Sentences with phrase «in vaccinia»

Temperature - sensitive mutants with lesions in the vaccinia virus F10 kinase undergo arrest at the earliest stage of virion morphogenesis.

Elucidating the essential role of the A14 phosphoprotein in vaccinia virus morphogenesis: construction and characterization of a Tetracycline - inducible recombinant.

Not exact matches

Bavarian Nordic, a German - Danish company, produces a weakened vaccinia strain called Modified Vaccinia Ankara (MVA) that doesn't replicate in humans.

Lederman, who says he's «obsessed» with Jenner and has been working on a biography of the scientist for 20 years, is convinced that Jenner's original vaccine, now named vaccinia, was derived from a virus circulating in horses, not cows, as folklore has it.

In a conversation about one of Evan's earlier vaccinia papers, Lederman told Evans that he'd love to know whether horsepox still works as a vaccine, but that he had had trouble getting hold of the virus.

Protein chemist Michael Way, cell biologist Sally Cudmore, and their colleagues at the European Molecular Biology Laboratory in Heidelberg and at the Pasteur Institute in Paris have found that vaccinia — a virus used in smallpox vaccines — surfs through cells on piles of actin, one of the basic structural proteins in the cellular skeleton.

In vivo, primary and secondary cytotoxic T cell responses against vaccinia and lymphocytic choriomeningitis virus were within normal ranges.

However, the classic smallpox vaccine, a weakened poxvirus called vaccinia, can cause serious side effects and even death in people with compromised immune systems, eczema, or atopic dermatitis.

Similarly, the entry for vaccinia, and even an essay on virology (one of 124 «windows» reviews by luminaries in their fields), mention smallpox without saying that it has been eradicated — one of the greatest achievements of medical science.

Both assays (for translation enhancement and internal ribosomal initiation) were validated under cell - free conditions and in human cells, using a vaccinia virus vector.

When researchers infected these ERV - depleted cells with the vaccinia virus (which may be related to smallpox), they had a much weaker innate immune response than unedited normal cells, the team reports online today in Science.

The standard smallpox vaccine, a virus called vaccinia, is amazingly effective, which explains how the disease was eradicated in the late 1970s.

PANVAC - V, which uses the same virus as the smallpox vaccine, is a live but weakened vaccinia vaccine (meaning the virus can still multiply) that is given in the arm.

Using a light microscope, researchers at the Swiss Federal Institute of Technology in Zürich watched fluorescently tagged vaccinia virus — a more benign cousin of smallpox virus — migrate toward target cells.

When the vaccinia virus was delivered in CIK cells, it was evenly distributed throughout the tumor (left).

Thanks to its resemblance to the smallpox virus, researchers were able to use vaccinia as a vaccine for the disease, eventually leading to its eradication in the late 1970s.

«The novelty here, with vaccinia, is that it's not just preventing the virus superinfecting, but physically it's repelling the virus away,» says Smith, whose team reports its findings today in Science.

(D) The average number of somatic hypermutations in the pandemic H1N1 patient plasmablast variable region genes compared with primary IgG plasmablast responses to vaccinia (small pox) or the anthrax vaccine, or after at least 4 boosters with the anthrax vaccine.

Jäger E, Karbach J, Gnjatic S, Neumann A, Bender A, Valmori D, Ayyoub M, Ritter E, Ritter G, Jäger D, Panicali D, Hoffman E, Pan L, Oettgen H, Old LJ, Knuth A. Recombinant vaccinia / fowlpox NY - ESO - 1 vaccines induce both humoral and cellular NY - ESO -1-specific immune responses in cancer patients.

[3] Odunsi K, Matsuzaki J, Karbach J, Neumann A, Mhawech - Fauceglia P, Miller A, Beck A, Morrison CD, Ritter G, Godoy H, Lele S, duPont N, Edwards R, Shrikant P, Old LJ, Gnjatic S, Jäger E. Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY - ESO - 1 antigen in ovarian cancer and melanoma patients.

On March 3, 2007, a two - year - old boy suffering from severe eczema and an unusual, widespread rash was transferred from St. Catherine's Hospital, in East Chicago, IN, to the University of Chicago's Comer Children's Hospital where he was diagnosed with eczema vaccinatum — a rare, severe, adverse reaction to the vaccinia viruin East Chicago, IN, to the University of Chicago's Comer Children's Hospital where he was diagnosed with eczema vaccinatum — a rare, severe, adverse reaction to the vaccinia viruIN, to the University of Chicago's Comer Children's Hospital where he was diagnosed with eczema vaccinatum — a rare, severe, adverse reaction to the vaccinia virus.

Differences and similarities in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified vaccinia virus Ankara and vaccinia virus.

Raised in mice primed with a SIVmac251 gp160 vaccinia recombinant (vAbT253), and boosted with glutaraldehyde - fixed SIVmac11 / 88 from C8166 cells.

The Pexa - Vec virus was originally developed by Michael Mastrangelo, MD, and Edmund Lattime, PhD, of Thomas Jefferson University in Philadelphia, who engineered the harmless vaccinia virus to infect only cancer cells and other rapidly dividing cells, as well as to stimulate immune activity, in hopes of boosting the immune response to tumors.

Prime - boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adult.

In another report, vaccinia was used as a vector vaccine for immunizing Balb / c mice with each of the SARS - CoV structural proteins (N, S, membrane, and envelope) and then challenged with SARS - CoV [21].

While at UConn, he researched improvements to the system for generating recombinant vaccinia viruses in the laboratory of Dr. Paulo Verardi.

Odunsi K, Matsuzaki J, Karbach J, Neumann A, Mhawech - Fauceglia P, Miller A, Beck A, Morrison CD, Ritter G, Godoy H, Lele S, Dupont N, Edwards R, Shrikant P, Old LJ, Gnjatic S, Jager E. (2012) Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY - ESO - 1 antigen in ovarian cancer and melanoma patients.

Agricola J, Munseri PJ, Nilsson C, Bakari M, Aboud S, Lyamuya EF, Tecleab T, Liakina V, Scarlatti G, Robb, ML, Earl PL, Moss B, Wahren B, Mhalu F, Ferrari G, Sandstrom E, Biberfeld G. Three - year durability of immune responses induced by HIV - DNA and HIV - modified vaccinia virus Ankara and effect of a late HIV - MVA boost in Tanzanian volunteers.