cells and tumours in mouse models for neuroblastoma.

However, a tumour can trick neutrophils to become activated even in the absence of an infection, and as a consequence they contribute to disease progression and tissue damage.

This results in edema in the tissues, which in turn makes it more difficult for drugs to reach into the tumour during cancer therapy.

By comparing the epigenetic profiles of gastric tumours to normal tissues from the same patient, we were able to identify those promoters specifically altered in GC tissues.»

Scientists tested for microRNA 135b in 485 patients with bowel cancer and found that levels were at least four times as high in tumours as in healthy tissue, and that patients with the highest levels survived the least long.

The trick is to pick anaerobic bacteria that thrive in the oxygen - poor interior of fast - growing tumours, but die as they reach oxygen - rich healthy tissue.

In the case of cancer, ineffective cell adhesion allows tumour cells to detach and invade other tissues, thereby spreading cancer throughout the body.

Resected tumours were embedded in Tissue - Tek OCT compound, frozen on dry ice and cut into 8 μm sections.

We see extensive variability in genomes among tumours of different tissue types, among different patients within a tissue type and among subclones within a given patient's cancer.

Meguro, Japan (Scicasts)- Tumour detection using targeted fluorescent imaging probes is a promising technology that takes advantage of specific molecular events occurring in cancer tissues.

Therefore, a protein containing the ODD would be intact in hypoxic tumours, but destroyed in normoxic tissues.

In order to confirm the virus's involvement in the cancer, the research team compared tumour tissues with normal tissueIn order to confirm the virus's involvement in the cancer, the research team compared tumour tissues with normal tissuein the cancer, the research team compared tumour tissues with normal tissues.

The technique is insensitive to the level of mutated cancer cells in the sample, and the information about mutations can be linked directly to the way the tumour cells are growing in the tissue sample.

However, these factors can produce harmful effects in the body, such as unwanted tissue growth and tumours.

He added that, aside from the hope of creating replacement tissues and organs for patients, the work could help scientists understand how to tackle unwanted blood vessel growth, such as that found in tumours.

ab16056 staining COX IV in breast tumour tissue sections by Immunohistochemistry (IHC - P - paraformaldehyde - fixed, paraffin - embedded sections).

In the new study, scientists at King's College London, led by Dr Anita Grigoriadis from the Breast Cancer Now Research Unit at King's College London, studied lymph node tissue and primary tumour samples from 309 breast cancer patients, who were treated between 1984 and 2002 at Guy's Hospital London.

«It's fascinating that it's so complicated», says Gerard, «there is a code we don't yet understand that differs from tissue to tissue — the number of chemokines and cytokines is distinct in each tissue type and the types of cells that enter and exit the tumour also differ».

Inclusion Criteria: • Availability of tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion criteria

They also form a platform for discovering fibroblast lineages in other tissues and for examining fibroblast changes in ageing and disease (i.e, tumour formation).

(A) Demonstration of Slc6a14 mRNA up - regulation in PyMT - driven mammary tumours in mice; N, mammary tissue from wild - type mice; T, mammary tumour tissue from PyMT - Tg mice.

They are seeking a Scientific Officer 2 to jointly work within our Tissue Biomarkers Team and Tumour Immunology and Inflammation Monitoring Laboratory Team (TIIML) to assist in the development and implementation of tissue biomarkers to monitor immune status and respTissue Biomarkers Team and Tumour Immunology and Inflammation Monitoring Laboratory Team (TIIML) to assist in the development and implementation of tissue biomarkers to monitor immune status and resptissue biomarkers to monitor immune status and responses.

While the cancer in dogs shares characteristics with humans, there are differences in the likelihood of the cancer metastasizing and the tissue of the prostate.ANCHOR However, by studying the prostate gland in dogs, Charles Huggins discovered that the growth of tumours was dependant on the natural hormones of the body.

Some receptors display a broad pattern of expression across tumour types, while others were expressed in cell lines from a particular tissue.

«[H] igh LDL receptor content in human breast cancer tissue seems to indicate a poor prognosis, suggest [ing] that breast tumours rich in LDL receptors may grow rapidly» in the body.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseaseIn addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein the treatment of convulsion diseases.

Acquired abnormalities include damage to the tear duct system due to factors such as infection, injury to the eyelid, trauma to the area around the eyes affecting the bones and soft tissues, irritations due to facial hair around the eyes, infections of the conjunctiva, cornea or tissues inside the eye, increased pressure in the eye, as well as tumours in or around the eyes.