Sentences with phrase «in vaccine strategies»

Ebola expert Steven Bradfute shares the latest trends in vaccine strategies and research investigating mechanisms of Ebola...

Bach2, an important gene for inducing memory B cells, may become an important target in vaccine strategies.

Not exact matches

But there was widespread agreement among the working group's on - the - ground experts — including Panjabi; Ngozi Okonjo - Iweala, the former Nigerian finance minister who now chairs Gavi, the Vaccine Alliance; Helle Thorning - Schmidt, CEO of Save the Children International; and Andrew Youn of the One Acre Fund — that only a more comprehensive health strategy would make any real dent in childhood mortality.

With all of the interest in developing new therapeutics, new vaccines, and strategies for fighting bioterrorism, immunology poses many serious questions for scientists.

To date, only six patients (including Menezes) for whom the vaccination strategy failed have survived, the first was 6 year - old Matthew Winkler from Ohio, who was bitten by a rabid bat in 1970 and developed symptoms after receiving a full course of the vaccine (prior versions of the rabies vaccine were not as effective as current formulations).

But, Anderson and Ping noted, «if we can find that these differences in the virus populations are important in transmission... then we can begin to apply this knowledge to vaccine and prevention strategies.»

These study results highlighting this promising strategy are published in npj Vaccines.

«We use a prime - boost strategy, meaning that we immunize with two vehicles that deliver the vaccine in different ways,» Nabel says.

The findings shed light on the effectiveness of whooping cough vaccines in the U.S. — a subject of intense scientific debate — and may help guide future vaccination campaigns and public health strategies.

«These results imply that, of the options currently available utilizing adjuvants included in the national stockpile, based on the immune response data, AS03 should be considered a first - line adjuvant for strategies incorporating an inactivated H7N9 vaccine in adults,» the authors write.

Because there are no vaccines or cures for these viruses there is an increased urgency of those in the public health sector to identify alternative strategies to manage the disease, of which an early warning system is included.

Kristien Van Reeth, of Belgium's Ghent University, and collaborators are comparing different vaccines and vaccination strategies in swine, which are used as a model for humans.

The authors note that manufacturing strategies may also play a significant role in reduced vaccine effectiveness.

This could lead to new HIV vaccine strategies that are able to stimulate the rare precursors of these protective antibodies,» says Professor Lynn Morris, from the National Health Laboratory Service in the Wits School of Pathology who leads the research team at the NICD.

The researchers contend that this vaccine strategy has «tremendous potential» in mass vaccination campaigns as it's so much simpler to deliver than injections.

«Our work so far suggests that this new vaccine strategy induces a level of virus neutralization about 25 times greater, after a single dose, than one sees in standard vaccines,» Weissman said.

«We observed rapid and durable protective immunity without adverse events, and so we think this candidate vaccine represents a promising strategy for the global fight against Zika virus,» said senior author Drew Weissman, MD, PhD, a professor of Infectious Disease at Penn. «We hope to start clinical trials in 12 to 18 months.»

Yale Cancer Center researchers have developed a vaccine strategy that reduces the risk of flu infections in cancer patients at highest risk for influenza.

The vaccine was targeted especially toward the virus strain circulating in Thailand, and it may not show the same effectiveness where the virus is different, such as Africa or the U.S. And even the 31.2 percent fewer cases that it resulted in is hardly an ideal preventative strategy.

If the vaccine also proves safe and effective in subsequent tests in humans, it might be possible to mount a containment strategy similar to that used in the past against smallpox.

Nevertheless, he believes that the new research may eventually lead to strategies for preventing MS. «In cases where multiple sclerosis runs in families, one could identify children who have inherited high - risk genes, and give them preventive vaccines,» he sayIn cases where multiple sclerosis runs in families, one could identify children who have inherited high - risk genes, and give them preventive vaccines,» he sayin families, one could identify children who have inherited high - risk genes, and give them preventive vaccines,» he says.

«In pursuit of a universal flu vaccine: Study shows pros, cons for major strategy to create broadly protective shot.»

This is no easy task, and a study out in the journal Scientific Reports suggests that one of the most promising strategies — creating a vaccine that targets the «stalk» of a protein that covers the flu virus — is a strong one, but isn't completely bulletproof.

For this survey of global health, Science has joined forces with Science Translational Medicine, which examines vaccine development, strategies against emerging infections, progress in point - of - care diagnostics, and ways to promote mental health and neonatal health.

Mothe and her colleagues tried that strategy with an HIV vaccine made by Tomáš Hanke of the University of Oxford in the United Kingdom.

Identifying those two molecular targets could help in the design of better vaccine strategies and tumor immunotherapies.»

«We found that the NFkB - Pim1 - Eomes axis, an important molecular mechanism that operates in memory T cells, could be enhanced with molecular or genetic strategies to help current vaccines or tumor therapies be more effective.

Such campaigns are the backbone of the global push to eradicate polio, but this month the World Health Organization (WHO) in Geneva, Switzerland, proposed a shift in vaccination strategy from oral vaccines to injected ones that may have to be administered in clinics.

«Better understanding of these mechanisms is important because increasing the quantity and quality of memory CD8 + T cells is a key goal in developing more effective vaccines and immunotherapeutic strategies,» said Tan.

These observations helped scientists characterize the biology of HPV infection at each anatomic site and aid in the development of HPV prevention strategies, including the vaccines Cervarix ® and Gardasil ®.

Furthermore, the researchers show that their strategy for immunization against a self - molecule is highly efficient and can be achieved with an adjuvant (immunostimulatory compound included in vaccines) that is acceptable for use in the clinic.

«The optimal strategy for protecting people and animals against this deadly disease would be through vaccination, but there are no FDA - licensed plague vaccines available in the U.S.,» said Ashok Chopra, UTMB professor of microbiology and immunology.

Still, says Weiner, there are ways to enhance efficacy, for instance by trying more or different genes or by using a so - called prime - boost strategy, in which the DNA vaccine is followed by a shot with the protein subunits themselves.

A study published 2 years ago in Science suggested the strategy might work: It showed that a neoantigen vaccine stimulated immune responses in three advanced melanoma patients who had already received a cancer drug.

Although an autologous tier 2 NAb response is not sufficient for vaccine protection against HIV - 1, it may be a necessary step in various strategies intended to induce bNAbs.

«In lieu of a practical means of delivering [canine distemper virus] vaccines to wild tigers, the most viable strategy to ensure their conservation is the maintenance of large connected populations within protected areas that buffer the effects of local declines,» Gilbert and colleagues write.

Halstead says it may be time to reconsider the four - vaccines - in - one strategy.

Now researchers have used a new strategy to develop a vaccine that protects mice from multiple variants of the Strep B bug, which kills around 100 newborns in the United States each year.

«This vaccine is a successful advancement in developing control strategies for Zika virus by creating widespread immunity in susceptible populations,» said Stephen Higgs, director of the Biosecurity Research Institute.

The current epizootic in the Far East caused by avian influenza virus A (H5N1) has led to real concern about the possibility of a new pandemic of influenza.12 Technological innovation, such as the use of new vaccines delivered by the intradermal route, offers great promise to change and improve on current immunization strategies.

We aim to develop a globally - effective HIV vaccine which, in combination with other proven prevention strategies, would enable us not only to protect our Warfighters from HIV, but would be critical in the control of the global pandemic.

Heidi's unrelenting style can be seen across all areas of Hookipa, including a major role in the clinical strategy, scientific advice and clinical trial application for the Vaxwave cytomegalovirus vaccine candidate HB - 101.

She brings more than 10 years of experience in the field of regulatory affairs and has been involved in global licensing strategies of various developmental vaccines in her former roles.

Randomized, Double - Blind Evaluation of Late Boost Strategies for HIV - Uninfected Vaccine Recipients in the RV144 HIV Vaccine Efficacy Trial.

Five years ago, he enrolled in a study at the UNC School of Medicine, which was part of Dr. David Margolis» «kick and kill» strategy for eradicating HIV by flushing it out of hiding with a drug called Vorinostat and killing it with either a vaccine

In the new issue of IAVI Report we wrote about how researchers at the AIDS Vaccine 2010 conference in Atlanta discussed the limited window of opportunity for conducting clinical trials to test partially effective HIV prevention strategies, including HIV vaccine candidates and oral or topical antiretroviral pre-exposure prophylaxis (PrEP), in combinatioIn the new issue of IAVI Report we wrote about how researchers at the AIDS Vaccine 2010 conference in Atlanta discussed the limited window of opportunity for conducting clinical trials to test partially effective HIV prevention strategies, including HIV vaccine candidates and oral or topical antiretroviral pre-exposure prophylaxis (PrEP), in combiVaccine 2010 conference in Atlanta discussed the limited window of opportunity for conducting clinical trials to test partially effective HIV prevention strategies, including HIV vaccine candidates and oral or topical antiretroviral pre-exposure prophylaxis (PrEP), in combinatioin Atlanta discussed the limited window of opportunity for conducting clinical trials to test partially effective HIV prevention strategies, including HIV vaccine candidates and oral or topical antiretroviral pre-exposure prophylaxis (PrEP), in combivaccine candidates and oral or topical antiretroviral pre-exposure prophylaxis (PrEP), in combinatioin combination.

The finding points to a possible new strategy in the search for an effective AIDS vaccine.

This next stage in HIV vaccine research requires a strengthened global strategy that

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

She is completing her postdoctoral training at IDRI and is excited to use her background in adaptive immunity to help optimize vaccine strategies for pathogens like Mycobacterium tuberculosis.